R
Robert Yu
Researcher at University of Texas MD Anderson Cancer Center
Publications - 61
Citations - 3245
Robert Yu is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 16, co-authored 51 publications receiving 2835 citations. Previous affiliations of Robert Yu include University of Texas Health Science Center at Houston & Rice University.
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Journal ArticleDOI
Genome-wide association study identifies five susceptibility loci for glioma
Sanjay Shete,Fay J. Hosking,Lindsay B. Robertson,Sara E. Dobbins,Marc Sanson,Beatrice Malmer,Matthias Simon,Yannick Marie,Blandine Boisselier,Jean Yves Delattre,Khê Hoang-Xuan,Soufiane El Hallani,Ahmed Idbaih,Diana Zelenika,Ulrika Andersson,Roger Henriksson,A. Tommy Bergenheim,Maria Feychting,Stefan Lönn,Anders Ahlbom,Johannes Schramm,Michael Linnebank,Kari Hemminki,Rajesh Kumar,S. J. Hepworth,Amy Price,Georgina Armstrong,Yanhong Liu,Xiangjun Gu,Robert Yu,Ching C. Lau,Minouk J. Schoemaker,Kenneth Muir,Anthony J. Swerdlow,Mark Lathrop,Melissa L. Bondy,Richard S. Houlston +36 more
TL;DR: Meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs shows that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor.
Journal ArticleDOI
Mutations in smooth muscle α-actin ( ACTA2 ) lead to thoracic aortic aneurysms and dissections
Dongchuan Guo,Hariyadarshi Pannu,Van Tran-Fadulu,Christina L. Papke,Robert Yu,Nili Avidan,Scott Bourgeois,Anthony L. Estrera,Hazim J. Safi,Elizabeth Sparks,David J. Amor,Lesley C. Adès,Vivienne McConnell,Colin E. Willoughby,Dianne N. Abuelo,Marcia C. Willing,Richard A. Lewis,Dong H. Kim,Steve Scherer,Poyee P. Tung,Chul Ahn,L. Maximilian Buja,Chander Raman,Sanjay Shete,Dianna M. Milewicz +24 more
TL;DR: It is shown that missense mutations in ACTA2 are responsible for 14% of inherited ascending thoracic aortic aneurysms and dissections (TAAD), and the importance of SMC contraction in maintaining the structural integrity of the ascending aorta is indicated.
Journal ArticleDOI
Mutations in Smooth Muscle Alpha-Actin (ACTA2) Cause Coronary Artery Disease, Stroke, and Moyamoya Disease, Along with Thoracic Aortic Disease
Dongchuan Guo,Christina L. Papke,Van Tran-Fadulu,Ellen S. Regalado,Nili Avidan,Ralph J. Johnson,Dong H. Kim,Hariyadarshi Pannu,Marcia C. Willing,Elizabeth Sparks,Reed E. Pyeritz,Michael N. Singh,Ronald L. Dalman,James C. Grotta,Ali J. Marian,Ali J. Marian,Eric Boerwinkle,Eric Boerwinkle,Lorraine Frazier,Scott A. LeMaire,Scott A. LeMaire,Joseph S. Coselli,Joseph S. Coselli,Anthony L. Estrera,Hazim J. Safi,Sudha Veeraraghavan,Donna M. Muzny,David A. Wheeler,James T. Willerson,Robert Yu,Sanjay Shete,Steven E. Scherer,Chander Raman,L. Maximilian Buja,Dianna M. Milewicz,Dianna M. Milewicz +35 more
TL;DR: The results indicate that heterozygous ACTA2 mutations predispose patients to a variety of diffuse and diverse vascular diseases, including TAAD, premature CAD, ischemic strokes, and MMD and have direct implications for clinical management and research on familial vascular diseases.
Journal ArticleDOI
Corrigendum: Mutations in smooth muscle α-actin (ACTA2) lead to thoracic aortic aneurysms and dissections (Nature Genetics (2007) 39, (1488-1493))
Dongchuan Guo,Hariyadarshi Pannu,Van Tran-Fadulu,Christina L. Papke,Robert Yu,Nili Avidan,Scott Bourgeois,Anthony L. Estrera,Hazim J. Safi,Elizabeth Sparks,David J. Amor,Lesley C. Adès,Vivienne McConnell,Colin E. Willoughby,Dianne N. Abuelo,Marcia C. Willing,Richard A. Lewis,Dong H. Kim,Stephen W. Scherer,Poyee P. Tung,Chul Ahn,L. Maximilian Buja,Chander Raman,Sanjay Shete,Dianna M. Milewicz +24 more
TL;DR: It is shown that missense mutations in ACTA2 are responsible for 14% of inherited ascending thoracic aortic aneurysms and dissections (TAAD), and the importance of SMC contraction in maintaining the structural integrity of the ascending aorta is indicated.
Journal ArticleDOI
Chromosome 7p11.2 (EGFR) variation influences glioma risk
Marc Sanson,Fay J. Hosking,Sanjay Shete,Diana Zelenika,Sara E. Dobbins,Yussanne Ma,Victor Enciso-Mora,Ahmed Idbaih,Jean Yves Delattre,Khê Hoang-Xuan,Yannick Marie,Blandine Boisselier,Catherine Carpentier,X Wang,Anna Luisa Di Stefano,Marianne Labussière,Konstantinos Gousias,Johannes Schramm,Anne Boland,Doris Lechner,Ivo Gut,Georgina Armstrong,Yanhong Liu,Robert Yu,Ching C. Lau,Maria Chiara Di Bernardo,Lindsay B. Robertson,Kenneth Muir,S. J. Hepworth,Anthony J. Swerdlow,Minouk J. Schoemaker,H.-Erich Wichmann,Martina Müller,Stefan Schreiber,Andre Franke,Susanne Moebus,Lewin Eisele,Asta Försti,Kari Hemminki,Mark Lathrop,Melissa L. Bondy,Richard S. Houlston,Matthias Simon +42 more
TL;DR: Findings show that variation in 7p11.2 is a determinant of inherited glioma risk, independent of tumor subtype, and independent of EGFR amplification, p16INK4a deletion and IDH1 mutation status in tumors; compatible with driver effects of the variants on gliomas development.