Xin Zhou

TL;DR: The research revealed that the complete lignin biosynthesis pathway first appeared in moss; the pathway is absent in green algae, and the rapid expansion of lignIn biosynthesis genes indicated that the translation of transgenic lIGNin modification strategies from model species to bioenergy feedstock might only be successful between the closely relevant species within the same family.

TL;DR: The WashU Epigenome Browser is extended, which currently hosts thousands of epigenome and transcriptome data sets for multiple cell types, tissues, individuals and species, to support multiple types of long-range genome interaction data, consistent with the hypothesis that chromatin domains are stable across cell types but can have different epigenetic profiles in different cells.

TL;DR: Examination of genome-wide DNA methylation status within 928 TE subfamilies in human embryonic and adult tissues identified unexpected tissue-specific and subfamily-specific hypomethylation signatures, suggesting sequences derived from TEs may be responsible for wiring tissue type–specific regulatory networks and may have acquired tissue- specific epigenetic regulation.

TL;DR: It is shown that the combination of a WEE1 inhibitor (AZD1775), irinotecan, and vincristine can lead to complete response in multiple rhabdomyosarcoma orthotopic patient-derived xenografts tumours in vivo.

TL;DR: In the developing retina, multipotent neural progenitors undergo unidirectional differentiation in a precise spatiotemporal order as mentioned in this paper, and the most dramatic change was derepression of cell-type-specific differentiation programs.