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Xin Zhou
Researcher at St. Jude Children's Research Hospital
Publications - 262
Citations - 17637
Xin Zhou is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Computer science & Medicine. The author has an hindex of 36, co-authored 71 publications receiving 13444 citations. Previous affiliations of Xin Zhou include Rice University & Washington University in St. Louis.
Papers
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Journal ArticleDOI
Retinal Cell Type DNA Methylation and Histone Modifications Predict Reprogramming Efficiency and Retinogenesis in 3D Organoid Cultures
Lu Wang,Daniel J. Hiler,Beisi Xu,Issam Aldiri,Xiang Chen,Xin Zhou,Lyra Griffiths,Marc Valentine,Abbas Shirinifard,Andras Sablauer,Suresh Thiagarajan,Marie E. Barabas,Jiakun Zhang,Dianna A. Johnson,Sharon Frase,Michael A. Dyer,Michael A. Dyer,Michael A. Dyer +17 more
TL;DR: Neurons with the lowest reprogramming efficiency produced iPSC lines with the best retinal differentiation and were more likely to retain epigenetic memory of their cellular origins.
Journal ArticleDOI
Clinical genome sequencing uncovers potentially targetable truncations and fusions of MAP3K8 in spitzoid and other melanomas
Scott Newman,Liying Fan,Allison Pribnow,Allison Pribnow,Antonina Silkov,Stephen V. Rice,Seungjae Lee,Ying Shao,Bridget Shaner,Heather L. Mulder,Joy Nakitandwe,Sheila A. Shurtleff,Elizabeth M Azzato,Gang Wu,Xin Zhou,Raymond L. Barnhill,John Easton,Kim E. Nichols,David W. Ellison,James R. Downing,Alberto S. Pappo,Philip M. Potter,Jinghui Zhang,Armita Bahrami +23 more
TL;DR: Rearrangements in MAP3K8 respond to MEK inhibition and represent the most common genetic driver in pediatric spitzoid melanoma, and in some adult melanomas lacking other MAPK alterations and for which clinical testing is warranted.
Journal ArticleDOI
Genomes for Kids: The scope of pathogenic mutations in pediatric cancer revealed by comprehensive DNA and RNA sequencing.
Scott Newman,Joy Nakitandwe,Chimene Kesserwan,Elizabeth M Azzato,David A. Wheeler,Michael Rusch,Sheila A. Shurtleff,Dale Hedges,Kayla V. Hamilton,Scott G. Foy,Michael N. Edmonson,Andrew Thrasher,Armita Bahrami,Brent A. Orr,Jeffery M. Klco,Jiali Gu,Lynn W. Harrison,Lu Wang,Michael R. Clay,Annastasia A. Ouma,Antonina Silkov,Yanling Liu,Zhaojie Zhang,Yu Liu,Samuel W. Brady,Xin Zhou,Ti-Cheng Chang,Manjusha Pande,Eric Davis,Jared Becksfort,Aman Patel,Mark R. Wilkinson,Delaram Rahbarinia,Manish Kubal,Jamie L. Maciaszek,Victor B Pastor,Jay Knight,Alexander M. Gout,Jian Wang,Zhaohui Gu,Charles G. Mullighan,Rose B. McGee,Emily Quinn,Regina Nuccio,Roya Mostafavi,Elsie L. Gerhardt,Leslie Taylor,Jessica M. Valdez,Stacy Hines-Dowell,Alberto S. Pappo,Giles W. Robinson,Liza-Marie Johnson,Ching-Hon Pui,David W. Ellison,James R. Downing,Jinghui Zhang,Kim E. Nichols +56 more
TL;DR: In this article, a three-platform sequencing approach, including whole genome (WGS), exome, and RNA sequencing, was used to examine tumor and germline genomes from 309 prospectively identified children with newly diagnosed (85%) or relapsed/refractory (15%) cancers, unselected for tumor type.
Journal ArticleDOI
The genomic landscape of pediatric acute lymphoblastic leukemia
Samuel W. Brady,Kathryn G. Roberts,Zhaohui Xu,Lei Shi,Stanley Pounds,Deqing Pei,Chen Chen,Yun Feng Dai,Meenakshi Devidas,Chun-Mei Qu,Ashley N Hill,Debbie Payne-Turner,Xiaotu Ma,Ilaria Iacobucci,Pradyuamna Baviskar,Lei Wei,Sasi Arunachalam,Kohei Hagiwara,Yanling Liu,Diane Flasch,Yu Liu,Matthew Parker,Xiaolong Chen,Abdelrahman H Elsayed,Omkar Pathak,Yongjin Li,Yiping Fan,J. Robert Michael,Michael Rusch,Mark R. Wilkinson,Scott G. Foy,Dale J. Hedges,Scott Newman,Xin Zhou,Jian Wang,Colleen Reilly,Edgar Sioson,Stephen V. Rice,V.B. Pastor Loyola,Gang Wu,Evadnie Rampersaud,Shalini C. Reshmi,Julie M. Gastier-Foster,Jaime M. Guidry Auvil,Patee Gesuwan,Malcolm A. Smith,Naomi J. Winick,Andrew J. Carroll,Nyla A. Heerema,Richard P. Harvey,Cheryl L. Willman,Eric Larsen,Elizabeth A. Raetz,Michael Horowitz,Brent L. Wood,William L. Carroll,Patrick A. Zweidler-McKay,Karen R. Rabin,Leonard A. Mattano,Kelly W. Maloney,S. Winter,Michael J. Burke,Wanda L. Salzer,Kimberly P. Dunsmore,Anne L. Angiolillo,Kristine R. Crews,James R. Downing,Sima Jeha,Ching-Hon Pui,William E. Evans,Jun Yang,Mary V. Relling,Daniela S. Gerhard,Mignon L. Loh,Stephen P. Hunger,Jinghui Zhang,Charles G. Mullighan +76 more
TL;DR: In this article , a genomic and transcriptomic analysis of 2,754 childhood acute lymphoblastic leukemias identifies 376 putative driver genes, and associations between disease subtypes and prognosis.
Posted ContentDOI
St. Jude Cloud—a Pediatric Cancer Genomic Data Sharing Ecosystem
Clay McLeod,Alexander M. Gout,Xin Zhou,Delaram Rahbarinia,Andrew Thrasher,Scott Newman,Kirby Birch,Michael Macias,David Finkelstein,Jobin Sunny,Rahul Mudunuri,Brent A. Orr,Madison Treadway,Bob Davidson,Tracy Ard,Andrew Swistak,Stephanie Wiggins,Scott G. Foy,Samuel W. Brady,Jian Wang,Edgar Sioson,Shuoguo Wang,J. Robert Michael,Yu Liu,Xiaotu Ma,Aman Patel,Michael N. Edmonson,Mark R. Wilkinson,Andrew Frantz,Ti-Cheng Chang,Liqing Tian,Shaohua Lei,Christopher P. Meyer,Naina Thangaraj,Pamella Tater,Vijay Kandali,Singer Ma,Tuan Nguyen,Omar Serang,Irina McGuire,Nedra Robison,Darrell Gentry,Xing Tang,Lance E. Palmer,Gang Wu,Ed Suh,Leigh Tanner,James McMurry,Matthew Lear,Zhaoming Wang,Carmen L. Wilson,Yong Cheng,Mitch Weiss,Gregory T. Armstrong,Leslie L. Robison,Yutaka Yasui,Kim E. Nichols,David W. Ellison,Chitanya Bangur,Charles G. Mullighan,Suzanne J. Baker,Michael A. Dyer,Geralyn Miller,Michael Rusch,Richard Daly,Keith Perry,James R. Downing,Jinghui Zhang +67 more
TL;DR: The value of the St. Jude Cloud ecosystem is demonstrated through use cases that classify 48 pediatric cancer subtypes by gene expression profiling and map mutational signatures across 35 subtypes of pediatric cancer.