Xin Zhou

TL;DR: This work combined MeDIP-seq with methylation-sensitive restriction enzyme (MRE-seq) sequencing for comprehensive methylome coverage at lower cost and detected regions with allele-specific epigenetic states, identifying most known imprinted regions and new loci with Monoallelic epigenetic marks and monoallelic expression.

TL;DR: Using integrated genomic analysis of 264 T-ALL cases, 106 putative driver genes are identified and new mechanisms of coding and noncoding alteration are described, which suggests that different signaling pathways have distinct roles according to maturational stage.

TL;DR: A pan-cancer study of somatic alterations, including single nucleotide variants, small insertions or deletions, structural variations, copy number alterations, gene fusions and internal tandem duplications in 1,699 paediatric leukaemias and solid tumours across six histotypes, provides a comprehensive genomic architecture for paediatric cancers.

TL;DR: It is proposed that AGO10 functions as a decoy for miR166/165 to maintain the SAM, preventing their incorporation into AGO1 complexes and the subsequent repression of HD-ZIP III gene expression.

TL;DR: The plant miRNA database (PMRD) integrates available plant miRNAs data deposited in public databases, gleaned from the recent literature, and data generated in-house, and contains sequence information, secondary structure, target genes, expression profiles and a genome browser.