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Xin Zhou
Researcher at St. Jude Children's Research Hospital
Publications - 262
Citations - 17637
Xin Zhou is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Computer science & Medicine. The author has an hindex of 36, co-authored 71 publications receiving 13444 citations. Previous affiliations of Xin Zhou include Rice University & Washington University in St. Louis.
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Journal ArticleDOI
A community approach to the cancer-variant-interpretation bottleneck
Kilannin Krysiak,Arpad Danos,Susanna Kiwala,Joshua F. McMichael,Adam C. Coffman,Erica K. Barnell,Lana Sheta,Jason Saliba,Cameron J. Grisdale,Lynzey Kujan,Shahil Pema,Jake Lever,Nicholas C. Spies,Andreea Chiorean,Damian T. Rieke,Kaitlin Clark,Payal Jani,Hideaki Takahashi,Peter Horak,Deborah I. Ritter,Xin Zhou,Benjamin J. Ainscough,Sean Delong,Mario Lamping,Alex Marr,Brian Li,Wan-Hsin Lin,Panieh Terraf,Yasser Salama,Katie M. Campbell,Kirsten M. Farncombe,Jianling Ji,Xiao-li Zhao,Xinjie Xu,Rashmi Kanagal-Shamanna,Kelsy C. Cotto,Zachary L. Skidmore,Jason Walker,Jinghui Zhang,Aleksandar Milosavljevic,Ronak Y. Patel,Rachel H. Giles,Raymond H. Kim,Lynn M. Schriml,Elaine R. Mardis,Steven J.M. Jones,Gordana Raca,Shruti Rao,Subhashree Madhavan,Alex H. Wagner,Obi L. Griffith,Malachi Griffith +51 more
TL;DR: CIViC as mentioned in this paper is a public-domain, crowd-sourced and adaptable knowledgebase of evidence for the clinical interpretation of variants in cancer, designed to reduce barriers to knowledge sharing and alleviate the variant-interpretation bottleneck.
Journal ArticleDOI
C-terminal truncation modulates α-Synuclein’s cytotoxicity and aggregation by promoting the interactions with membrane and chaperone
Caie Zhang,Yun Pei,Zeting Zhang,Lingling Xu,Xiaoli Liu,Ling Jiang,Gary J. Pielak,Xin Zhou,Maili Liu,Conggang Li +9 more
TL;DR: In this paper , the authors used nuclear magnetic resonance spectroscopy to show that the truncation alters α-syn conformation, resulting in an attractive interaction of the N-terminus with membranes and molecular chaperone, protein disulfide isomerase (PDI).
Journal ArticleDOI
The Genomic Landscape of Childhood Acute Lymphoblastic Leukemia
Kathryn G. Roberts,Samuel W. Brady,Zhaohui Gu,Lei Shi,Stanley Pounds,Deqing Pei,Cheng Cheng,Yunfeng Dai,Meenakshi Devidas,Chunxu Qu,Ashley Hill,Xiaotu Ma,Lei Wei,Sasi Arunachalam,Kohei Hagiwara,Yangling Liu,Diane Flasch,Yu Liu,Matthew Parker,Xiao-Long Chen,Yongjin Li,Yiping Fan,Robert Michael,Michael Rusch,Mark R. Wilkinson,Scott G. Foy,Dale Hedges,Scott Newman,Xin Zhou,Jian Wang,Shalini C. Reshmi,Julie M. Gastier-Foster,Patee Gesuwan,Malcolm A. Smith,Daniela S. Gerhard,Naomi J. Winick,Andrew J. Carroll,Nyla A. Heerema,Richard C. Harvey,Cheryl L. Willman,Eric Larsen,Elizabeth A. Raetz,Michael J. Borowitz,Brent L. Wood,William L. Carroll,Patrick A. Zweidler-McKay,Karen R. Rabin,Leonard A. Mattano,Kelly W. Maloney,Stuart S. Winter,Michael J. Burke,Wanda L. Salzer,Kimberly P. Dunsmore,Anne L. Angiolillo,Kristine R. Crews,James R. Downing,Sima Jeha,William E. Evans,Ching-Hon Pui,Jun J. Yang,Mary V. Relling,Stephen P. Hunger,Mignon L. Loh,Jinghui Zhang,Charles G. Mullighan +64 more
TL;DR: A comprehensive integration of significantly mutated genes and pathways for each subgroup is needed to understand disease etiology of B-progenitor and T-lineage acute lymphoblastic leukemia.
Posted ContentDOI
The Myogenesis Program Drives Clonal Selection and Drug Resistance in Rhabdomyosarcoma
Anand G. Patel,Xiang Chen,Huang X,Clay Mr,Natalia L. Komarova,Matthew J. Krasin,Alberto S. Pappo,Heather Tillman,Brent A. Orr,Justina McEvoy,Brittney Gordon,Kaley Blankenship,Colleen Reilly,Xin Zhou,Jackie L. Norrie,Asa Karlstrom,Jiyang Yu,Dominik Wodarz,Elizabeth Stewart,Michael A. Dyer +19 more
TL;DR: In this paper, single cell and single nucleus RNA-sequencing was used to show that RMS tumors recapitulate the spectrum of embryonal myogenesis and that targeting each developmental state in RMS is an effective strategy for improving outcomes by preventing disease recurrence.
Journal ArticleDOI
Numerical simulation to assess the impact of urban green infrastructure on building energy use: A review
TL;DR: In this article , the authors present a review of the research conducted on UGI modeling in numerical simulations of building energy consumption over the past 35 years and outlined the general workflow of these simulations.