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Robert W. Schnepp
Researcher at Emory University
Publications - 36
Citations - 2583
Robert W. Schnepp is an academic researcher from Emory University. The author has contributed to research in topics: Neuroblastoma & MEN1. The author has an hindex of 17, co-authored 29 publications receiving 2341 citations. Previous affiliations of Robert W. Schnepp include Harvard University & Janssen Pharmaceutica.
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Journal ArticleDOI
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors
Thomas A. Milne,Christina M. Hughes,Ricardo V. Lloyd,Zhaohai Yang,Orit Rozenblatt-Rosen,Yali Dou,Robert W. Schnepp,Cynthia Krankel,Virginia A. LiVolsi,Denise Gibbs,Xianxin Hua,Robert G. Roeder,Matthew Meyerson,Jay L. Hess +13 more
TL;DR: It is shown that menin directly regulates expression of the cyclin-dependent kinase inhibitors p27Kip1 and p18Ink4c and plays a central role in menin's activity as a tumor suppressor.
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Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma
JulieAnn Rader,Mike R. Russell,Lori S. Hart,Michael S. Nakazawa,Lili T. Belcastro,Daniel Martinez,Yimei Li,Erica L. Carpenter,Edward F. Attiyeh,Sharon J. Diskin,Sunkyu Kim,Sudha Parasuraman,Giordano Caponigro,Robert W. Schnepp,Andrew C. Wood,Bruce R. Pawel,Kristina A. Cole,John M. Maris +17 more
TL;DR: The data show that LEE011 is active in a large subset of neuroblastoma cell line and xenograft models, and supports the clinical development of this CDK4/6 inhibitor as a therapy for patients with this disease.
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Integrative genomics identifies LMO1 as a neuroblastoma oncogene
Kai Wang,Kai Wang,Sharon J. Diskin,Haitao Zhang,Edward F. Attiyeh,Cynthia Winter,Cuiping Hou,Robert W. Schnepp,Maura Diamond,Kristopher R. Bosse,Patrick A. Mayes,Joseph T. Glessner,Cecilia Kim,Edward C. Frackelton,Maria Garris,Qun Wang,Wendy Glaberson,Rosetta M. Chiavacci,Le Nguyen,Le Nguyen,Jayanti Jagannathan,Norihisa Saeki,Hiroki Sasaki,Struan F.A. Grant,Struan F.A. Grant,Achille Iolascon,Yael P. Mosse,Yael P. Mosse,Kristina A. Cole,Kristina A. Cole,Hongzhe Li,Marcella Devoto,Patrick McGrady,Wendy B. London,Mario Capasso,Nazneen Rahman,Hakon Hakonarson,Hakon Hakonarson,John M. Maris,John M. Maris +39 more
TL;DR: Data show that common polymorphisms at the LMO1 locus are strongly associated with susceptibility to developing neuroblastoma, but also may influence the likelihood of further somatic alterations at this locus, leading to malignant progression.
Journal ArticleDOI
Hop is an unusual homeobox gene that modulates cardiac development.
Fabian Chen,Hyun Kook,Rita K. Milewski,Aaron D. Gitler,Min Min Lu,Jun Li,Ronniel Nazarian,Robert W. Schnepp,Kuang-Yu Jen,Christine Biben,Greg Runke,Joel P. Mackay,Jiri Novotny,Robert J. Schwartz,Richard P. Harvey,Richard P. Harvey,Mary C. Mullins,Jonathan A. Epstein +17 more
TL;DR: Genetic and biochemical data indicate that Hop functions directly downstream of Nkx2-5, and encodes an unusual homeodomain protein that modulates SRF-dependent cardiac-specific gene expression and cardiac development.
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Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma
Sharon J. Diskin,Mario Capasso,Robert W. Schnepp,Kristina A. Cole,Kristina A. Cole,Edward F. Attiyeh,Edward F. Attiyeh,Cuiping Hou,Maura Diamond,Erica L. Carpenter,Cynthia Winter,Hanna Lee,Jayanti Jagannathan,Valeria Latorre,Valeria Latorre,Achille Iolascon,Hakon Hakonarson,Hakon Hakonarson,Marcella Devoto,John M. Maris +19 more
TL;DR: Data show that common variants in HACE1 and LIN28B influence neuroblastoma susceptibility and indicate that both genes likely have a role in disease progression.