Qingfa Wu

TL;DR: A new role for circRNAs in regulating gene expression in the nucleus is revealed, in which EIciRNAs enhance the expression of their parental genes in cis, and a regulatory strategy for transcriptional control via specific RNA-RNA interaction between U1 snRNA and EICIRNAs is highlighted.

TL;DR: This study provides a powerful culture-independent approach for virus discovery in invertebrates by assembling viral genomes directly from host immune response products without prior virus enrichment or amplification, and proposes that invertebrate viruses discovered by this approach may include previously undescribed human and vertebrate viral pathogens that are transmitted by arthropod vectors.

TL;DR: This work identifies a distinct mechanism for the amplification of immunity effectors, which together with the requirement for the biogenesis of endogenous siRNAs, may play a role in the emergence and expansion of eukaryotic RDRs.

TL;DR: This work identifies cooperative action of ARGONAUTE1 and ARGonAUTE2 in virus resistance conferred by 21-nucleotide virus-derived small interfering RNAs (siRNAs) and reveals that 22- nucleotide viral siRNAs do not guide efficient antiviral defense, demonstrating a qualitative difference between 21- and 22-Nucleotide classes ofSiRNAs in RNA silencing.

TL;DR: It is suggested that there is a high birth rate of new miRNA genes, accompanied by a comparably high death rate in Drosophila, and that a small fraction of surviving miRNAs may later on become moderately or highly expressed.