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Yang W. Shao
Researcher at Nanjing Medical University
Publications - 116
Citations - 2355
Yang W. Shao is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 18, co-authored 57 publications receiving 1343 citations.
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Journal ArticleDOI
Investigating Novel Resistance Mechanisms to Third-Generation EGFR Tyrosine Kinase Inhibitor Osimertinib in Non–Small Cell Lung Cancer Patients
Zhe Yang,Nong Yang,Qiuxiang Ou,Yi Xiang,Tao Jiang,Xue Wu,Hua Bao,Xiaoling Tong,Xiaonan Wang,Yang W. Shao,Yunpeng Liu,Yan Wang,Caicun Zhou +12 more
TL;DR: Novel secondary mutations of EGFR L718 and L792 residues confer osimertinib resistance, both in vitro and in vivo, and are of great clinical and pharmaceutical relevance.
Journal ArticleDOI
Widespread and Functional RNA Circularization in Localized Prostate Cancer
Sujun Chen,Sujun Chen,Sujun Chen,Vincent Huang,Xin Xu,Julie Livingstone,Fraser Soares,Jouhyun Jeon,Yong Zeng,Junjie Tony Hua,Junjie Tony Hua,Jessica Petricca,Jessica Petricca,Haiyang Guo,Miranda Wang,Fouad Yousif,Yuzhe Zhang,Yuzhe Zhang,Yuzhe Zhang,Nilgun Donmez,Musaddeque Ahmed,Stas Volik,Anna Lapuk,Melvin L.K. Chua,Lawrence E. Heisler,Adrien Foucal,Natalie S. Fox,Natalie S. Fox,Michael Fraser,Michael Fraser,Vinayak Bhandari,Vinayak Bhandari,Yu Jia Shiah,Jiansheng Guan,Jiansheng Guan,Jixi Li,Michèle Orain,Valérie Picard,Hélène Hovington,Alain Bergeron,Louis Lacombe,Yves Fradet,Bernard Têtu,Stanley K. Liu,Stanley K. Liu,Felix Y. Feng,Xue Wu,Yang W. Shao,Malgorzata A. Komor,Malgorzata A. Komor,Cenk Sahinalp,Colin Collins,Colin Collins,Youri Hoogstrate,Mark de Jong,Remond J.A. Fijneman,Teng Fei,Guido Jenster,Theodorus van der Kwast,Theodorus van der Kwast,Robert G. Bristow,Paul C. Boutros,Housheng Hansen He,Housheng Hansen He +63 more
TL;DR: Ultra-deep total RNA-seq on 144 tumors with rich clinical annotation revealed a linear transcriptomic subtype associated with the aggressive intraductal carcinoma sub-histology and a fusion profile that differentiates localized from metastatic disease.
Journal ArticleDOI
Circulating Tumor DNA Mutation Profiling by Targeted Next Generation Sequencing Provides Guidance for Personalized Treatments in Multiple Cancer Types.
Yongqian Shu,Xue Wu,Xiaoling Tong,Xiaonan Wang,Zhili Chang,Yu Mao,Xiaofeng Chen,Jing Sun,Zhenxin Wang,Zhuan Hong,Liangjun Zhu,Chunrong Zhu,Jun Chen,Ying Liang,Huawu Shao,Yang W. Shao +15 more
TL;DR: A unique mutation spectrum in Chinese lung cancer patients is revealed which could be used to guide treatment decisions and monitor drug-resistant mutations.
Journal ArticleDOI
Comprehensive Genomic Profiling Identifies Novel Genetic Predictors of Response to Anti-PD-(L)1 Therapies in Non-Small Cell Lung Cancer
Wenfeng Fang,Yuxiang Ma,Jiani C. Yin,Shaodong Hong,Huaqiang Zhou,Ao Wang,Fufeng Wang,Hua Bao,Xue Wu,Yunpeng Yang,Yan Huang,Hongyun Zhao,Yang W. Shao,Li Zhang +13 more
TL;DR: The findings suggest that comprehensive profiling of TMB and the aforementioned molecular markers could result in greater predictive power of response to ICI therapies in NSCLC.
Journal ArticleDOI
Liquid Biopsies to Track Trastuzumab Resistance in Metastatic HER2-positive Gastric Cancer
De Shen Wang,Zexian Liu,Yun Xin Lu,Hua Bao,Xue Wu,Zhao Lei Zeng,Zekun Liu,Qi Zhao,Cai Yun He,Jia Huan Lu,Zhi Qiang Wang,Miao Zhen Qiu,Feng Wang,Feng Hua Wang,Yu Hong Li,Xiao Nan Wang,Dan Xie,Wei Hua Jia,Yang W. Shao,Rui-Hua Xu +19 more
TL;DR: Longitudinal circulating tumour DNA sequencing provides novel insights into gene alterations underlying trastuzumab resistance in HER2+mGC.