Y
Yang Yu
Researcher at Harbin Medical University
Publications - 162
Citations - 3847
Yang Yu is an academic researcher from Harbin Medical University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 29, co-authored 118 publications receiving 3045 citations. Previous affiliations of Yang Yu include University of Texas MD Anderson Cancer Center & Baylor College of Medicine.
Papers
More filters
Journal ArticleDOI
Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion
Xiangning Meng,Yan Jin,Yang Yu,Jing Bai,Liu Gy,Jiang Zhu,Yanling Zhao,Wang Z,Feng Chen,Ki-Young Lee,Songbin Fu +10 more
TL;DR: F fibronectin-mediated activation of FAK that leads to lung cancer metastasis could occur through ERK or PI3K/Akt regulation of MMP9/calpain-2 or M MP9/RhoA activity, respectively.
Journal ArticleDOI
Lysine 63-linked Polyubiquitination of TAK1 at Lysine 158 Is Required for Tumor Necrosis Factor α- and Interleukin-1β-induced IKK/NF-κB and JNK/AP-1 Activation
Yihui Fan,Yihui Fan,Yang Yu,Yang Yu,Yi Shi,Wenjing Sun,Min Xie,Ningling Ge,Renfang Mao,Alex L. Chang,Gufeng Xu,Michael D. Schneider,Michael D. Schneider,Hong Zhang,Songbin Fu,Jun Qin,Jianhua Yang +16 more
TL;DR: These findings demonstrate that Lys63-linked polyubiquitination of TAK1 at Lys158 is essential for its own kinase activation and its ability to mediate its downstream signal transduction pathways in response to TNFα and IL-1β stimulation.
Journal ArticleDOI
USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis
Yihui Fan,Jin Cheng,Sanjeev A. Vasudevan,Jun Dou,Jun Dou,Hong Zhang,Roma H. Patel,I. T. Ma,Yesenia Rojas,Yi-Jue Zhao,Yang Yu,Jason M. Shohet,Jed G. Nuchtern,Eugene S. Kim,Jianhua Yang +14 more
TL;DR: It is reported that the ubiquitin-specific protease 7 (USP7) inhibitor, P22077, potently induces apoptosis in NB cells with an intact USP7-HDM2-p53 axis but not inNB cells with mutant p53 or without human homolog of MDM2 ( HDM2) expression.
Journal ArticleDOI
USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase.
Yihui Fan,Renfang Mao,Yang Yu,Shangfeng Liu,Zhongcheng Shi,Jin Cheng,Huiyuan Zhang,Lei An,Yanling Zhao,Xin Xu,Zhenghu Chen,Mari Kogiso,Dekai Zhang,Hong Zhang,Hong Zhang,Pumin Zhang,Jae U. Jung,Xiao-Nan Li,Guo-Tong Xu,Jianhua Yang +19 more
TL;DR: The deubiquitinase USP21 targets RIG-I for deubiqueitination, thus dampening interferon production and activation of IFN-responsive genes in response to RNA viruses.
Journal ArticleDOI
PPM1A and PPM1B act as IKKβ phosphatases to terminate TNFα-induced IKKβ-NF-κB activation
Wenjing Sun,Yang Yu,Gianpietro Dotti,Tao Shen,Xiaojie Tan,Barbara Savoldo,Amy K. Pass,Meijin Chu,Dekai Zhang,Xiongbin Lu,Songbin Fu,Xia Lin,Jianhua Yang +12 more
TL;DR: PPM1A and PPM1B play an important role in the termination of TNFalpha-mediated NF-kappaB activation through dephosphorylating and inactivating IKKbeta.