Y
Yaozhong Zou
Researcher at Stanford University
Publications - 9
Citations - 4309
Yaozhong Zou is an academic researcher from Stanford University. The author has contributed to research in topics: G protein-coupled receptor & Receptor. The author has an hindex of 7, co-authored 9 publications receiving 3839 citations.
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Journal ArticleDOI
Crystal structure of the β2 adrenergic receptor-Gs protein complex.
Søren G. F. Rasmussen,Brian T. DeVree,Yaozhong Zou,Andrew C. Kruse,Ka Young Chung,Tong Sun Kobilka,Foon Sun Thian,Pil Seok Chae,Els Pardon,Els Pardon,Diane M. Calinski,Jesper Mosolff Mathiesen,Syed T. A. Shah,Joseph A. Lyons,Martin Caffrey,Samuel H. Gellman,Jan Steyaert,Jan Steyaert,Georgios Skiniotis,William I. Weis,Roger K. Sunahara,Brian K. Kobilka +21 more
TL;DR: This crystal structure represents the first high-resolution view of transmembrane signalling by a GPCR and the most surprising observation is a major displacement of the α-helical domain of Gαs relative to the Ras-like GTPase domain.
Journal ArticleDOI
The Dynamic Process of β2-Adrenergic Receptor Activation
Rie Nygaard,Yaozhong Zou,Ron O. Dror,Thomas J. Mildorf,Daniel H. Arlow,Aashish Manglik,Albert C. Pan,Corey W. Liu,Juan Jose Fung,Michael P. Bokoch,Foon Sun Thian,Tong Sun Kobilka,David E. Shaw,Luciano Mueller,R. Scott Prosser,Brian K. Kobilka +15 more
TL;DR: NMR spectroscopy is used to characterize the conformational dynamics of the transmembrane core of the β(2)-adrenergic receptor (β(2)AR), a prototypical GPCR, and shows that for β( 2)AR, unlike rhodopsin, an agonist alone does not stabilize a fully active conformation.
Journal ArticleDOI
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
Michael P. Bokoch,Yaozhong Zou,Søren G. F. Rasmussen,Corey W. Liu,Rie Nygaard,Daniel M. Rosenbaum,Juan Jose Fung,Hee Jung Choi,Foon Sun Thian,Tong Sun Kobilka,Joseph D. Puglisi,William I. Weis,Leonardo Pardo,R. Scott Prosser,Luciano Mueller,Brian K. Kobilka +15 more
TL;DR: NMR spectroscopy is used to demonstrate conformational coupling between the ECS and the orthosteric binding site, showing that drugs targeting this diverse surface could function as allosteric modulators with high subtype selectivity.
The Dynamic Process of b 2 -Adrenergic Receptor Activation
Rie Nygaard,Yaozhong Zou,Ron O. Dror,Thomas J. Mildorf,Daniel H. Arlow,Aashish Manglik,Albert C. Pan,Corey W. Liu,Michael P. Bokoch,Foon Sun Thian,Tong Sun Kobilka,David E. Shaw,Luciano Mueller,R. Scott Prosser,Brian K. Kobilka +14 more
TL;DR: In this paper, NMR spectroscopy was used to characterize the conformational dynamics of the transmembrane core of the b2-adrenergic receptor (b2AR), a prototypical GPCR.
Journal ArticleDOI
Structural insights into binding specificity, efficacy and bias of a beta2AR partial agonist.
Matthieu Masureel,Yaozhong Zou,Louis Picard,Emma T van der Westhuizen,Emma T van der Westhuizen,Jacob P. Mahoney,João P. G. L. M. Rodrigues,Thomas J. Mildorf,Ron O. Dror,David E. Shaw,Michel Bouvier,Els Pardon,Jan Steyaert,Roger K. Sunahara,William I. Weis,Cheng Zhang,Brian K. Kobilka +16 more
TL;DR: The active-state structure of a GPCR occupied by a partial agonist, β2AR with salmeterol, together with mutagenesis and biophysical studies, explains this ligand's unusual pharmacological profile.