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Yasuko Hisano
Researcher at RIKEN Brain Science Institute
Publications - 19
Citations - 438
Yasuko Hisano is an academic researcher from RIKEN Brain Science Institute. The author has contributed to research in topics: Allele & FABP7. The author has an hindex of 9, co-authored 19 publications receiving 295 citations.
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Journal ArticleDOI
Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies
Chie Shimamoto,Tetsuo Ohnishi,Motoko Maekawa,Akiko Watanabe,Hisako Ohba,Ryoichi Arai,Yoshimi Iwayama,Yasuko Hisano,Tomoko Toyota,Manabu Toyoshima,Katsuaki Suzuki,Yukihiko Shirayama,Kazuhiko Nakamura,Norio Mori,Yuji Owada,Tetsuyuki Kobayashi,Takeo Yoshikawa +16 more
TL;DR: In conclusion, disturbances in brain-expressed FABPs could represent an underlying disease mechanism in a proportion of schizophrenia and ASD sufferers.
Journal ArticleDOI
Analysis of induced pluripotent stem cells carrying 22q11.2 deletion
Manabu Toyoshima,Wado Akamatsu,Wado Akamatsu,Yohei Okada,Yohei Okada,Tetsuo Ohnishi,Shabeesh Balan,Yasuko Hisano,Yoshimi Iwayama,Tomoko Toyota,Takuya Matsumoto,N Itasaka,S Sugiyama,Mika Tanaka,Masato Yano,Brian Dean,Hideyuki Okano,Takeo Yoshikawa +17 more
TL;DR: The results suggest that a dysregulated balance of neurogenic-to-gliogenic competence may underlie neurodevelopmental disorders such as schizophrenia.
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Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes
Motoko Maekawa,Akiko Watanabe,Yoshimi Iwayama,T Kimura,Kei Hamazaki,Shabeesh Balan,Hisako Ohba,Yasuko Hisano,Yayoi Nozaki,Tetsuo Ohnishi,Manabu Toyoshima,Chie Shimamoto,Kazuya Iwamoto,Miki Bundo,Noriko Osumi,E Takahashi,Akihiko Takashima,Akihiko Takashima,Takeo Yoshikawa +18 more
TL;DR: It is shown that gestational and early postnatal dietary deprivation of two PUFAs—arachidonic acid (AA) and docosahexaenoic acid (DHA)—elicited schizophrenia-like phenotypes in mouse offspring at adulthood, suggesting that PUFA deficiency during the early neurodevelopmental period in mice could model the prodromal state of schizophrenia through changes in the epigenetic regulation of nuclear receptor genes.
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Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology
Masayuki Ide,Tetsuo Ohnishi,Manabu Toyoshima,Shabeesh Balan,Motoko Maekawa,Chie Shimamoto-Mitsuyama,Yoshimi Iwayama,Hisako Ohba,Akiko Watanabe,Takashi Ishii,Norihiro Shibuya,Yuka Kimura,Yasuko Hisano,Yui Murata,Tomonori Hara,Momo Morikawa,Kenji Hashimoto,Yayoi Nozaki,Tomoko Toyota,Yuina Wada,Yosuke Tanaka,Tadafumi Kato,Akinori Nishi,Shigeyoshi Fujisawa,Hideyuki Okano,Masanari Itokawa,Nobutaka Hirokawa,Yasuto Kunii,Akiyoshi Kakita,Hirooki Yabe,Kazuya Iwamoto,Kohji Meno,Takuya Katagiri,Brian Dean,Brian Dean,Kazuhiko Uchida,Hideo Kimura,Takeo Yoshikawa +37 more
TL;DR: The results suggest that inflammatory/oxidative insults in early brain development result in upregulated H2S/polysulfides production as an antioxidative response, which in turn cause deficits in bioenergetic processes.
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Investigation of betaine as a novel psychotherapeutic for schizophrenia
Tetsuo Ohnishi,Shabeesh Balan,Manabu Toyoshima,Motoko Maekawa,Hisako Ohba,Akiko Watanabe,Yoshimi Iwayama,Yuko Fujita,Yunfei Tan,Yasuko Hisano,Chie Shimamoto-Mitsuyama,Yayoi Nozaki,Kayoko Esaki,Atsuko Nagaoka,Junya Matsumoto,Mizuki Hino,Nobuko Mataga,Akiko Hayashi-Takagi,Kenji Hashimoto,Yasuto Kunii,Akiyoshi Kakita,Hirooki Yabe,Takeo Yoshikawa +22 more
TL;DR: The presence of remnants of psychiatric behaviors along with schizophrenia-related molecular perturbations in the brain are revealed, supporting a causal link between betaine and oxidative stress conditions and underscores the potential benefit of betaine in a subset of schizophrenia.