Y
Yi-An Chen
Researcher at Artificial Intelligence Center
Publications - 21
Citations - 488
Yi-An Chen is an academic researcher from Artificial Intelligence Center. The author has contributed to research in topics: Data warehouse & Knowledge extraction. The author has an hindex of 10, co-authored 21 publications receiving 399 citations. Previous affiliations of Yi-An Chen include Osaka University.
Papers
More filters
Journal ArticleDOI
TargetMine, an Integrated Data Warehouse for Candidate Gene Prioritisation and Target Discovery
TL;DR: An objective protocol for target prioritisation using TargetMine is proposed and the results show that the protocol can identify known disease-associated genes with high precision and coverage.
Journal ArticleDOI
Targeting BIG3–PHB2 interaction to overcome tamoxifen resistance in breast cancer cells
Tetsuro Yoshimaru,Masato Komatsu,Taisuke Matsuo,Yi-An Chen,Yoichi Murakami,Yoichi Murakami,Kenji Mizuguchi,Eiichi Mizohata,Tsuyoshi Inoue,Miki Akiyama,Rui Yamaguchi,Seiya Imoto,Satoru Miyano,Yasuo Miyoshi,Mitsunori Sasa,Yusuke Nakamura,Yusuke Nakamura,Toyomasa Katagiri +17 more
TL;DR: A cell-permeable peptide inhibitor, called ERAP, that regulates multiple ERα-signalling pathways associated with tamoxifen resistance in breast cancer cells by inhibiting the interaction between BIG3 and PHB2 is reported.
Journal ArticleDOI
Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis
Shoichi Ihara,Hiroshi Kida,Hisashi Arase,Lokesh P. Tripathi,Yi-An Chen,Tetsuya Kimura,Mitsuhiro Yoshida,Yozo Kashiwa,Haruhiko Hirata,Reiko Fukamizu,Ruriko Inoue,Kana Hasegawa,Sho Goya,Ryo Takahashi,Toshiyuki Minami,Kazuyuki Tsujino,Mayumi Suzuki,Satoshi Kohmo,Koji Inoue,Izumi Nagatomo,Yoshito Takeda,Takashi Kijima,Kenji Mizuguchi,Isao Tachibana,Atsushi Kumanogoh +24 more
TL;DR: It is shown that Stat3 blunts rather than supports antitumor immunity in carcinogen-induced lung tumorigenesis, and human non-small cell lung cancer cells in which Stat3 was silenced displayed an enhancement of proinflammatory chemokine production, reduced expression of MHC class I antigen, and increased susceptibility to NK cell-mediated cytotoxicity.
Journal ArticleDOI
Impact of quality trimming on the efficiency of reads joining and diversity analysis of Illumina paired-end reads in the context of QIIME1 and QIIME2 microbiome analysis frameworks
TL;DR: Quality trimming increased the number of good reads and abundance measurement accuracy in Illumina paired-end reads of the V3-V4 hypervariable region and suggests that the pre-analysis trimming step should be included before the application of QIime1 or QIIME2.
Journal ArticleDOI
An integrative data analysis platform for gene set analysis and knowledge discovery in a data warehouse framework.
TL;DR: To enhance the scope of TargetMine from target prioritization to broad-based knowledge discovery, a new auxiliary toolkit to assist with data analysis and visualization in TargetMine is developed.