Yifang Hu

TL;DR: It is demonstrated that intestinal Treg cells upregulate the transcription factor c-Maf in response to specific signals from the gut microenvironment to establish host–microbiota homeostasis.

TL;DR: Monitoring the rate of change in neutrophil viability associated with activation of the Fas-triggered death receptor pathway using real-time cell imaging shows that the Bcl-2-related proteins Bid, Bax, and Bak accelerate neutrophils apoptosis but are not essential for cell death.

TL;DR: Haemopedia, an atlas of murine gene-expression data containing 54 hematopoietic cell types, covering all the mature lineages in he matopoiesis is presented, showing that lineage branching and maturation during hematoiesi can be reconstructed using the expression patterns of small sets of genes.

TL;DR: In this model, restoring endogenous Pax5 expression in established B-ALL triggers immunophenotypic maturation and durable disease remission by engaging a transcriptional program reminiscent of normal B-cell differentiation by impairing a differentiation program that can be re-engaged despite the presence of additional oncogenic lesions.

TL;DR: This work analyzed the miRNA profiles of samples with global miRNA decreases using Affymetrix miRNA microarrays following the inducible genetic deletion of Dicer1 and suggested that the use of cyclic loess based on non-miRNA small RNAs can help to improve the sensitivity and specificity of miRNA profiling in cancer samples withglobal miRNA decrease.