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Yifang Hu
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 35
Citations - 25473
Yifang Hu is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Haematopoiesis & Cellular differentiation. The author has an hindex of 23, co-authored 34 publications receiving 16561 citations. Previous affiliations of Yifang Hu include University of Melbourne.
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Journal ArticleDOI
Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects.
Alex R. D. Delbridge,Alex R. D. Delbridge,Andrew J. Kueh,Andrew J. Kueh,Francine Ke,Francine Ke,Natasha Zamudio,Farrah El-Saafin,Farrah El-Saafin,Natasha Jansz,Natasha Jansz,Gao-Yuan Wang,Gao-Yuan Wang,Megan Iminitoff,Tamara Beck,Sue Haupt,Sue Haupt,Yifang Hu,Rose E. May,Lachlan Whitehead,Lachlan Whitehead,Lin Tai,William Chiang,William Chiang,Marco J Herold,Marco J Herold,Ygal Haupt,Ygal Haupt,Gordon K. Smyth,Gordon K. Smyth,Tim Thomas,Tim Thomas,Marnie E. Blewitt,Marnie E. Blewitt,Andreas Strasser,Andreas Strasser,Anne K. Voss,Anne K. Voss +37 more
TL;DR: Findings suggest that p53 directly activates XIC genes, without which there is stochastic failure in X chromosome inactivation, and that X chromosomes inactivation failure may underlie the female bias in neural tube closure defects.
Journal ArticleDOI
Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia.
Matthew T. Witkowski,Luisa Cimmino,Yifang Hu,Thomas Trimarchi,Hiromi Tagoh,Mark D. McKenzie,Sarah A. Best,Laura Tuohey,Tracy A. Willson,Stewart L Nutt,Meinrad Busslinger,Ioannis Aifantis,Gordon K. Smyth,Ross A. Dickins +13 more
TL;DR: It is demonstrated for the first time that aberrant NOTCH activity compromises IKarOS function in mouse and human T-ALL, and a potential explanation for the relative infrequency of IKAROS gene mutations in human T -ALL is provided.
Journal ArticleDOI
Integration of microRNA signatures of distinct mammary epithelial cell types with their gene expression and epigenetic portraits
Bhupinder Pal,Bhupinder Pal,Yunshun Chen,Yunshun Chen,Andrew G. Bert,Yifang Hu,Julie Sheridan,Julie Sheridan,Tamara Beck,Tamara Beck,Wei Shi,Wei Shi,Keith Satterley,Paul R. Jamieson,Paul R. Jamieson,Gregory J. Goodall,Gregory J. Goodall,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Gordon K. Smyth,Gordon K. Smyth,Jane E. Visvader,Jane E. Visvader +23 more
TL;DR: The derivation of global miRNA expression profiles for the different mammary subpopulations provides a comprehensive resource for understanding the interplay between miRNA networks and target gene expression and suggests that key developmental miRNAs are regulated by global changes in histone modification.
Journal ArticleDOI
Early lineage priming by trisomy of Erg leads to myeloproliferation in a down syndrome model
Ashley P. Ng,Yifang Hu,Donald Metcalf,Craig D. Hyland,Helen Ierino,Belinda Phipson,Di Wu,Tracey M. Baldwin,Maria Kauppi,Hiu Kiu,Ladina Di Rago,Douglas J. Hilton,Gordon K. Smyth,Warren S. Alexander +13 more
TL;DR: A role for ERG as a regulator of hematopoietic lineage potential is suggested, and that trisomy of ERG in the context of DS foetal liver hemopoiesis drives the pre-leukemic changes that predispose to subsequent DS-TMD and DS-AMKL.
Journal ArticleDOI
PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia.
Helen M. McRae,Helen M. McRae,Alexandra L. Garnham,Alexandra L. Garnham,Yifang Hu,Matthew T. Witkowski,Matthew T. Witkowski,Mark A. Corbett,Mathew P. Dixon,Rose E. May,Bilal N. Sheikh,Bilal N. Sheikh,William Chiang,William Chiang,Andrew J. Kueh,Andrew J. Kueh,Tan A. Nguyen,Tan A. Nguyen,Kevin Man,Kevin Man,Renee Gloury,Brandon J. Aubrey,Brandon J. Aubrey,Antonia N. Policheni,Antonia N. Policheni,Ladina Di Rago,Warren S. Alexander,Warren S. Alexander,Daniel H.D. Gray,Daniel H.D. Gray,Andreas Strasser,Andreas Strasser,Edwin D. Hawkins,Edwin D. Hawkins,Stephen Wilcox,Stephen Wilcox,Jozef Gecz,Axel Kallies,Axel Kallies,Matthew P. McCormack,Gordon K. Smyth,Gordon K. Smyth,Anne K. Voss,Anne K. Voss,Tim Thomas,Tim Thomas +45 more
TL;DR: The data suggest that PHF6 is a hematopoietic tumor suppressor and is important for fine-tuning hematopolietic stem and progenitor cell homeostasis.