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Yonas Bekele
Researcher at Karolinska Institutet
Publications - 23
Citations - 388
Yonas Bekele is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Tuberculosis & Immune system. The author has an hindex of 11, co-authored 23 publications receiving 293 citations. Previous affiliations of Yonas Bekele include College of Health Sciences, Bahrain.
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Journal ArticleDOI
T-cell regulation in lepromatous leprosy.
Kidist Bobosha,Louis Wilson,Krista E. van Meijgaarden,Yonas Bekele,Martha Zewdie,Jolien J. van der Ploeg-van Schip,Markos Abebe,Jemal Hussein,Saraswoti Khadge,Kapil D. Neupane,Deanna A. Hagge,Ekaterina S. Jordanova,Abraham Aseffa,Tom H. M. Ottenhoff,Annemieke Geluk +14 more
TL;DR: Data show that CD25+ Treg cells play a role in M. leprae-Th1 unresponsiveness in LL, and furthermore, cell subset analysis showed significantly higher numbers of FoxP3+ CD8+CD 25+ T-cells in LL compared to BT patients, whereas confocal microscopy of skin biopsies revealed increased numbers of CD68+CD163+ as well as FoxP 3+ cells in lesions of LL.
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Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine Immunization
TL;DR: In this article, the identification of immune correlates of protection will facilitate the development of effective vaccines and therapeutics strategies, which will also contribute to lower risk of infection and amelioration of disease severity.
Journal ArticleDOI
Evaluation of cytokine responses against novel Mtb antigens as diagnostic markers for TB disease.
Dolapo Olaitan Awoniyi,Andrea Teuchert,Jayne S. Sutherland,Harriet Mayanja-Kizza,Rawleigh Howe,Adane Mihret,Andre G. Loxton,Jacob Sheehama,Desta Kassa,Amelia C. Crampin,Hazel M. Dockrell,Martin Kidd,Ida Rosenkrands,Annemieke Geluk,Tom H. M. Ottenhoff,P.L.A.M. Corstjens,Novel N. Chegou,Gerhard Walzl,Magdalena Kriel,Gian D. van der Spuy,Kim Stanley,Stephanus T. Malherbe,Shirley McAnda,Belinda Kriel,Khutso G. Phalane,Paulin N. Essone,Olumuyiwa Owolabi,Abdou K. Sillah,Joseph Mendy,Awa Gindeh,Simon Donkor,Toyin Togun,Martin O. C. Ota,Felanji Simukonda,Alemayehu Amberbir,Femia Chilongo,Rein M G J Houben,Atsbeha Gebrezgeabher,Getnet Mesfin,Yohannes Belay,Gebremedhin Gebremichael,Yodit Alemayehu,Marieta van der Vyver,Faustina N. Amutenya,Josefina N. Nelongo,Lidia Monye,Jacob Sheehama,Scholastica Iipinge,Ann Ritah Namuganga,Grace Muzanye,Mary Nsereko,Pierre Peters,Yonas Bekele,Bamlak Tessema,Lawrence Yamuah,Kees L. M. C. Franken,Paul L. A. M. Corstjens,Elisa M. Tjon Kon Fat,Claudia J. de Dood,Jolien J. van der Ploeg-van Schip,Claus Aagaard,Stefan H. E. Kaufmann,Maria M. Esterhuyse,Jacqueline M. Cliff +63 more
TL;DR: A biosignature of 6 cytokines obtained after stimulation with four Mtb antigens has moderate potential as a diagnostic tool for pulmonary TB disease individuals and stimulated marker expression had no added value to unstimulated marker performance.
Journal ArticleDOI
Prevalence of Disability and Associated Factors among Registered Leprosy Patients in All Africa Tb and Leprosy Rehabilitation and Training Centre (ALERT), Addis Ababa, Ethiopia.
TL;DR: Assessing leprosy disability status in patients registered at All African TB and Leprosy Rehabilitation and Training Centre found disability was associated with age, duration of symptom, sensory loss, signs of nerve damage and reversal reaction, which indicate the existence of delay in diagnosis and treatment of leproSy cases.
Journal ArticleDOI
Dysfunctional phenotypes of CD4+ and CD8+ T cells are comparable in patients initiating ART during early or chronic HIV-1 infection.
Sylvie Amu,Rebecka Lantto Graham,Yonas Bekele,Aikaterini Nasi,Carina Bengtsson,Bence Rethi,Sam Sorial,Genny Meini,Maurizio Zazzi,Bo Hejdeman,Francesca Chiodi +10 more
TL;DR: It is suggested that some abnormalities taking place in the T-cell compartment during primary HIV-1 infection may not be corrected by early ART, as shown in the results of this cross-sectional study.