J
Jer Yen Yang
Researcher at Purdue University
Publications - 47
Citations - 6599
Jer Yen Yang is an academic researcher from Purdue University. The author has contributed to research in topics: Cancer & Carcinogenesis. The author has an hindex of 32, co-authored 46 publications receiving 6100 citations. Previous affiliations of Jer Yen Yang include National Taiwan Ocean University & University of Texas at Austin.
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Journal ArticleDOI
IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a
Mickey C.T. Hu,Dung Fang Lee,Weiya Xia,Leonard Golfman,Fu Ou-Yang,Jer Yen Yang,Yiyu Zou,Shilai Bao,Norihisa Hanada,Hitomi Saso,Ryuji Kobayashi,Mien Chie Hung +11 more
TL;DR: Evidence is provided for the negative regulation of FOXO factors by IKK as a key mechanism for promoting cell growth and tumorigenesis by showing that IkappaB kinase physically interacts with, phosphorylates, and inhibits FOXO3a independent of Akt and causes proteolysis of FOXo3a via the Ub-dependent proteasome pathway.
Journal ArticleDOI
p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs
Chun Ju Chang,Chi-Hong Chao,Weiya Xia,Jer Yen Yang,Jer Yen Yang,Yan Xiong,Chia Wei Li,Wen Hsuan Yu,Sumaiyah K. Rehman,Jennifer L. Hsu,Heng Huan Lee,Mo Liu,Chun Te Chen,Dihua Yu,Mien Chie Hung +14 more
TL;DR: This study elucidates a role for p53 in regulating EMT–MET (mesenchymal–epithelial transition) and stemness or differentiation plasticity, and reveals a potential therapeutic implication to suppress EMT-associated cancer stem cells through activation of the p53–miR-200c pathway.
Journal ArticleDOI
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
Jer Yen Yang,Cong S. Zong,Weiya Xia,Hirohito Yamaguchi,Qingqing Ding,Xiaoming Xie,Jingyu Lang,Chien-Chen Lai,Chun Ju Chang,Wei Chien Huang,Hsin Huang,Hsu-Ping Kuo,Hsu-Ping Kuo,Dung Fang Lee,Dung Fang Lee,Long Yuan Li,Long Yuan Li,Huang-Chun Lien,Xiaoyun Cheng,Xiaoyun Cheng,King-Jen Chang,Chwan-Deng Hsiao,Fuu Jen Tsai,Chang Hai Tsai,Chang Hai Tsai,Aysegul A. Sahin,William J. Muller,Gordon B. Mills,Dihua Yu,Gabriel N. Hortobagyi,Mien Chie Hung +30 more
TL;DR: This study elucidates a novel pathway in cell growth and tumorigenesis through negative regulation of FOXO3a by RAS–ERK and MDM2 and downregulates Forkhead box O 3a by directly interacting with and phosphorylating FOXO 3a at Ser 294, Ser 344 and Ser 425.
Journal ArticleDOI
IKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mTOR Pathway
Dung Fang Lee,Hsu Ping Kuo,Hsu Ping Kuo,Chun Te Chen,Chun Te Chen,Jung Mao Hsu,Jung Mao Hsu,Chao Kai Chou,Chao Kai Chou,Yongkun Wei,Hui-Lung Sun,Long Yuan Li,Long Yuan Li,Long Yuan Li,Bo Ping,Wei Chien Huang,Xianghuo He,Jen Yu Hung,Chien-Chen Lai,Qingqing Ding,Jen Liang Su,Jer Yen Yang,Jer Yen Yang,Aysegul A. Sahin,Gabriel N. Hortobagyi,Fuu Jen Tsai,Chang Hai Tsai,Chang Hai Tsai,Mien Chie Hung +28 more
TL;DR: It is shown that IKKbeta, a major downstream kinase in the TNFalpha signaling pathway, physically interacts with and phosphorylates TSC1 at Ser487 and Ser511, resulting in suppression of T SC1 and activates the mTOR pathway, enhances angiogenesis, and results in tumor development.
Journal ArticleDOI
Erk Associates with and Primes GSK-3β for Its Inactivation Resulting in Upregulation of β-Catenin
Qingqing Ding,Weiya Xia,Jaw Ching Liu,Jer Yen Yang,Jer Yen Yang,Dung Fang Lee,Dung Fang Lee,Jiahong Xia,Geoffrey Bartholomeusz,Yan Li,Yong Pan,Zheng Li,Ralf C. Bargou,Jun Qin,Chien-Chen Lai,Fuu Jen Tsai,Chang Hai Tsai,Mien Chie Hung,Mien Chie Hung +18 more
TL;DR: A mechanism by which HBV-X protein (HBX) upregulates beta-catenin through a docking motif of GSK-3beta is reported, which is supported by immunohistochemical staining in different human tumors, including cancers of the liver, breast, kidney, and stomach.