Y
Yoshio Tsuboi
Researcher at Fukuoka University
Publications - 343
Citations - 9770
Yoshio Tsuboi is an academic researcher from Fukuoka University. The author has contributed to research in topics: Medicine & Parkinsonism. The author has an hindex of 44, co-authored 306 publications receiving 8018 citations. Previous affiliations of Yoshio Tsuboi include Brown University & Chiba University.
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Journal ArticleDOI
The metric properties of a novel non-motor symptoms scale for Parkinson's disease: Results from an international pilot study.
Kallol Ray Chaudhuri,Pablo Martinez-Martin,Richard G. Brown,Kapil D. Sethi,Fabrizio Stocchi,Per Odin,William G. Ondo,Kazuo Abe,Graeme Macphee,Doug MacMahon,Paolo Barone,Martin Rabey,A Forbes,Kieran Breen,S. Tluk,Y. Naidu,Warren Olanow,Adrian J. Williams,Sue Thomas,David B. Rye,Yoshio Tsuboi,Annette Hand,Anthony H.V. Schapira,Anthony H.V. Schapira +23 more
TL;DR: NMSS can be used to assess the frequency and severity of NMS in PD patients across all stages in conjunction with the recently validated non‐motor questionnaire.
Journal ArticleDOI
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation
Leonard Petrucelli,Dennis W. Dickson,Kathryn Kehoe,Julie P. Taylor,Heather Snyder,Andrew Grover,Michael De Lucia,Eileen McGowan,Jada Lewis,G. Prihar,Jungsu Kim,Wolfgang H. Dillmann,Susan E. Browne,Alexis Hall,Richard Voellmy,Yoshio Tsuboi,Ted M. Dawson,Benjamin Wolozin,John Hardy,Mike Hutton +19 more
TL;DR: It is reported that CHIP, an ubiquitin ligase that interacts directly with Hsp70/90, induces ubiquitination of the microtubule associated protein, tau, and that diverse of tau lesions in human postmortem tissue were found to be immunopositive for CHIP.
Journal ArticleDOI
Prevalence of nonmotor symptoms in Parkinson's disease in an international setting; Study using nonmotor symptoms questionnaire in 545 patients
Pablo Martinez-Martin,Anthony H.V. Schapira,Fabrizio Stocchi,Kapil D. Sethi,Per Odin,Graeme Macphee,Richard G. Brown,Y. Naidu,Lisa Clayton,Kazuo Abe,Yoshio Tsuboi,Dough MacMahon,Paolo Barone,Martin Rabey,Ubaldo Bonuccelli,A Forbes,Kieran Breen,S. Tluk,C. Warren Olanow,Sue Thomas,David B. Rye,Annette Hand,Adrian J. Williams,William G. Ondo,K. Ray Chaudhuri +24 more
TL;DR: The results gathered from 545 patients using the definitive version of the NMSQuest are presented highlighting the prevalence of the wide range of NMS flagged in the N MSQuest from consecutive PD patients in an international setting.
Journal ArticleDOI
Long-read sequencing identifies GGC repeat expansions in NOTCH2NLC associated with neuronal intranuclear inclusion disease.
Jun Sone,Satomi Mitsuhashi,Atsushi Fujita,Takeshi Mizuguchi,Kohei Hamanaka,Keiko Mori,Haruki Koike,Akihiro Hashiguchi,Hiroshi Takashima,Hiroshi Sugiyama,Yutaka Kohno,Yoshihisa Takiyama,Kengo Maeda,Hiroshi Doi,Shigeru Koyano,Hideyuki Takeuchi,Michi Kawamoto,Nobuo Kohara,Tetsuo Ando,Toshiaki Ieda,Yasushi Kita,Norito Kokubun,Yoshio Tsuboi,Kazutaka Katoh,Yoshihiro Kino,Masahisa Katsuno,Yasushi Iwasaki,Mari Yoshida,Fumiaki Tanaka,Ikuo K. Suzuki,Martin C. Frith,Naomichi Matsumoto,Gen Sobue,Gen Sobue +33 more
TL;DR: Long-read sequencing identifies a GGC repeat expansion in NOTCH2NLC that is associated with neuronal intranuclear inclusion disease, a progressive neurodegenerative disorder, and results in abnormal anti-sense transcripts that could contribute to disease pathogenesis.
Journal ArticleDOI
Neuropathology of variants of progressive supranuclear palsy.
TL;DR: Clinical variants in PSP reflect varying anatomical distribution of tau pathology, but they share histopathologic, biochemical and genetic features with typical PSP, which highlights the range of clinical and pathologic presentations of PSP and its variants.