Y
Yu Long Han
Researcher at Massachusetts Institute of Technology
Publications - 49
Citations - 2397
Yu Long Han is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 21, co-authored 38 publications receiving 1710 citations. Previous affiliations of Yu Long Han include Xi'an Jiaotong University & Harvard University.
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Journal ArticleDOI
Cell volume change through water efflux impacts cell stiffness and stem cell fate.
Ming Guo,Adrian F. Pegoraro,Angelo S. Mao,Enhua H. Zhou,Praveen R. Arany,Yu Long Han,Yu Long Han,Dylan T. Burnette,Mikkel H. Jensen,Mikkel H. Jensen,Karen E. Kasza,Karen E. Kasza,Jeffrey R. Moore,Fred C. MacKintosh,Fred C. MacKintosh,Jeffrey J. Fredberg,David J. Mooney,Jennifer Lippincott-Schwartz,David A. Weitz +18 more
TL;DR: A robust and unified relationship between cell stiffness and cell volume is identified and it is found that changes in cell volume, and hence stiffness, alter stem-cell differentiation, regardless of the method by which these are induced.
Journal ArticleDOI
Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition
Jan A. Burger,Dan A. Landau,Amaro Taylor-Weiner,Ivana Bozic,Huidan Zhang,Huidan Zhang,Huidan Zhang,Kristopher A. Sarosiek,Lili Wang,Chip Stewart,Jean Fan,Julia Hoellenriegel,Mariela Sivina,Adrian M. Dubuc,Cameron Fraser,Yu Long Han,Shuqiang Li,Kenneth J. Livak,Lihua Zou,Youzhong Wan,Sergej Konoplev,Carrie Sougnez,Jennifer R. Brown,Lynne V. Abruzzo,Scott L. Carter,Michael J. Keating,Matthew S. Davids,William G. Wierda,Kristian Cibulskis,Thorsten Zenz,Lillian Werner,Paola Dal Cin,Peter Kharchencko,Donna Neuberg,Hagop M. Kantarjian,Eric S. Lander,Stacey Gabriel,Susan O'Brien,Anthony Letai,David A. Weitz,Martin A. Nowak,Gad Getz,Catherine J. Wu,Catherine J. Wu,Catherine J. Wu +44 more
TL;DR: It is demonstrated that the ibrutinib therapy favours selection and expansion of rare subclones already present before ibrUTinib treatment, and insight is provided into the heterogeneity of genetic changes associated with ibrutsinib resistance.
Journal ArticleDOI
Cell contraction induces long-ranged stress stiffening in the extracellular matrix
Yu Long Han,Pierre Ronceray,Guoqiang Xu,Andrea Malandrino,Roger D. Kamm,Martin Lenz,Chase P. Broedersz,Ming Guo +7 more
TL;DR: In this article, the authors show that living contractile cells are able to generate a massive stiffness gradient in three distinct 3D extracellular matrix model systems: collagen, fibrin, and Matrigel.
Journal ArticleDOI
Engineering three-dimensional cell mechanical microenvironment with hydrogels
Guoyou Huang,Lin Wang,ShuQi Wang,Yu Long Han,Jinhui Wu,Qian-Cheng Zhang,Feng Xu,Tian Jian Lu +7 more
TL;DR: An overview of recent advances in engineering hydrogel-based 3D CMM is provided and effects of mechanical cues and externally induced stress/strain in hydrogels on cell behaviors are described.
Journal ArticleDOI
Oligonucleotide-linked gold nanoparticle aggregates for enhanced sensitivity in lateral flow assays
TL;DR: A simple and general one-step signal amplification strategy, which employed oligonucleotide-linked gold nanoparticle (AuNP) aggregates to enhance the sensitivity in nucleic acid lateral flow (NALF) assays.