Hong Ouyang

TL;DR: The results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate that applying the approach systematically to detect new loci requires extremely large sample sizes.

TL;DR: It is reported that repression of a single RNA binding polypyrimidine-tract-binding protein is sufficient to induce trans-differentiation of fibroblasts into functional neurons and has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure.

TL;DR: An essential role of the Hippo-YAP pathway in Gq/11-induced tumorigenesis is revealed and YAP is suggested as a potential drug target for UM patients carrying mutations in GNAQ or GNA11.

TL;DR: In this paper, the authors identify two distinct homozygous LSS missense mutations (W581R and G588S) in two families with extensive congenital cataracts.

TL;DR: This study demonstrates the critical role of caspase-8 in IOP-induced cell death in rodent models of acute glaucoma and identifies a mechanism of retinal retinal ganglion cell death and provides a previously unidentified treatment strategy to preserve vision in acute glAUcoma.