Yugo Tsuchiya

TL;DR: Changes in RNA and protein expression levels of CoA synthase, as well as CoA amount, are demonstrated in fibroblasts derived from the two clinical cases and in yeast, demonstrating the second inborn error of coenzyme A biosynthesis to be implicated in NBIA.

TL;DR: It is shown that protein CoAlation is a reversible post-translational modification that is induced in mammalian cells and tissues by oxidising agents and metabolic stress and may play an important role in redox regulation under physiological and pathophysiological conditions.

TL;DR: These findings suggest that in exponentially growing bacteria, CoA functions to generate metabolically active thioesters, while it also has the potential to act as a low-molecular-weight antioxidant in response to oxidative and metabolic stress.

TL;DR: The present mini-review describes the current understanding of the CoA biosynthetic pathway, provides a detailed overview on expression and subcellular localization of enzymes implicated in coA biosynthesis, their regulation and the potential to form multi-enzyme complexes for efficient and highly co-ordinated biosynthesis process.

TL;DR: In this article, the Fmo5−/− mice exhibit a lean phenotype, which is age-related, becoming apparent after 20 weeks of age, and the rate of fatty acid oxidation is higher in white adipose tissue (WAT), which would contribute to depletion of lipid stores in this tissue.