Jieyi Xiong

TL;DR: Across lifespan, splicing changes followed discrete patterns that could be linked to neural functions, and associated with the expression profiles of the corresponding splicing factors, and were abundant in both of the brain regions studied.

TL;DR: Deep epigenomes comprising genome-wide profiles of DNA methylation, histone modifications, DNA accessibility, and coding and non-coding RNA expression in naive, central-, effector-, and terminally differentiated Tmem cells from blood and bone marrow were generated and candidate master regulators of Tmem cell differentiation were identified.

TL;DR: A large-scale mass spectrometry-based analysis of the lipid composition of three brain regions as well as kidney and skeletal muscle of humans, chimpanzees, rhesus macaques, and mice provides the first insights into the role of lipids in human brain evolution.

TL;DR: A novel segmentation-based method, TEPIC, is reported to predict TF binding by combining sets of OCRs with position weight matrices, and finds low affinity binding sites to improve the ability to explain gene expression variability compared to the standard presence/absence classification of binding sites.

TL;DR: Accelerated evolution of the human brain and muscle metabolomes reflects the authors' unique cognitive and physical capacities.