P
Pavel V. Mazin
Researcher at Skolkovo Institute of Science and Technology
Publications - 25
Citations - 1094
Pavel V. Mazin is an academic researcher from Skolkovo Institute of Science and Technology. The author has contributed to research in topics: Alternative splicing & Gene. The author has an hindex of 11, co-authored 24 publications receiving 659 citations. Previous affiliations of Pavel V. Mazin include CAS-MPG Partner Institute for Computational Biology & Moscow State University.
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Journal ArticleDOI
Gene expression across mammalian organ development
Margarida Cardoso-Moreira,Margarida Cardoso-Moreira,Jean Halbert,Delphine Valloton,Britta Velten,C. T. Chen,Yi Shao,Angélica Liechti,Kelly Ascencao,Coralie Rummel,Svetlana Ovchinnikova,Pavel V. Mazin,Pavel V. Mazin,Ioannis Xenarios,Keith Harshman,Matthew Mort,David Neil Cooper,Carmen Sandi,Michael J. Soares,Michael J. Soares,Paula G. Ferreira,Sandra Afonso,Miguel Carneiro,James M. A. Turner,John L. VandeBerg,Amir Fallahshahroudi,Per Jensen,R. Behr,Steven Lisgo,Susan Lindsay,Philipp Khaitovich,Philipp Khaitovich,Philipp Khaitovich,Wolfgang Huber,Julie C. Baker,Simon Anders,Yong Zhang,Henrik Kaessmann +37 more
TL;DR: It is found that the breadth of gene expression and the extent of purifying selection gradually decrease during development, whereas the amount of positive selection and expression of new genes increase during development.
Journal ArticleDOI
Widespread splicing changes in human brain development and aging
Pavel V. Mazin,Pavel V. Mazin,Jieyi Xiong,Xiling Liu,Zheng Yan,Xiaoyu Zhang,Xiaoyu Zhang,Mingshuang Li,Mingshuang Li,Liu He,Mehmet Somel,Mehmet Somel,Yuan Yuan,Yuan Yuan,Yi-Ping Phoebe Chen,Na Li,Yuhui Hu,Ning Fu,Zhibin Ning,Rong Zeng,Hongyi Yang,Wei Chen,Wei Chen,Mikhail S. Gelfand,Philipp Khaitovich,Philipp Khaitovich +25 more
TL;DR: Across lifespan, splicing changes followed discrete patterns that could be linked to neural functions, and associated with the expression profiles of the corresponding splicing factors, and were abundant in both of the brain regions studied.
Journal ArticleDOI
Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains.
Ekaterina Khrameeva,Ilia Kurochkin,Dingding Han,Patricia Guijarro,Sabina Kanton,Malgorzata Santel,Zhengzong Qian,Shen Rong,Pavel V. Mazin,Pavel V. Mazin,Marat Sabirov,Matvei Bulat,Olga Efimova,Anna Tkachev,Anna Tkachev,Song Guo,Song Guo,Chet C. Sherwood,J. Gray Camp,Svante Pääbo,Barbara Treutlein,Philipp Khaitovich +21 more
TL;DR: Comparison of the bulk tissue and single nuclei sequencing revealed that conventional RNA sequencing did not detect up to two-thirds of cell-type-specific evolutionary differences in the human evolutionary lineage.
Journal ArticleDOI
LINC00116 codes for a mitochondrial peptide linking respiration and lipid metabolism.
Anastasia A. Chugunova,Anastasia A. Chugunova,Elizaveta Loseva,Pavel V. Mazin,Pavel V. Mazin,Aleksandra Mitina,Tsimafei I. Navalayeu,Dmitry S. Bilan,Polina Vishnyakova,M. V. Marey,Anna Y. Golovina,Marina V. Serebryakova,Marina V. Serebryakova,P. I. Pletnev,P. I. Pletnev,M. P. Rubtsova,M. P. Rubtsova,Waltraud Mair,Anna Vanyushkina,Philipp Khaitovich,Vsevolod V. Belousov,Vsevolod V. Belousov,Mikhail Vysokikh,Petr V. Sergiev,Petr V. Sergiev,Olga A. Dontsova,Olga A. Dontsova +26 more
TL;DR: Study of Mtln illuminates the importance of small peptides, whose genes might frequently be misannotated as long noncoding RNA (lncRNAs) for the control of vitally important cellular processes.
Journal ArticleDOI
Alternative splicing during mammalian organ development.
TL;DR: In this article, the authors assessed AS patterns across pre-and postnatal development of seven organs in six mammals and a bird and found that developmentally dynamic AS events, which are especially prevalent in the brain, are substantially more conserved than nondynamic ones.