Z
Zachary M. Earley
Researcher at Loyola University Chicago
Publications - 10
Citations - 3168
Zachary M. Earley is an academic researcher from Loyola University Chicago. The author has contributed to research in topics: Burn injury & Immune system. The author has an hindex of 6, co-authored 8 publications receiving 2228 citations. Previous affiliations of Zachary M. Earley include University of Chicago.
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Journal ArticleDOI
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy
Ayelet Sivan,Leticia Corrales,Nathaniel Hubert,Jason B. Williams,Keston Aquino-Michaels,Zachary M. Earley,Franco W. Benyamin,Yuk Man Lei,Bana Jabri,Maria-Luisa Alegre,Eugene B. Chang,Thomas F. Gajewski +11 more
TL;DR: Comparison of melanoma growth in mice harboring distinct commensal microbiota and observed differences in spontaneous antitumor immunity, suggests that manipulating the microbiota may modulate cancer immunotherapy.
Journal ArticleDOI
Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.
Marlies Meisel,Reinhard Hinterleitner,Alain Pacis,Li Chen,Zachary M. Earley,Toufic Mayassi,Joseph F. Pierre,Joseph F. Pierre,Jordan D. Ernest,Heather J. Galipeau,Nikolaus Thuille,Romain Bouziat,Manuel Buscarlet,Daina L. Ringus,Yitang Wang,Ye Li,Vu Dinh,Sangman M. Kim,Benjamin D. McDonald,Matthew A. Zurenski,Mark W. Musch,Glaucia C. Furtado,Sergio A. Lira,Gottfried Baier,Eugene B. Chang,A. Murat Eren,A. Murat Eren,Christopher R. Weber,Lambert Busque,Lucy A. Godley,Elena F. Verdu,Luis B. Barreiro,Bana Jabri +32 more
TL;DR: It is shown that bacterial translocation and increased interleukin-6 production, resulting from dysfunction of the small-intestinal barrier, are critical for the development of PMP in mice that lack Tet2 expression in haematopoietic cells.
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Burn Injury Alters the Intestinal Microbiome and Increases Gut Permeability and Bacterial Translocation.
Zachary M. Earley,Suhail Akhtar,Stefan J. Green,Ankur Naqib,Omair M. Khan,Abigail R. Cannon,Adam M. Hammer,Niya L. Morris,Xiaoling Li,Joshua M. Eberhardt,Richard L. Gamelli,Richard H. Kennedy,Mashkoor A. Choudhry +12 more
TL;DR: It is shown that burn injury induces a dramatic dysbiosis of the intestinal microbiome of both humans and mice and allows for similar overgrowths of Gram-negative aerobic bacteria, and that the bacteria increasing in abundance have the potential to translocate to extra-intestinal sites.
Journal ArticleDOI
Strain competition restricts colonization of an enteric pathogen and prevents colitis
Aaron L. Hecht,Benjamin W. Casterline,Zachary M. Earley,Young Ah Goo,David R. Goodlett,Juliane Bubeck Wardenburg +5 more
TL;DR: A novel role of type VI secretion systems in colonization resistance against a pathogen is demonstrated and this understanding of bacterial competition may be utilized to define a molecularly targeted probiotic strategy.
The First Line of Defense: The Effects of Alcohol on Post-Burn Intestinal Barrier, Immune Cells, and Microbiome.
TL;DR: The role of alcohol-mediated alterations of the intestinal epithelia and its defense against bacteria within the gut, and the impact of alcohol on intestinal immunity, specifically on T cells and neutrophils are highlighted.