Zhao Wang

TL;DR: In this article, the authors present expert opinions derived from an interdisciplinary working group on adult HLH, sponsored by the Histiocyte Society, to facilitate knowledge transfer between physicians caring for pediatric and adult patients with HLH with the aim to improve the outcome for adult patients affected by HLH.

TL;DR: This work identified somatic gene mutations in 25 people with NKTCL by whole-exome sequencing and confirmed them in an extended validation group of 80 people by targeted sequencing, contributing to the understanding of the disease mechanism ofNKTCL.

TL;DR: Recommendations address all main elements of HLH-94 including corticosteroids, cyclosporin, etoposide, intrathecal therapy, and hematopoietic stem cell transplantation (HSCT) and consider various forms of HLh and all age groups.

TL;DR: CPT was well tolerated up to 15mg/kg with promising efficacy in patients with Ral/Ref MM, and the optimal dose may be between 8.0 and 15.0 mg/kg/day, according to a phase Ib, multiple-center, open-label, single/multiple dose-escalation study.

TL;DR: Ongoing efforts to standardize safe and effective treatment protocols would improve the poor overall survival of m-PTLD, and ECOG PS, Ann Arbor stage, and CD68 IHC expression were independent prognostic factors for OS.