Jing Lu

TL;DR: Clinical data from 326 cases suggest that T cell depletion and cytokine bursts are associated with a worse prognosis, and genomic sequences from 112 patients with confirmed SARS-CoV-2 virus showed two clades with similar virulence and clinical outcome.

TL;DR: This work identified somatic gene mutations in 25 people with NKTCL by whole-exome sequencing and confirmed them in an extended validation group of 80 people by targeted sequencing, contributing to the understanding of the disease mechanism ofNKTCL.

TL;DR: The genomic landscape in 130 patients, including 61 cases of adult T-ALL, was addressed, with thirty-six distinct gene fusion transcripts identified, with SET-NUP214 being highly related to adult cases and ZBTB16-ABL1, TRA-SALL2, and involvement of NKX2-1 were recurrent events.

TL;DR: In this paper, the authors performed whole-genome sequencing in CD34+ hematopoietic stem/progenitor cells (HSPCs) from eight cases of refractory anemia with excess blasts (RAEB), the high-risk subtype of MDS.

TL;DR: It is shown that Dnmt3a R878H is sufficient to initiate AML and recapitulate human leukemic features in mice by using a conditional knockin approach and revealed the potential therapeutic effects of mTOR inhibition on DNMT3A mutation-related leukemia.