Journal ArticleDOI
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma
Lu Jiang,Zhaohui Gu,Zi-Xun Yan,Xia Zhao,Yin-Yin Xie,Zi-Guan Zhang,Chun-Ming Pan,Yuan Hu,Chang-Ping Cai,Ying Dong,Jinyan Huang,Li Wang,Yang Shen,Guoyu Meng,Jianfeng Zhou,Jianda Hu,Jin-Fen Wang,Yuan-Hua Liu,Lin-Hua Yang,Feng Zhang,Jianmin Wang,Zhao Wang,Zhigang Peng,Fang-Yuan Chen,Zi-Min Sun,Hao Ding,Jumei Shi,Jian Hou,Jin-Song Yan,Jing-Yi Shi,Lan Xu,Yang Li,Jing Lu,Zhong Zheng,Wen Xue,Wei-Li Zhao,Zhu Chen,Sai-Juan Chen +37 more
TLDR
This work identified somatic gene mutations in 25 people with NKTCL by whole-exome sequencing and confirmed them in an extended validation group of 80 people by targeted sequencing, contributing to the understanding of the disease mechanism ofNKTCL.Abstract:
Zhu Chen, Sai-Juan Chen, Wei-Li Zhao and colleagues identify recurrent loss-of-function mutations in the RNA helicase gene DDX3X in 20% of subjects with natural killer/T-cell lymphoma (NKTCL) in their study. The results suggest that DDX3X acts as a tumor suppressor and that its inactivation leads to poor clinical outcome.read more
Citations
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Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations
Raphael Bueno,Eric Stawiski,Leonard D. Goldstein,Steffen Durinck,Assunta De Rienzo,Zora Modrusan,Florian Gnad,Thong T. Nguyen,Bijay S. Jaiswal,Lucian R. Chirieac,Daniele Sciaranghella,Nhien Dao,Corinne E. Gustafson,Kiara J. Munir,Jason A. Hackney,Amitabha Chaudhuri,Ravi Gupta,Joseph Guillory,Karen Toy,Connie Ha,Ying-Jiun Chen,Jeremy Stinson,Subhra Chaudhuri,Na Zhang,Thomas D. Wu,David J. Sugarbaker,Frederic J. de Sauvage,William G. Richards,Somasekar Seshagiri +28 more
TL;DR: Recurrent gene fusions and splice alterations to be frequent mechanisms for inactivation of NF2, BAP1 and SETD2 are found and alterations in Hippo, mTOR, histone methylation, RNA helicase and p53 signaling pathways in MPMs are identified.
Journal ArticleDOI
Epstein–Barr virus-associated lymphomas
TL;DR: Recent developments in the understanding of EBV-associated lymphomagenesis in both the immunocompetent and Immunocompromised host are reviewed.
Journal ArticleDOI
Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias
Andrew Dunford,David M. Weinstock,David M. Weinstock,Virginia Savova,Steven E. Schumacher,Steven E. Schumacher,John P Cleary,Akinori Yoda,Timothy J. Sullivan,Julian M. Hess,Alexander A. Gimelbrant,Alexander A. Gimelbrant,Rameen Beroukhim,Rameen Beroukhim,Michael S. Lawrence,Gad Getz,Gad Getz,Andrew A. Lane,Andrew A. Lane +18 more
TL;DR: It is concluded that biallelic expression of EXITS genes in females explains a portion of the reduced cancer incidence in females as compared to males across a variety of tumor types.
Journal ArticleDOI
The Global Landscape of EBV-Associated Tumors.
TL;DR: The main characteristics of these tumors, their distinct epidemiologies, histological features and degrees of EBV association are described, then how their different patterns ofEBV latency may reflect the alternative latency programmes through which the virus first colonizes and then persists in immunocompetent host is considered.
Journal ArticleDOI
Sexual dimorphism in cancer.
TL;DR: This Opinion article focuses on the complex interplay that sex hormones and sex chromosomes can have in intrinsic control of cancer-initiating cell populations, the tumour microenvironment and systemic determinants of cancer development, such as the immune system and metabolism.
References
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The Sequence Alignment/Map format and SAMtools
Heng Li,Bob Handsaker,Alec Wysoker,T. J. Fennell,Jue Ruan,Nils Homer,Gabor T. Marth,Gonçalo R. Abecasis,Richard Durbin +8 more
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Ivan Adzhubei,Steffen Schmidt,Leonid Peshkin,Vasily Ramensky,Anna Gerasimova,Peer Bork,Alexey S. Kondrashov,Shamil R. Sunyaev +7 more
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Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Rafael A. Irizarry,Bridget G. Hobbs,Francois Collin,Yasmin Beazer-Barclay,Kristen J. Antonellis,Uwe Scherf,Terence P. Speed +6 more
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