Z
Zhengdong D. Zhang
Researcher at Albert Einstein College of Medicine
Publications - 84
Citations - 18056
Zhengdong D. Zhang is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Gene & Human genome. The author has an hindex of 36, co-authored 72 publications receiving 16777 citations. Previous affiliations of Zhengdong D. Zhang include Baylor College of Medicine & University of Houston.
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Journal ArticleDOI
Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human
Sheila L. MacRae,Quanwei Zhang,Christophe Lemetre,Inge Seim,Robert B. Calder,Jan H.J. Hoeijmakers,Yousin Suh,Vadim N. Gladyshev,Andrei Seluanov,Vera Gorbunova,Jan Vijg,Zhengdong D. Zhang +11 more
TL;DR: The data suggest that the long‐lived NMR, as well as human, has more robust GM than mouse and identifies new targets for the analysis of the exceptional longevity of the NMR.
Journal ArticleDOI
Enhancer release and retargeting activates disease-susceptibility genes.
Soohwan Oh,Jiaofang Shao,Joydeep Mitra,Feng Xiong,Matteo D’Antonio,Ruoyu Wang,Ruoyu Wang,Ivan Garcia-Bassets,Qi Ma,Xiaoyu Zhu,Joo-Hyung Lee,Sreejith J Nair,Feng Yang,Kenneth A. Ohgi,Kelly A. Frazer,Zhengdong D. Zhang,Wenbo Li,Wenbo Li,Michael G. Rosenfeld +18 more
TL;DR: In this paper, the authors show that functional loss of a preferred promoter can release its partner enhancer to loop to and activate an alternative promoter (or alternative promoters) in the neighbourhood.
Journal ArticleDOI
Translation fidelity coevolves with longevity.
Zhonghe Ke,Pramit Mallik,Adam B. Johnson,Facundo Luna,Eviatar Nevo,Zhengdong D. Zhang,Vadim N. Gladyshev,Andrei Seluanov,Vera Gorbunova +8 more
TL;DR: The relationship between translation fidelity and maximum lifespan and frequency of amino acid misincorporation at the first and second codon positions showed strong negative correlation with maximum lifespan, indicating that translation fidelity coevolves with longevity.
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The finished DNA sequence of human chromosome 12
Steven E. Scherer,Donna M. Muzny,Christian J. Buhay,Rui Chen,Andrew Cree,Yan Ding,Shannon Dugan-Rocha,Rachel Gill,Preethi H. Gunaratne,R. Alan Harris,Alicia Hawes,Judith Hernandez,Anne Hodgson,Jennifer Hume,Andrew R. Jackson,Ziad Khan,Christie Kovar-Smith,Lora Lewis,Ryan J. Lozado,Michael L. Metzker,Aleksandar Milosavljevic,George Miner,Kate Montgomery,Margaret Morgan,Lynne V. Nazareth,Graham R. Scott,Erica Sodergren,Xing Zhi Song,David Steffen,Ruth C. Lovering,David A. Wheeler,Kim C. Worley,Yi Yuan,Zhengdong D. Zhang,Charles Q. Adams,M. Ali Ansari-Lari,Mulu Ayele,Mary J. Brown,Guan Chen,Zhijian J. Chen,Kerstin P. Clerc-Blankenburg,Clay Davis,Oliver Delgado,Huyen Dinh,Heather R. Draper,Manuel L. Gonzalez-Garay,Paul Havlak,LaRonda Jackson,Leni S. Jacob,Susan H. Kelly,Li Li,Zhangwan Li,Jing Liu,Wen Liu,Jing Lu,Manjula Maheshwari,Bao Viet Nguyen,Geoffrey Okwuonu,Shiran Pasternak,Lesette Perez,Farah J.H. Plopper,Jireh Santibanez,Hua Shen,Paul E. Tabor,Daniel Verduzco,Lenee Waldron,Qiaoyan Wang,Gabrielle A. Williams,Jing Kun Zhang,Jianling Zhou,David L. Nelson,Raju Kucherlapati,George M. Weinstock,Richard A. Gibbs +73 more
TL;DR: Alignment of the human chromosome 12 sequence across vertebrates reveals the origin of individual segments in chicken, and a unique history of rearrangement through rodent and primate lineages.
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Tilescope: online analysis pipeline for high-density tiling microarray data
TL;DR: Tilescope is a fully integrated data processing pipeline for analyzing high-density tiling-array data, designed with a modular, three-tiered architecture, facilitating parallelism, and a graphic user-friendly interface.