F
Feng Xiong
Researcher at University of Texas Health Science Center at Houston
Publications - 12
Citations - 386
Feng Xiong is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Gene & Enhancer. The author has an hindex of 4, co-authored 9 publications receiving 109 citations. Previous affiliations of Feng Xiong include University of Texas MD Anderson Cancer Center & University of Texas Health Science Center at San Antonio.
Papers
More filters
Journal ArticleDOI
Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation.
Joo-Hyung Lee,Ruoyu Wang,Ruoyu Wang,Feng Xiong,Joanna Krakowiak,Zian Liao,Zian Liao,Phuoc T. Nguyen,Phuoc T. Nguyen,Elena V. Moroz-Omori,Jiaofang Shao,Xiaoyu Zhu,Michael J. Bolt,Haoyi Wu,Haoyi Wu,Pankaj Singh,Mingjun Bi,Caleb J. Shi,Naadir Jamal,Guojie Li,Ragini Mistry,Sung Yun Jung,Kuang-Lei Tsai,Josephine C. Ferreon,Fabio Stossi,Amedeo Caflisch,Zhijie Liu,Michael A. Mancini,Wenbo Li,Wenbo Li +29 more
TL;DR: In this article, a high sensitivity method methylation-inscribed nascent transcripts sequencing (MINT-seq) was used to characterize the landscapes of N6-methyladenosine (m6A) on nascent RNAs.
Journal ArticleDOI
AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate
Qilin Gu,Xiaojie Yang,Jie Lv,Jiaxiong Zhang,Jiaxiong Zhang,Bo Xia,Jun Dae Kim,Ruoyu Wang,Feng Xiong,Shu Meng,Thomas P. Clements,Bhavna Tandon,Daniel S. Wagner,Miguel F. Diaz,Pamela L. Wenzel,Yury I. Miller,David Traver,John P. Cooke,John P. Cooke,Wenbo Li,Leonard I. Zon,Kaifu Chen,Yongping Bai,Longhou Fang +23 more
TL;DR: It is reported that a somite-derived prohematopoietic cue, AIBP, orchestrates HSPC emergence from the hemogenic endothelium, a type of specialized endot Helium manifesting hematopoetic potential, and an AIBP-regulated Srebp2-dependent paradigm for HspC emergence in development and HPSC expansion in atherosclerotic cardiovascular disease is outlined.
Journal ArticleDOI
Enhancer RNAs in cancer: regulation, mechanisms and therapeutic potential
TL;DR: It is proposed that further studies of eRNAs in cancer will offer a promising ‘eRNA targeted therapy’ for human cancer intervention.
Journal ArticleDOI
Enhancer release and retargeting activates disease-susceptibility genes.
Soohwan Oh,Jiaofang Shao,Joydeep Mitra,Feng Xiong,Matteo D’Antonio,Ruoyu Wang,Ruoyu Wang,Ivan Garcia-Bassets,Qi Ma,Xiaoyu Zhu,Joo-Hyung Lee,Sreejith J Nair,Feng Yang,Kenneth A. Ohgi,Kelly A. Frazer,Zhengdong D. Zhang,Wenbo Li,Wenbo Li,Michael G. Rosenfeld +18 more
TL;DR: In this paper, the authors show that functional loss of a preferred promoter can release its partner enhancer to loop to and activate an alternative promoter (or alternative promoters) in the neighbourhood.
Journal ArticleDOI
The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis.
Tuan M. Nguyen,Elena B. Kabotyanski,Lucas C. Reineke,Jiaofang Shao,Feng Xiong,Joo-Hyung Lee,Julien Dubrulle,Hannah L. Johnson,Fabio Stossi,Phoebe S. Tsoi,Kyoung-Jae Choi,Alexander G. Ellis,Na Zhao,Jin Cao,Oluwatoyosi Adewunmi,Oluwatoyosi Adewunmi,Josephine C. Ferreon,Allan Chris M. Ferreon,Joel R. Neilson,Michael A. Mancini,Xi Chen,Jongchan Kim,Li Ma,Wenbo Li,Jeffrey M. Rosen +24 more
TL;DR: It is shown that Malat1 with a SINE deletion forms diffuse nuclear speckles and is frequently translocated to the cytoplasm, demonstrating the significance of lncRNA TEs in TDP-43 proteostasis with potential implications in both cancer and neurodegenerative diseases.