Z
Zihu Guo
Researcher at Northwest A&F University
Publications - 37
Citations - 3071
Zihu Guo is an academic researcher from Northwest A&F University. The author has contributed to research in topics: Systems pharmacology & Modern medicine. The author has an hindex of 12, co-authored 33 publications receiving 1617 citations. Previous affiliations of Zihu Guo include Beijing University of Chinese Medicine & Northwest University (China).
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Journal ArticleDOI
TCMSP: a database of systems pharmacology for drug discovery from herbal medicines.
Jinlong Ru,Peng Li,Wang Jinan,Wei Zhou,Bohui Li,Chao Huang,Pidong Li,Zihu Guo,Weiyang Tao,Yinfeng Yang,Xue Xu,Yan Li,Yonghua Wang,Ling Yang +13 more
TL;DR: The particular strengths of TCMSP are the composition of the large number of herbal entries, and the ability to identify drug-target networks and drug-disease networks, which will help revealing the mechanisms of action of Chinese herbs, uncovering the nature ofTCM theory and developing new herb-oriented drugs.
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Large-scale exploration and analysis of drug combinations
Peng Li,Chao Huang,Yingxue Fu,Wang Jinan,Ziyin Wu,Jinlong Ru,Chunli Zheng,Zihu Guo,Xuetong Chen,Wei Zhou,Wenjuan Zhang,Yan Li,Jianxin Chen,Aiping Lu,Yonghua Wang +14 more
TL;DR: A systems pharmacology framework to predict drug combinations (PreDCs) on a computational model, termed probability ensemble approach (PEA), for analysis of both the efficacy and adverse effects of drug combinations.
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Large-scale Direct Targeting for Drug Repositioning and Discovery
Chunli Zheng,Zihu Guo,Chao Huang,Ziyin Wu,Yan Li,Xuetong Chen,Yingxue Fu,Jinlong Ru,Piar Ali Shar,Yuan Wang,Yonghua Wang +10 more
TL;DR: A novel algorithm termed weighted ensemble similarity (WES) has been developed to identify drug direct targets based on a large-scale of 98,327 drug-target relationships and shows that the WES method provides a potential in silico model for drug repositioning and discovery.
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Systematic understanding the mechanisms of vitiligo pathogenesis and its treatment by Qubaibabuqi formula.
Tianli Pei,Chunli Zheng,Chao Huang,Xuetong Chen,Zihu Guo,Yingxue Fu,Jianling Liu,Yonghua Wang +7 more
TL;DR: The drug-target network- based analysis and pathway-based analysis can provide a new approach for understanding the pathogenesis of vitiligo and uncovering the molecular mechanisms of Qubaibabuqi, which will also facilitate the application of traditional Chinese herbs in modern medicine.
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Systems-Pharmacology Dissection of Traditional Chinese Medicine Compound Saffron Formula Reveals Multi-scale Treatment Strategy for Cardiovascular Diseases.
Jianling Liu,Jiexin Mu,Jiexin Mu,Chunli Zheng,Xuetong Chen,Zihu Guo,Chao Huang,Yingxue Fu,Guihua Tian,Hongcai Shang,Yonghua Wang +10 more
TL;DR: CSF has multi-scale curative activity in regulating CVD-related biological processes, which provides a new potential way for modern medicine in the treatment of complex diseases.