Chalmers University of Technology

About: Chalmers University of Technology is a education organization based out in Gothenburg, Sweden. It is known for research contribution in the topics: Catalysis & Finite element method. The organization has 17191 authors who have published 53951 publications receiving 1520592 citations. The organization is also known as: Chalmers Tekniska Högskola & Chalmers.

Metabolic Engineering of Saccharomyces cerevisiae: A Key Cell Factory Platform for Future Biorefineries

Abstract: Metabolic engineering is the enabling science of development of efficient cell factories for the production of fuels, chemicals, pharmaceuticals, and food ingredients through microbial fermentations. The yeast Saccharomyces cerevisiae is a key cell factory already used for the production of a wide range of industrial products, and here we review ongoing work, particularly in industry, on using this organism for the production of butanol, which can be used as biofuel, and isoprenoids, which can find a wide range of applications including as pharmaceuticals and as biodiesel. We also look into how engineering of yeast can lead to improved uptake of sugars that are present in biomass hydrolyzates, and hereby allow for utilization of biomass as feedstock in the production of fuels and chemicals employing S. cerevisiae. Finally, we discuss the perspectives of how technologies from systems biology and synthetic biology can be used to advance metabolic engineering of yeast.

A new generation of algorithms for computerized threshold perimetry, SITA

Abstract: PURPOSE: The purpose of this work was to develop a new family of test algorithms for computerized static threshold perimetry which significantly reduces test time without any reduction of data quality.METHODS: A comprehensive visual field model constructed from available knowledge of normal and glaucomatous visual fields is continuously updated during testing. The model produces threshold estimates and also estimates of the certainty to which the threshold is known at each point. Testing is interrupted at each test location at predetermined levels of threshold certainty. New time-saving methods are employed for estimation of false answers, and test pacing is optimized. After completion of the test, all threshold estimates are re-computed, taking into account the complete body of patient responses. Computer simulations were used to optimize the different parameters of the new algorithms, to evaluate the relative importance of those parameters, and to evaluate the performance of the algorithm as a whole in comparison with a standard algorithm.RESULTS: Simulated test results obtained with this algorithm were slightly more accurate than those of the Humphrey Full Threshold test algorithm. The number of simulated stimuli presented was reduced by an average of 29% in normal fields and 26% in glaucomatous fields. Actual clinical test time should be further reduced, since the influence of the improved timing algorithm was not included in the simulations.CONCLUSIONS: We applied new methods which take available knowledge of visual field physiology and pathophysiology into account, and employ modern computer-intensive mathematical methods for real time estimates of threshold values and threshold error estimates. In this way it was possible to design a family of testing algorithms which significantly reduced perimetric test time without any loss of quality in results. (Less)

A fast triangle-triangle intersection test

Abstract: This paper presents a method, along with some optimizations, for computing whether or not two triangles intersect. The code, which is shown to be fast, can be used, for example, in collision detection algorithms.

Aspect ratio and end plate effects on vortex shedding from a circular cylinder

Abstract: Aspect ratio effects on the vortex shedding flow from a circular cylinder have been studied by using moveable end plates. Experiments were carried out to measure fluctuating forces, shedding frequency and spanwise correlation whilst varying end plate separation and Reynolds number. The aspect ratio (0.25-12) was found to have a most striking effect on the fluctuating lift. Within a certain range of Reynolds number an increase of the sectional fluctuating lift was obtained for reduced aspect ratio, and showed a maximum for an aspect ratio of 1, where the fluctuating lift could be almost twice the value for very large aspect ratios. This increase of the lift amplitude was found to be accompanied by enhanced spanwise correlation of the flow. The measurements were carried out over the Reynolds number range 8 > 103 < Re < 1.4 x 105. The strong increase in fluctuating lift with small aspect ratio did not occur at the lower and upper boundaries of this range. In the lower Reynolds number range (Re < 2 x 104) the trend could be reversed, i.e. the fluctuating lift decreased with decreasing aspect ratio. Also, with small aspect ratio, a shedding breakdown was found in the upper Reynolds number range (Re = 1.3 x 105). The main three dimensional feature observed was a spanwise variation in the phase of vortex shedding, accompanied by amplitude modulation in the lift signal. However, the level of three-dimensionality can be reduced by using a small aspect ratio. Three-dimensional vortex shedding features are discussed and comparison of the results with those from both two-dimensional numerical simulations and other experiments using large aspect ratios are presented.