Clarkson University

About: Clarkson University is a education organization based out in Potsdam, New York, United States. It is known for research contribution in the topics: Particle & Turbulence. The organization has 4414 authors who have published 10009 publications receiving 305356 citations. The organization is also known as: Thomas S. Clarkson Memorial School of Technology & Thomas S. Clarkson Memorial College of Technology.

Investigation of stable and transient protein-protein interactions: Past, present, and future

Abstract: This article presents an overview of the literature and a review of recent advances in the analysis of stable and transient protein-protein interactions (PPIs) with a focus on their function within cells, organs, and organisms. The significance of PTMs within the PPIs is also discussed. We focus on methods to study PPIs and methods of detecting PPIs, with particular emphasis on electrophoresis-based and MS-based investigation of PPIs, including specific examples. The validation of PPIs is emphasized and the limitations of the current methods for studying stable and transient PPIs are discussed. Perspectives regarding PPIs, with focus on bioinformatics and transient PPIs are also provided.

Predicting Hot Spots of Herpetofauna Road Mortality Along Highway Networks

Abstract: Road mortality is often spatially aggregated, and there is a need for models that accurately and efficiently predict hot spots within a road network for mitigation. We surveyed 145 points throughout a 353-km highway network in New York State, USA, for roadkill of reptiles and amphibians. We used land cover, wetland configuration, and traffic volume data to identify features that best predicted hot spots of herpetofauna road mortality. We resampled 40 points an additional 4 times over 4 years to evaluate temporal repeatability. Both amphibian and reptile road mortality were spatially clustered, and road-kill hot spots of the 2 taxa overlapped. One survey provided a valid snapshot of spatial patterns of road mortality, and spatial patterns remained stable across time. Road-kill hot spots were located where wetlands approached within 100 m of the road, and the best predictor was a causeway configuration of wetlands (wetlands on both sides of the road). We validated causeways as predictors of road mortality by surveying 180 causeways and 180 random points across 5 regions (17,823 km2) of northeastern New York. Causeways were 3 times more likely than random locations to have amphibian and 12 times more likely to have reptile mortality present, and causeways had a 4 times higher total number of amphibian roadkill and 9 times higher reptile roadkill than did random points. We conclude it is possible to identify valid predictors of hot spots of amphibian and reptile road mortality for use when planning roads or when conducting surveys on existing roads to locate priority areas for mitigation.

Collaborative testing of eddy structure identification methods in free turbulent shear flows

Abstract: The thrust of this paper is to validate, test and compare several Coherent Structure eduction methods utilizing the same data base. The flow chosen was that of an experimental study of a plane, incompressible, fully developed turbulent two-stream mixing layer. The mixing layer was chosen as the data base because it has been studied extensively from a coherent structures point of view. In addition, its characteristics (similarity, convection velocities, etc.) are well documented. There are also no wall effects so that comparisons between techniques are simplified. The data was collected from hot wire rakes with good spatial resolution thus allowing the contributors to apply and test different structure eduction techniques. The techniques chosen for discussion and used here have found wide utilization over the past decade, and all hold forth the promise of extensive application in the future. These include: Conditional Sampling (Vorticity-based and other methods); Wavelets; Pattern Recognition Analysis; Proper Orthogonal Decomposition; Stochastic Estimation; Topological Concept-based methods; Full Field Methods (e.g., pseudo flow visualization). All are illustrated by application to the mixing layer data base, and comparisons made between the results. This common study has shown that direct comparisons between results of several methods are now possible. Good quantitive and qualitative agreement between the different methods have been observed as well as some differences noted. As an example, the size of the averaged structures computed from the various methods compare to within 6 percent.

COSMOSPACE: Alternative to conventional activity‐coefficient models

Abstract: An analytical solution, COSMOSPACE, to the statistical thermodynamics of a model of pairwise interacting surfaces, is presented. This solution was initially developed for the a priori prediction model COSMO-RS in an implicit form. A comparison of COSMOSPACE with UNIQUAC and with the quasi-chemical theory of Guggenheim reveals the conditions under which the models yield similar results and when they differ very considerably. It is shown that COSMOSPACE is in extremely good agreement with Monte-Carlo simulations for some lattice fluids (where UNIQUAC is particularly poor). The ability of COSMOSPACE to provide good fits to experimental data is shown for three binary mixtures including ethanol-cyclohexane, where UNIQUAC incorrectly predicts a liquid-liquid phase separation.