Clarkson University

About: Clarkson University is a education organization based out in Potsdam, New York, United States. It is known for research contribution in the topics: Particle & Turbulence. The organization has 4414 authors who have published 10009 publications receiving 305356 citations. The organization is also known as: Thomas S. Clarkson Memorial School of Technology & Thomas S. Clarkson Memorial College of Technology.

Optimization of Enzymatic Biochemical Logic for Noise Reduction and Scalability: How Many Biocomputing Gates Can Be Interconnected in a Circuit?

Abstract: We report an experimental evaluation of the "input-output surface" for a biochemical AND gate. The obtained data are modeled within the rate-equation approach, with the aim to map out the gate function and cast it in the language of logic variables appropriate for analysis of Boolean logic for scalability. In order to minimize "analog" noise, we consider a theoretical approach for determining an optimal set for the process parameters to minimize "analog" noise amplification for gate concatenation. We establish that under optimized conditions, presently studied biochemical gates can be concatenated for up to order 10 processing steps. Beyond that, new paradigms for avoiding noise build-up will have to be developed. We offer a general discussion of the ideas and possible future challenges for both experimental and theoretical research for advancing scalable biochemical computing.

Examination and treatment of a patient with hypermobility syndrome.

Abstract: Background and Purpose. The purpose of this case report is to present the examination, evaluation/diagnosis/prognosis, intervention, and outcome of a patient with hypermobility syndrome (HMS). Hypermobility syndrome has been widely recognized in the rheumatology literature, but it has seldom been discussed in the orthopedic literature and has only recently been described in the physical therapy literature. The signs and symptoms of HMS are common among patients seen in orthopedic physical therapy clinics; however, the HMS may be overlooked while treating individual joints or tissues causing pain. Case Description. The patient was a 28-year-old woman with complaints of chronic, multiple-joint pain. After years without a diagnosis, a rheumatologist had recently diagnosed her as having HMS. Outcomes. Following intervention that emphasized patient education and activity modification, the patient's complaints decreased. Discussion. Recognition of HMS underlying common orthopedic problems may facilitate appropriate patient education and management.

Simplified Physically Based Model of Earthen Embankment Breaching

Abstract: A simplified physically based model has been developed to simulate the breaching processes of homogenous and composite earthen embankments owing to overtopping and piping. The breach caused by overtopping flow is approximated as a flat broad-crested weir with a trapezoidal cross section, downstream connected with a vertical drop (headcut) and a straight slope for cohesive and noncohesive homogeneous embankments, respectively. For a composite dam with a clay core, the downstream becomes two straight slopes after the core is exposed. The breach by piping is assumed to be a flat pipe with rectangular cross section until the pipe top collapses and overtopping takes place. Sediment transport and morphology changes on the breach top flat section and downstream slopes and inside the pipe are calculated using a nonequilibrium total-load sediment transport model, whereas the time-averaged headcut migration rate is determined using an empirical formula. Stabilities of the side slope, pipe top, headcut, and ...