Institution
Dalian Medical University
Education•Dalian, China•
About: Dalian Medical University is a education organization based out in Dalian, China. It is known for research contribution in the topics: Cancer & Apoptosis. The organization has 15623 authors who have published 9993 publications receiving 164145 citations.
Topics: Cancer, Apoptosis, Cell growth, Metastasis, PI3K/AKT/mTOR pathway
Papers published on a yearly basis
Papers
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TL;DR: Increased scarring in fmod(-/-) mice indicates that TGF-β3's antimotility effects predominate over its antifibrotic effects when high TGF -β3 levels disrupt early fibroblastic wound ingress.
63 citations
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Chinese Ministry of Education1, Anhui Medical University2, Fourth Military Medical University3, China Medical University (PRC)4, Central South University5, Dalian Medical University6, Third Military Medical University7, Inner Mongolia Medical University8, Guangxi Medical University9, Peking University10, Fudan University11, University of British Columbia12, Icahn School of Medicine at Mount Sinai13
TL;DR: Findings provide indirect support that vitiligo pathogenesis involves a complex interplay between immune regulatory factors and melanocyte-specific factors and highlight similarities and differences in the genetic basis of vitiliga in Chinese and Caucasian populations.
63 citations
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TL;DR: MiR-140-5p and miR-149 could mediate the development of OA, which was regulated by FUT1, and might serve as a predictive biomarker and a potential therapeutic target in OA treatment.
Abstract: Osteoarthritis (OA), the most prevalent chronic and degenerative joint disease, is characterized by articular cartilage degradation and chondrocyte injury. Increased cell apoptosis and defective cell autophagy in chondrocytes are a feature of degenerative cartilage. MicroRNAs (miRNAs) have been identified as potential regulators of OA. This study aimed to determine the potential role of miR-140-5p and miR-149 in apoptosis, autophagy, and proliferation in human primary chondrocytes and investigate the underlying mechanism. We revealed the differential expressional profiles of miR-140-5p/149 and fucosyltransferase 1 (FUT1) in the articular cartilage tissues of OA patients and normal people and validated FUT1 was a direct target of miR-140-5p/149. The overexpression of miR-140-5p/149 inhibited apoptosis and promoted proliferation and autophagy of human primary chondrocytes via downregulating FUT1. On the contrary, the downregulation of miR-140-5p/149 inhibited chondrocyte proliferation and autophagy, whereas the effect was reversed by FUT1 knockdown. Taken together, our data suggested that miR-140-5p and miR-149 could mediate the development of OA, which was regulated by FUT1. miR-140-5p/miR-149/FUT1 axis might serve as a predictive biomarker and a potential therapeutic target in OA treatment.
63 citations
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TL;DR: AB23A produces protective effect against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes.
63 citations
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TL;DR: It is shown that repeat administration of bone marrow mononuclear cells can improve left ventricular function compared with a single infusion in patients with large acute myocardial infarction.
Abstract: Aims
We sought to determine whether repeat administration of bone marrow mononuclear cells (BMC) can improve left ventricular function compared with a single infusion in patients with large acute myocardial infarction (AMI).
Methods and results
Thirty-nine patients with a ST-elevation AMI of the anterior wall and a significantly decreased left ventricular ejection fraction (LVEF 20–39%) were randomly assigned to three groups following primary percutaneous coronary intervention: Group A (n = 12) received a single intracoronary infusion of BMC (1.9 ± 1.2 × 108) at 3–7 days after AMI; Group B (n = 15) received BMC administration both at 3–7 days (2.0 ± 1.4 × 108) and at 3 months (2.1 ± 1.7 × 108); and the control group (CON, n = 12) received one placebo injection at 3–7 days. We noted no severe complications associated with the BMC transfer. The increase in LVEF evaluated by magnetic resonance imaging (MRI) after 12 months in Group B (11.7 ± 2.6%) was significantly greater than that in Group A (7.2 ± 1.6%, P < 0.001) or in CON (2.9 ± 2.0%, P < 0.001). Magnetic resonance imaging-derived myocardial infarct size decreased significantly in Group B compared with Group A (11.3 ± 2.7% vs. 6.3 ± 1.6%, P < 0.001).
Conclusion
Data from this preliminary study suggest that repeated BMC administration might be a safe and feasible therapeutic strategy for patients with large AMI.
63 citations
Authors
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Name | H-index | Papers | Citations |
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Jing Wang | 184 | 4046 | 202769 |
Jan-Åke Gustafsson | 147 | 1058 | 98804 |
Melitta Schachner | 135 | 861 | 67304 |
Yan Zhang | 107 | 2410 | 57758 |
Jau-Shyong Hong | 93 | 474 | 37172 |
Li Zhang | 92 | 918 | 35648 |
Charles G. Eberhart | 84 | 444 | 29920 |
Ying Lu | 83 | 343 | 24913 |
You-Lin Qiao | 78 | 595 | 23919 |
Wei Wei | 75 | 1068 | 29415 |
Weidong Le | 74 | 287 | 22551 |
Jin-Tai Yu | 66 | 439 | 20020 |
Wei Jiang | 65 | 660 | 18932 |
Lan Tan | 62 | 387 | 13828 |
Hua Li | 62 | 849 | 17933 |