Davangere University

About: Davangere University is a education organization based out in Davangere, India. It is known for research contribution in the topics: Nanofluid & Heat transfer. The organization has 236 authors who have published 413 publications receiving 3673 citations.

Significance of aluminium alloys particle flow through a parallel plates with activation energy and chemical reaction

Abstract: The paper communicates the flow, heat and mass transfer of a hybrid nanofluid (AA7072–AA7075/water) between the parallel plates, by incorporating chemical reactions, activation energy and heat source/sink effects. The governing partial differential equations are upgraded to ordinary differential equations by selecting relevant dimensionless variables and then are numerically resolved. Validation of the problem is confirmed between the present and existing work for the limiting cases and is found to be excellent concord. Moreover, the graphs are displayed to discuss the flow, heat and mass transport, friction drag, rate of heat and mass coefficient behaviour for different implanted parameters. It is noted that larger chemical reaction values minimize the concentration curve, while activation energy has the opposite pattern. Furthermore, upsurge values of heat source/sink parameter improve the rate of heat transport, but solid volume fraction reduces the drag friction. Also it has been discovered that AA7072–AA7075/water is a more efficient liquid than AA7072/water. Moving pistons, chocolate fillers, power transfer and compression are all examples of areas where the current research may be useful.

Antioxidant and cytotoxic potential of endophytic fungi isolated from medicinal plant Tragia involucrata L.

Abstract: Objective: The aim of the present study was to test the antioxidant and cytotoxic and DNA protection activities of ethyl acetate extracts of endophytic fungi isolated from Tragia involucrata Linn. (Euphorbiaceae). Materials and Methods: The 1, 1-diphenyl-2-picrylhydrazyl scavenging, reducing power, and total antioxidant assay were used to evaluate the antioxidant activity. Cytotoxic activity of endophytic fungal extracts against MCF-7 and MOLT-4 cell lines was carried out using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-2H-tetrazolium bromide method. Results: We have successfully isolated four endophytic fungi from T. involucrata, namely Penicillium citrinum CGJ-C1 (GenBank accession No. KT780618), P. citrinum CGJ-C2 (GenBank accession No. KP739821), Cladosporium sp. CGJ-D1 (GenBank accession No. KP739822), and Cryptendoxyla hypophloia CGJ-D2 (GenBank accession No. KT780619). The ethyl acetate extract of P. citrinum CGJ-C2 showed the highest antioxidant as well as cytotoxic activity among the four fungal extracts taken for the study. All the extracts showed moderate DNA protection activity. Conclusions: Further studies on the isolation and purification of the lead molecule will help in designing the novel therapy for different ailments associated with free radical generation. Abbreviations used: MCF-7: Breast Cancer Cell Line; MOLT-4: Human leukemia cell line; DPPH: 1, 1-diphenyl-2-picrylhydrazyl; MTT:3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide; DMSO: Dimethyl sulfoxide; H2O2: Hydrogen peroxide; NCI: National Cancer Institute.

Chitosan nanoparticles for tamoxifen delivery and cytotoxicity to MCF-7 and Vero cells

Abstract: In this study, tamoxifen citrate-loaded chitosan nanoparticles (tamoxcL-ChtNPs) and tamoxifen citrate-free chitosan nanoparticles (tamoxcF-ChtNPs) were prepared by an ionic gelation (IG) method. The physicochemical properties of the nanoparticles were ana- lyzed for particle size, zeta (ζ) potential, and other characteristics using photon correlation spectroscopy (PCS), zeta phase analysis light scattering (PALS), scanning electron microscopy (SEM), Fourier transform infrared (FTIR), and differential scanning calorimetry (DSC). The variation in particle size was assessed by changing the concentration of chitosan, pentasodium tripolyphosphate (TPP), and the pH of the solution. The optimized tamoxcL-ChtNPs showed mean diameter of 187 nm, polydispersity of 0.125, and ζ-potential of +19.1 mV. The encapsulation efficiency (EE) of tamoxifen citrate (tamoxc) increased at higher concentrations, and release of tamoxc from the chitosan matrix displayed controlled biphasic behavior. Those tamoxcL-ChtNPs tested for chemosensitivity showed dose- and time-dependent antiproliferative activity of tamoxc. Further, tamoxcL-ChtNPs were found to be hemocompatible with human red blood cells (RBCs) and safe by in vitro cytotoxicity tests, suggesting that they offer promise as drug delivery systems in therapy.

Critical values in axisymmetric flow of magneto-Cross nanomaterial towards a radially shrinking disk

Abstract: In this study, we investigated dual solutions for the influence of chemical reaction and radiation effect on axisymmetric flow of magneto-Cross nanomaterial towards a radially shrinking disk on tak...