Davangere University

About: Davangere University is a education organization based out in Davangere, India. It is known for research contribution in the topics: Nanofluid & Heat transfer. The organization has 236 authors who have published 413 publications receiving 3673 citations.

Optimization of 2,4 dichlorobiphenyl (PCB Congener) degradation by Pseudomonas spp.

Abstract: Pseudomonas spp consortium(GSa and GSb) was optimisedto degrade 2,4 dichlorbiphenyl (2,4 CB) in shakeflask culture The optimisation parameters such as concentrationof the substrates, rotations per minute, effectof substrate, concentration of sodium glutamate, pH,temperature, for degradation of 2,4 dichlorobiphenylwere evaluated The maximum degradation of 2, 4 CBwas observed under optimised conditions such as 35oC,pH 7, rpm- 130, and the concentration of 2,4 CB was90 ppm Supplimentation of 02% sodium glutamateand Surfactant Tween 80 resulted in highest amount of2,4 CB degradation which was measured spectrophotometricallyThe amount of chloride release with increasein biomass was estimated byMohr’s argentometricmethod Under these optimised conditions the consortiumGSa and GSb had the potential to degrade 2,4 CB, a PCB congener, perhaps a candidate for in-situbioremediation

Potential antileptospiral constituents from Phyllanthus amarus

Abstract: Background: Phyllanthus amarus (PA) is a well-known herb for its medicinal properties and widely used worldwide. PA has a significant role in Indian Ayurveda system of medicine for treating various ailments such as gonorrhea, menorrhagia, and other genital infections. Objectives: The aim of the study is to investigate antileptospiral activity and isolate the potential antileptospiral constituents of the methanol extract of PA (MPA). Materials and Methods: The primary pharmacological tests for leptospirosis were investigated by test tube dilution technique and microdilution technique. To examine the morphogenesis of experimental leptospirosis by morphologic and histological methods, albino mice were inoculated intraperitoneally with Leptospira interrogans sero group Icterohaemorrhagiae strains. Results: The activity-guided repeated fractionation for MPA through silica gel column chromatography yielded three compounds that exhibited antioxidant and in vitro, in vivo, and in silico antileptospiral activities. Based on diverse physicochemical and spectroscopic analyses (viz.,13C NMR,1H NMR, ultraviolet [UV], IR, and mass spectroscopy), the potential constituents were elucidated as 5-(3-(3,4-dimethoxybenzyl)-4-methoxy-2-(methoxymethyl)butyl)-4,7-dimethoxybenzo[d][1,3]dioxole(C1),1-(3-(3,4-dimethoxybenzyl)-4-methoxy-2-(methoxymethyl)butyl)-2,3,4,5tetramethoxybenzene(C2), and 4-(3-(3,4dimethoxybenzyl)-4-methoxy-2-(methoxymethyl)butyl)-3,6-dimethoxybenzene-1,2-diol (C3). The histopathological examinations of both kidney and liver showed promising activity with C3 at 75 and 100 μg/mL, respectively. Conclusion: The in vitro , in vivo, and in silico studies revealed that benzo methoxy class of compounds has great potential as antileptospiral agents.