Institution
Detroit Receiving Hospital
Healthcare•Detroit, Michigan, United States•
About: Detroit Receiving Hospital is a healthcare organization based out in Detroit, Michigan, United States. It is known for research contribution in the topics: Vancomycin & Population. The organization has 877 authors who have published 850 publications receiving 37202 citations. The organization is also known as: Detroit General.
Papers published on a yearly basis
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TL;DR: Substantial evidence is presented that the insulin-class growth factors have neuron-sparing effects against damage by radicals and ischemia and reperfusion, and may provide a fundamental basis for a rational approach to "cerebral resuscitation" that will allow substantial amelioration of the often dismal neurologic outcome now associated with resuscitation from cardiac arrest.
112 citations
Detroit Receiving Hospital1, Wayne State University2, Eugene Applebaum College of Pharmacy and Health Sciences3, University of Montana4, Albany College of Pharmacy and Health Sciences5, Boston Children's Hospital6, University of California, San Diego7, University of Washington8, Fred Hutchinson Cancer Research Center9, University of Michigan10, University of Southern California11, University of Minnesota12, University of Illinois at Urbana–Champaign13, University of Arkansas for Medical Sciences14, Albany Medical College15
TL;DR: In this paper, the authors present the new vancomycin consensus guidelines for dosing and monitoring, which recommend an AUC/MIC ratio of 400-600 mg*hour/L (assuming a broth microdilution MIC of 1 mg/L) to achieve clinical efficacy and ensure safety for patients being treated for serious methicillin resistant Staphylococcus aureus infections.
Abstract: Recent clinical data on vancomycin pharmacokinetics and pharmacodynamics suggest a reevaluation of current dosing and monitoring recommendations. The previous 2009 vancomycin consensus guidelines recommend trough monitoring as a surrogate marker for the target area under the curve over 24 hours to minimum inhibitory concentration (AUC/MIC). However, recent data suggest that trough monitoring is associated with higher nephrotoxicity. This document is an executive summary of the new vancomycin consensus guidelines for vancomycin dosing and monitoring. It was developed by the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists vancomycin consensus guidelines committee. These consensus guidelines recommend an AUC/MIC ratio of 400-600 mg*hour/L (assuming a broth microdilution MIC of 1 mg/L) to achieve clinical efficacy and ensure safety for patients being treated for serious methicillin-resistant Staphylococcus aureus infections.
112 citations
TL;DR: It is suggested that grapefruit juice increases trough concentrations of cyclosporine in blood, possibly by inhibiting pre-hepatic gut wall metabolism, and could be useful in optimizing therapy with this drug.
Abstract: Components of grapefruit juice have been shown to inhibit CYP3A4 activity, the enzyme involved in cyclosporine metabolism. Eleven medically stable patients (seven males, four females) receiving cyclosporine following kidney transplantation were instructed to take their usual dose of cyclosporine with water for 1 week (Phase 1), with grapefruit juice (8 ounces) for 1 week (Phase 2) and again with water for 1 week (Phase 3). Trough blood samples were obtained at the end of each phase for measurement of cyclosporine concentration using a specific monoclonal whole blood radioimmunoassay. Cyclosporine trough concentrations averaged 116.9 +/- 51.6 ng ml(-1) in the first phase, 145.3 +/- 44.7 ng ml(-1) with grapefruit juice (P < 0.05 compared with the first and third phases) and 111.2 +/- 56.1 ng ml(-1) in the third phase. Cyclosporine concentrations increased in 8 of 11 patients when given with grapefruit juice (mean increase 32%; range -4 to 97%) and declined in 10 of 11 when subjects resumed taking cyclosporine with water (mean decrease 27%). These results suggest that grapefruit juice increases trough concentrations of cyclosporine in blood, possibly by inhibiting pre-hepatic gut wall metabolism, and could be useful in optimizing therapy with this drug.
111 citations
TL;DR: The water and electrolyte content of cardiac and skeletal muscle from patients dying of congestive failure or recent myocardial infarction was compared with the composition of specimens from patients Dying of noncardiac causes, finding abnormalities in chemical composition well beyond the boundaries of a recent infarct were attributed to ischemia.
111 citations
TL;DR: The present study is concerned with a correlation of electrocardiographic and pathologic findings referable to the septal lesion in the remaining eighty-nine cases with infarction reaching the anatomic site of the bundle of His.
111 citations
Authors
Showing all 878 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Ronald N. Jones | 109 | 1169 | 54206 |
| Husseini K. Manji | 104 | 283 | 36624 |
| Paul E. Marik | 89 | 621 | 32719 |
| Michael J. Rybak | 77 | 420 | 24816 |
| John M. Carethers | 52 | 199 | 9723 |
| Renee C. LeBoeuf | 50 | 112 | 7017 |
| John W. Devlin | 48 | 234 | 11941 |
| Charles E. Lucas | 47 | 260 | 6768 |
| Jan Paul Muizelaar | 47 | 99 | 10934 |
| Vincent H. Tam | 45 | 184 | 7276 |
| Berton R. Moed | 42 | 154 | 5311 |
| James T. Fitzgerald | 42 | 120 | 7989 |
| David Edelman | 38 | 165 | 5346 |
| Donald P. Levine | 38 | 87 | 11611 |
| Scott A. Dulchavsky | 38 | 130 | 5669 |