Institution
Detroit Receiving Hospital
Healthcare•Detroit, Michigan, United States•
About: Detroit Receiving Hospital is a healthcare organization based out in Detroit, Michigan, United States. It is known for research contribution in the topics: Vancomycin & Population. The organization has 877 authors who have published 850 publications receiving 37202 citations. The organization is also known as: Detroit General.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: The value of complete hematologic study, including examination of the blood and bone marrow and imprints as well as sections of lymph nodes, for the diagnosis of lymphoblastomas has been indicated.
50 citations
••
TL;DR: The pharmacodynamic activities of vancomycin with or without gentamicin in an in vitro infection model with methicilin-resistant Staphylococcus aureus-infected fibrin-platelet clots and monotherapy regimens were similar in bacterial kill regardless of dosing frequency.
Abstract: We compared the pharmacodynamic activities of vancomycin with or without gentamicin in an in vitro infection model with methicilin-resistant Staphylococcus aureus-infected fibrin-platelet clots. Infected fibrin-platelet clots (FPCs) were prepared with human cryoprecipitate, human platelets, thrombin, and the organism (approximately 10[9] CFU of MRSA-494/g) and were suspended with monofilament line in an infection model capable of simulating human pharmacokinetics. Antibiotics were bolused to simulate vancomycin regimens of 2 g every 24 h (q24h), 1 g q12h, 500 mg q6h, and continuous infusion (steady-state concentration of 20 microg/ml) and gentamicin regimens of 1.5 mg/kg of body weight q12h and 5 mg/kg once daily (q.d.). Model experiments were performed in duplicate over 72 h. FPCs were removed from the models in quadruplicate at 0, 8, 24, 32, 48, 72 h, weighed, homogenized, diluted, and plated to determine colony counts. The inoculum density at 72 h was used to compare bactericidal activities between the regimens. All regimens containing vancomycin significantly decreased the bacterial inoculum compared to the growth control (P < 0.001). Vancomycin monotherapy regimens were similar in bacterial kill regardless of dosing frequency. The addition of gentamicin (either q12h or q.d.) significantly improved the bactericidal activity of the vancomycin q6h, q12h, and q24h regimens (P < 0.001). The greatest reduction in bacterial density at 72 h (P < 0.001) and the most rapid rate of kill (time to 99.9% killing) were achieved with the regimen consisting of 2 g of vancomycin q24h plus gentamicin (q.d. or q12h).
50 citations
••
TL;DR: It is found that the cost of outpatient therapy was substantial, although nonuniform, across payer types, and alternative outpatient therapies associated with lower risks for adverse events and lower costs should be considered.
Abstract: Intravenous antimicrobial therapy often continues after a patient is discharged from the hospital or it begins in the outpatient setting. Reimbursement for this therapy varies by payer. The United States Outpatient Parenteral Antibiotic Therapy (OPAT) Outcomes Registry is a valuable resource for quantifying cost by payer, as well as for describing practice patterns and adverse events related to intravenous antimicrobial therapy. To describe the reimbursement structure and cost of intravenous vancomycin home care therapy for four different types of payers, a survey of home infusion companies was done. Also surveyed were infusion programs participating in the OPAT Outcomes Registry, representing four different types of payers, to determine the cost of outpatient intravenous therapy. A retrospective cohort study of these infusion programs was conducted to describe practice patterns and to identify adverse events that resulted from intravenous vancomycin. We found that the cost of outpatient therapy was substantial, although nonuniform, across payer types. Alternative outpatient therapies associated with lower risks for adverse events and lower costs should be considered.
49 citations
••
TL;DR: The threshold for ischemia after head injury be redefined as a CBF of 20 mL/100 g/min, based on the clear distinction between survivors and nonsurvivors, and it is suggested that a measure of atrophy does not correlate with ultra-early CBF.
Abstract: Cerebral ischemic insults occur in at least 30% of severely head injured patients at a very early stage following trauma and are associated with early death. To date, the threshold for isc...
49 citations
••
TL;DR: The lack of consensus with regards to appropriate stress ulcer prophylaxis is apparent in this survey of Level I trauma centers, and for those institutions with a preferred agent, histamine-2-blockers were most common.
Abstract: Introduction
A number of issues concerning stress ulcer prophylaxis remain unresolved despite numerous randomized, controlled trials and several meta-analyses. The role of stress ulcer prophylaxis, particularly in trauma patients, is further complicated by the lack of trials utilizing clinically important bleeding as an endpoint. Given the lack of consensus regarding stress ulcer prophylaxis in trauma patients, prescribing practices at Level I trauma centers in the United States were assessed.
49 citations
Authors
Showing all 878 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ronald N. Jones | 109 | 1169 | 54206 |
Husseini K. Manji | 104 | 283 | 36624 |
Paul E. Marik | 89 | 621 | 32719 |
Michael J. Rybak | 77 | 420 | 24816 |
John M. Carethers | 52 | 199 | 9723 |
Renee C. LeBoeuf | 50 | 112 | 7017 |
John W. Devlin | 48 | 234 | 11941 |
Charles E. Lucas | 47 | 260 | 6768 |
Jan Paul Muizelaar | 47 | 99 | 10934 |
Vincent H. Tam | 45 | 184 | 7276 |
Berton R. Moed | 42 | 154 | 5311 |
James T. Fitzgerald | 42 | 120 | 7989 |
David Edelman | 38 | 165 | 5346 |
Donald P. Levine | 38 | 87 | 11611 |
Scott A. Dulchavsky | 38 | 130 | 5669 |