Dicle University

About: Dicle University is a education organization based out in Diyarbakır, Turkey. It is known for research contribution in the topics: Population & Catalysis. The organization has 3007 authors who have published 6368 publications receiving 94797 citations. The organization is also known as: Dicle Üniversitesi & Zanîngeha Dîcleyê.

Elevated serum levels of high mobility group box protein 1 (HMGB1) in patients with ankylosing spondylitis and its association with disease activity and quality of life

Abstract: This study was carried out to determine the serum levels of high mobility group box protein 1 (HMGB1) in patients with ankylosing spondylitis (AS) and to evaluate its correlation with disease activity and quality of life. According to our knowledge, it is the first trial evaluating HMGB1 levels in AS. Serum samples of 30 patients (18 males and 12 females) with AS and 29 healthy controls (HC) (15 females and 14 males) were collected. HMGB1 levels were measured by enzyme-linked immunosorbent assay, activity of disease was assessed according to the Bath AS Disease Activity Index (BASDAI), and functional status of patients was evaluated with Bath AS Functional Index (BASFI). Modified Schober, chest expansion values and AS Quality of Life Questionnaire (ASQoL) scores were noted. The serum levels of HMGB1 were obtained significantly increased in AS patients compared to HC (p 0.05), and CRP (p > 0.05) values. BASDAI, BASFI and ASQoL scores were also not correlated with serum levels of HMGB1 (p > 0.05). Our results suggest that HMGB1 might play an important role in the pathogenesis of AS; however, it seems not to be a good candidate for reflecting disease activity, functional abilities and the quality of life in patients with AS; on the other hand, the increased levels of HMGB1 in patients may open a new dimension for targeting this cytokine as a new therapy option in AS.

Clinical outcomes in patients who received lapatinib plus capecitabine combination therapy for HER2-positive breast cancer with brain metastasis and a comparison of survival with those who received trastuzumab-based therapy: a study by the Anatolian Society of Medical Oncology

Abstract: Purpose In this study, we investigated the effect of lapatinib plus capecitabine treatment in HER2-positive breast cancer patients with brain metastasis.

Synthesis, spectral characterization and electrochemical studies of copper(II) and cobalt(II) complexes with novel tetradentate salicylaldimines

Abstract: Several new complexes of Schiff bases obtained by the condensation of 1,2-bis(p-aminophenoxy)ethane and 1,2-bis(m-aminophenoxy)ethane with 3,5-di-tert-butyl-2-hydroxybenzaldehyde have been synthesized, and characterized by elemental analyses, FT-IR, UV–VIS, 1H NMR spectroscopy, magnetic susceptibility measurements and cyclic voltammetry. The metal to ligand ratios of the Co(II) and Cu(II) complexes were found to be 1 : 1. The coordination of the Schiff base appears to occur through the two azomethine nitrogens and two o-OH groups. Electrochemical data suggest the existence of copper(II)/copper(I) and cobalt(II)/cobalt(I) redox couples in DMSO along with an irreversible oxidation peak assigned to the oxidation of ligands for all of the complexes.