Institution
Dicle University
Education•Diyarbakır, Turkey•
About: Dicle University is a education organization based out in Diyarbakır, Turkey. It is known for research contribution in the topics: Population & Catalysis. The organization has 3007 authors who have published 6368 publications receiving 94797 citations. The organization is also known as: Dicle Üniversitesi & Zanîngeha Dîcleyê.
Topics: Population, Catalysis, Poison control, Adsorption, Medicine
Papers published on a yearly basis
Papers
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TL;DR: The freezing extender supplemented with 2.5 mM curcumin led to higher percentage of computer-assisted semen analyzer (CASA) sperm motility (65 ± 3%), when compared to the control, inositol and the 10 MM carnitine.
160 citations
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TL;DR: Values show that adsorption of heavy metal on MCR was an endothermic process and process of adsor adaptation was favoured at high temperatures.
156 citations
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TL;DR: The results suggest that the automatic recognition algorithm is applicable for distinguishing between alert, drowsy and sleep state in recordings that have not been used for the training.
155 citations
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Istanbul University1, Sakarya University2, Pamukkale University3, Erciyes University4, Istanbul Medipol University5, Marmara University6, Trakya University7, Namik Kemal University8, Gaziosmanpaşa University9, Cumhuriyet University10, Süleyman Demirel University11, Dicle University12, Yüzüncü Yıl University13, Düzce University14, Ondokuz Mayıs University15
TL;DR: Colistin-based combination therapy resulted in significantly higher microbiological eradication rates, relatively higher cure and 14-day survival rates, and lower in-hospital mortality compared to colistin monotherapy.
Abstract: The purpose of this investigation was to compare the efficacy of colistin-based therapies in extremely drug-resistant Acinetobacter spp. bloodstream infections (XDR-ABSI). A retrospective study was conducted in 27 tertiary-care centers from January 2009 to August 2012. The primary end-point was 14-day survival, and the secondary end-points were clinical and microbiological outcomes. Thirty-six and 214 patients [102 (47.7 %): colistin–carbapenem (CC), 69 (32.2 %): colistin–sulbactam (CS), and 43 (20.1 %: tigecycline): colistin with other agent (CO)] received colistin monotherapy and colistin-based combinations, respectively. Rates of complete response/cure and 14-day survival were relatively higher, and microbiological eradication was significantly higher in the combination group. Also, the in-hospital mortality rate was significantly lower in the combination group. No significant difference was found in the clinical (p = 0.97) and microbiological (p = 0.92) outcomes and 14-day survival rates (p = 0.79) between the three combination groups. Neither the timing of initial effective treatment nor the presence of any concomitant infection was significant between the three groups (p > 0.05) and also for 14-day survival (p > 0.05). Higher Pitt bacteremia score (PBS), Acute Physiology and Chronic Health Evaluation II (APACHE II) score, Charlson comorbidity index (CCI), and prolonged hospital and intensive care unit (ICU) stay before XDR-ABSI were significant risk factors for 14-day mortality (p = 0.02, p = 0.0001, p = 0.0001, p = 0.02, and p = 0.01, respectively). In the multivariable analysis, PBS, age, and duration of ICU stay were independent risk factors for 14-day mortality (p < 0.0001, p < 0.0001, and p = 0.001, respectively). Colistin-based combination therapy resulted in significantly higher microbiological eradication rates, relatively higher cure and 14-day survival rates, and lower in-hospital mortality compared to colistin monotherapy. CC, CS, and CO combinations for XDR-ABSI did not reveal significant differences with respect to 14-day survival and clinical or microbiological outcome before and after propensity score matching (PSM). PBS, age, and length of ICU stay were independent risk factors for 14-day mortality.
154 citations
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TL;DR: Investigating the effects of smoking on lipid peroxidation and paraoxonase activity in a healthy population found increased levels of serum MDA and decreased PON1 activities may be important in determining the oxidant/antioxidant imbalance in smokers.
Abstract: Oxidative stress plays an important role in the pathogenesis of some diseases such as lung cancer, chronic obstructive pulmonary disease, and atheroscleorosis. Smoking may enhance oxidative stress not only through the production of reactive oxygen radicals in smoke but also through weakening of the antioxidant defense systems. In this study, we investigated the effects of smoking on lipid peroxidation and paraoxonase activity in a healthy population. The study consisted of (n = 30) smokers and (n = 30) nonsmokers. The age of the population which is studied was 44.74 +/- 10.59 yr. The levels of serum malondialdehyde (MDA) and paraoxonase (PON1) activities were measured by the modified Buege method and the Eckerson method, respectively. Student's t-test was used to analyze the data. The serum MDA levels were significantly higher (p < .05) and serum PON1 activities were significantly lower (p < .001) in smokers than in nonsmokers. Thus, increased levels of serum MDA and decreased PON1 activities may be important in determining the oxidant/antioxidant imbalance in smokers.
151 citations
Authors
Showing all 3143 results
Name | H-index | Papers | Citations |
---|---|---|---|
Mustafa Yilmaz | 95 | 751 | 45011 |
Mehmet Dogan | 54 | 272 | 9838 |
Kazim Sahin | 54 | 289 | 8318 |
Tom J. Mabry | 42 | 459 | 13375 |
Mustafa Keskin | 35 | 231 | 4484 |
İnan Güler | 34 | 154 | 4571 |
Kemal Nas | 30 | 166 | 3456 |
Fatih Demirci | 30 | 194 | 3783 |
Salih Hosoglu | 29 | 86 | 2928 |
Remzi Çevik | 28 | 107 | 2946 |
Ali Gur | 28 | 99 | 2974 |
Carl W. Fairhurst | 28 | 62 | 2648 |
Mehmet Gul | 27 | 188 | 2410 |
Hamdi Temel | 27 | 124 | 1945 |
Metin Kilinc | 27 | 132 | 1930 |