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TL;DR: In this paper, a 10MW MgB2 superconducting direct-drive generator and the cost break down of the nacelle components are presented and scaled up to a turbine with a rotor diameter of up to 280 m. The partial load efficiency of the generator is evaluated for a constant cooling power of 0, 50, and 100 kW.
Abstract: A method for comparing the levelized cost of energy (LCoE) of different superconducting drive trains is introduced. The properties of a 10-MW MgB2 superconducting direct-drive generator and the cost break down of the nacelle components are presented and scaled up to a turbine with a rotor diameter of up to 280 m. The partial load efficiency of the generator is evaluated for a constant cooling power of 0, 50, and 100 kW, and the annual energy production is used to determine the impact on the LCoE.
49 citations
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TL;DR: An alternative approach, opening for specified uncertainties is shown to correct this defect, and a simple fire detection system is discussed.
49 citations
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TL;DR: In this paper, the semi-quantitative layer of protection analysis (LOPA) approach is used to estimate reactive chemical risk, and the probabilities or frequencies of failure scenarios are addressed.
49 citations
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TL;DR: In this paper, a unified approach for modeling fuel sprays for internal combustion engines is presented, where the fuel injection process has been divided in three subprocesses, namely, primary atomization, drop deformation and aerodynamic drag, and secondary atomization.
Abstract: A unified approach toward modeling fuel sprays for internal combustion engines is presented in this work. The fuel injection process has been divided in three subprocesses, namely, primary atomization, drop deformation and aerodynamic drag, and secondary atomization. Two different models have been used for the primary atomization, depending on whether a high-pressure swirl atomizer or a multihole nozzle is used. The drop deformation and secondary atomization have been modeled based on the physical properties of the system, independent of the way the droplets were created. The secondary atomization has been further divided into four breakup regimes, based on experimental observations reported in the literature. The model has been validated using a wide array of experimental conditions, ranging from gasoline to diesel sprays, in nonevaporating conditions. Overall, the model performs well, predicting correct trends for the spray characteristics, without the need for recalibration.
49 citations
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TL;DR: Evaluated variant calling pipelines using the Genome in a Bottle Consortium, “synthetic-diploid” and simulated WGS datasets facilitate the standardization of benchmarking analysis of bioinformatics pipelines for reliable variant detection, which is critical in genetics-based medical research and clinical applications.
Abstract: Advances in next-generation sequencing technology have enabled whole genome sequencing (WGS) to be widely used for identification of causal variants in a spectrum of genetic-related disorders, and provided new insight into how genetic polymorphisms affect disease phenotypes. The development of different bioinformatics pipelines has continuously improved the variant analysis of WGS data. However, there is a necessity for a systematic performance comparison of these pipelines to provide guidance on the application of WGS-based scientific and clinical genomics. In this study, we evaluated the performance of three variant calling pipelines (GATK, DRAGEN and DeepVariant) using the Genome in a Bottle Consortium, "synthetic-diploid" and simulated WGS datasets. DRAGEN and DeepVariant show better accuracy in SNP and indel calling, with no significant differences in their F1-score. DRAGEN platform offers accuracy, flexibility and a highly-efficient execution speed, and therefore superior performance in the analysis of WGS data on a large scale. The combination of DRAGEN and DeepVariant also suggests a good balance of accuracy and efficiency as an alternative solution for germline variant detection in further applications. Our results facilitate the standardization of benchmarking analysis of bioinformatics pipelines for reliable variant detection, which is critical in genetics-based medical research and clinical applications.
49 citations
Authors
Showing all 1935 results
Name | H-index | Papers | Citations |
---|---|---|---|
Sergio A. Jimenez | 84 | 416 | 28486 |
Hao Yu | 81 | 981 | 27765 |
Clifford Nass | 65 | 195 | 22615 |
Odd M. Faltinsen | 50 | 247 | 11374 |
Otilia Mó | 46 | 382 | 8641 |
Zefeng Zhou | 38 | 84 | 8653 |
Asgeir J. Sørensen | 35 | 221 | 4459 |
Michael Havbro Faber | 33 | 260 | 4372 |
Deborah Greaves | 31 | 194 | 3141 |
Alessandro Toffoli | 30 | 117 | 2494 |
Yang Miang Goh | 27 | 53 | 2051 |
Narasi Sridhar | 27 | 202 | 3017 |
Elzbieta M. Bitner-Gregersen | 26 | 109 | 2234 |
Jørgen Amdahl | 26 | 150 | 2157 |
Christopher D. Taylor | 25 | 143 | 2840 |