Institution
DST Systems
About: DST Systems is a based out in . It is known for research contribution in the topics: Population & Acquired immunodeficiency syndrome (AIDS). The organization has 1341 authors who have published 1336 publications receiving 25018 citations.
Topics: Population, Acquired immunodeficiency syndrome (AIDS), HPV infection, Candida albicans, Filter (signal processing)
Papers published on a yearly basis
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TL;DR: A comprehensive laboratory evaluation of the geotechnical and geoenvironmental properties of five predominant types of construction and demolition (C&D) waste materials was undertaken in this article, and the results showed that these materials are suitable for reuse.
Abstract: A comprehensive laboratory evaluation of the geotechnical and geoenvironmental properties of five predominant types of construction and demolition (C&D) waste materials was undertaken in th...
336 citations
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TL;DR: Overall HPV prevalence was not associated with age, however, significant associations with age were observed when specific categories of HPV, nononcogenic, and unclassified HPV infections were considered.
Abstract: Male sexual behavior influences the rates of cervical dysplasia and invasive cervical cancer, as well as male human papillomavirus (HPV) infection and disease. Unfortunately, little is known regarding male HPV type distribution by age and across countries. In samples combined from the coronal sulcus, glans penis, shaft, and scrotum of 1,160 men from Brazil, Mexico, and the United States, overall HPV prevalence was 65.2%, with 12.0% oncogenic types only, 20.7% nononcogenic types only, 17.8% both oncogenic and nononcogenic, and 14.7% unclassified infections. Multiple HPV types were detected in 25.7% of study participants. HPV prevalence was higher in Brazil (72.3%) than in the United States (61.3%) and Mexico (61.9%). HPV16 (6.5%), HPV51 (5.3%), and HPV59 (5.3%) were the most commonly detected oncogenic infections, and HPV84 (7.7%), HPV62 (7.3%), and HPV6 (6.6%) were the most commonly detected nononcogenic infections. Overall HPV prevalence was not associated with age. However, significant associations with age were observed when specific categories of HPV, nononcogenic, and unclassified HPV infections were considered. Studies of HPV type distribution among a broad age range of men from multiple countries is needed to fill the information gap internationally with respect to our knowledge of HPV infection in men.
326 citations
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TL;DR: In lopinavir-naive, treatment-experienced patients, darunavir-ritonavir was non-inferior to lop Scandinavian-rit onavir treatment in terms of the virological endpoint, and should therefore be considered as a treatment option for this population.
322 citations
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TL;DR: In this early bactericidal activity study, 75 patients with smear-positive pulmonary tuberculosis were randomized to once-daily oral TMC207 and the drug was well tolerated, and no study drug-related serious adverse events occurred.
Abstract: Tibotec Medicinal Compound 207 (TMC207) is a novel diarylquinoline with a unique mode of action that targets mycobacterial ATP synthase. TMC207 exhibits high in vitro activity against mycobacterial strains either susceptible or resistant to all first-line and many second-line drugs, including fluoroquinolones, and has shown exceptional in vivo activity against several mycobacterial species in different animal models. In this early bactericidal activity study, 75 treatment-naive patients with smear-positive pulmonary tuberculosis were randomized to once-daily oral TMC207 (25 mg, 100 mg, or 400 mg), 600 mg rifampin (RIF), or 300 mg isoniazid (INH) for 7 days. Sixteen-hour overnight sputum collected at baseline and on each treatment day was plated in serial dilutions on selective agar plates. The bactericidal activity was expressed as the log(10) decrease in CFU/ml sputum/day. Pharmacokinetic sampling was performed on day 7 of TMC207 administration up to 24 h postdose. The decreases in log(10) CFU counts (+/- standard deviation) from baseline to day 7 were 0.04 +/- 0.46 for 25 mg TMC207 (n = 14), 0.26 +/- 0.64 for 100 mg TMC207 (n = 14), 0.77 +/- 0.58 for 400 mg TMC207 (n = 14), 1.88 +/- 0.74 for INH (n = 11), and 1.70 +/- 0.71 for RIF (n = 14). Significant bactericidal activity of 400 mg TMC207 was observed from day 4 onward and was similar in magnitude to those of INH and RIF over the same period. The pharmacokinetics of TMC207 were linear across the dose range. In summary, TMC207 demonstrated bactericidal activity with a delayed onset and was well tolerated, and no study drug-related serious adverse events occurred.
255 citations
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TL;DR: All the six terpenoids tested exhibit excellent synergistic activity with fluconazole against a flu Conazole resistant strain of C. albicans, which may find use in antifungal chemotherapy, not only as antIfungal agents but also as synergistic agents along with conventional drugs like fluconAZole.
243 citations
Authors
Showing all 1341 results
Name | H-index | Papers | Citations |
---|---|---|---|
C. N. R. Rao | 133 | 1646 | 86718 |
John Newman | 84 | 479 | 33760 |
Shabir A. Madhi | 79 | 561 | 29863 |
Thalappil Pradeep | 76 | 581 | 24664 |
Bansi D. Malhotra | 75 | 375 | 19419 |
Robin M. Warren | 74 | 363 | 19049 |
Peter G. Ryan | 67 | 488 | 18096 |
Ashutosh Sharma | 66 | 570 | 16100 |
Rodolfo Carosi | 62 | 562 | 14781 |
Graeme S. Cumming | 61 | 239 | 17312 |
Gerhard Walzl | 61 | 257 | 12080 |
Linda Richter | 61 | 325 | 20160 |
Natalie A. Sims | 60 | 228 | 13166 |
David Grémillet | 59 | 213 | 9813 |
Carlos A. Silva | 55 | 765 | 17298 |