C
Clara C. Elbers
Researcher at Utrecht University
Publications - 12
Citations - 2274
Clara C. Elbers is an academic researcher from Utrecht University. The author has contributed to research in topics: Genome-wide association study & Metabolic syndrome. The author has an hindex of 10, co-authored 12 publications receiving 2104 citations. Previous affiliations of Clara C. Elbers include University of Groningen & University Medical Center Utrecht.
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Journal ArticleDOI
Human Dectin-1 Deficiency and Mucocutaneous Fungal Infections
Bart Ferwerda,Gerben Ferwerda,Theo S. Plantinga,Janet A. Willment,Annemiek B. van Spriel,Hanka Venselaar,Clara C. Elbers,Melissa D. Johnson,Alessandra Cambi,Cristal Huysamen,Liesbeth Jacobs,Trees Jansen,Karlijn Verheijen,Laury J.N. Masthoff,Servaas A. Morré,Gert Vriend,David L. Williams,John R. Perfect,Leo A. B. Joosten,Cisca Wijmenga,Jos W. M. van der Meer,Gosse J. Adema,Bart Jan Kullberg,Gordon D. Brown,Mihai G. Netea +24 more
TL;DR: A family in which four women who were affected by either recurrent vulvovaginal candidiasis or onychomycosis had the early-stop-codon mutation Tyr238X in the beta-glucan receptor dectin-1, explaining why dectIn-1 deficiency was not associated with invasive fungal infections and highlighting the specific role of dect in human mucosal antifungal defense.
Journal ArticleDOI
Whole-genome sequence variation, population structure and demographic history of the Dutch population
Laurent C. Francioli,Androniki Menelaou,Sara L. Pulit,Freerk van Dijk,Pier Francesco Palamara,Clara C. Elbers,Pieter B. Neerincx,Kai Ye,Kai Ye,Victor Guryev,Wigard P. Kloosterman,Patrick Deelen,Abdel Abdellaoui,Elisabeth M. van Leeuwen,Mannis van Oven,Martijn Vermaat,Mingkun Li,Jeroen F. J. Laros,Lennart C. Karssen,Alexandros Kanterakis,Najaf Amin,Jouke-Jan Hottenga,Eric-Wubbo Lameijer,Mathijs Kattenberg,Martijn Dijkstra,Heorhiy Byelas,Jessica van Setten,Barbera D. C. van Schaik,Jan Bot,Isaac J. Nijman,Ivo Renkens,Tobias Marschall,Alexander Schönhuth,Jayne Y. Hehir-Kwa,Robert E. Handsaker,Robert E. Handsaker,Paz Polak,Mashaal Sohail,Mashaal Sohail,Dana Vuzman,Fereydoun Hormozdiari,David van Enckevort,Hailiang Mei,Vyacheslav Koval,Matthijs Moed,K. Joeri van der Velde,Fernando Rivadeneira,Fernando Rivadeneira,Fernando Rivadeneira,Karol Estrada,Carolina Medina-Gomez,Aaron Isaacs,Aaron Isaacs,Steven A. McCarroll,Marian Beekman,Anton J. M. de Craen,H. Eka D. Suchiman,Albert Hofman,Ben A. Oostra,André G. Uitterlinden,Gonneke Willemsen,Mathieu Platteel,Jan H. Veldink,Leonard H. van den Berg,Steven J. Pitts,Shobha Potluri,Purnima Sundar,David R. Cox,David R. Cox,Shamil R. Sunyaev,Johan T. den Dunnen,Mark Stoneking,Peter de Knijff,Manfred Kayser,Qibin Li,Yingrui Li,Yuanping Du,Ruoyan Chen,Hongzhi Cao,Ning Li,Sujie Cao,Jun Wang,Jasper A. Bovenberg,Itsik Pe'er,P. Eline Slagboom,Cornelia M. van Duijn,Dorret I. Boomsma,Gert-Jan B. van Ommen,Paul I.W. de Bakker,Paul I.W. de Bakker,Morris A. Swertz,Cisca Wijmenga +91 more
TL;DR: The Genome of the Netherlands (GoNL) Project is described, in which the whole genomes of 250 Dutch parent-offspring families were sequenced and a haplotype map of 20.4 million single-nucleotide variants and 1.2 million insertions and deletions were constructed.
Journal ArticleDOI
Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease
Adam S. Butterworth,Peter S. Braund,Martin Farrall,Robert J. Hardwick,Danish Saleheen,J F Peden,Nicole Soranzo,John C. Chambers,Suthesh Sivapalaratnam,Marcus E. Kleber,Brendan J. Keating,Atif Qasim,Norman Klopp,Jeanette Erdmann,Themistocles L. Assimes,Stephen G. Ball,Anthony J. Balmforth,Timothy A. Barnes,Hanneke Basart,Jens Baumert,Connie R. Bezzina,Eric Boerwinkle,Bernhard O. Boehm,Jessy Brocheton,Peter Bugert,François Cambien,Robert Clarke,Veryan Codd,Rory Collins,David Couper,L. Adrienne Cupples,Jonas S.S.G. de Jong,Patrick Diemert,Kenechi Ejebe,Clara C. Elbers,Paul Elliott,Myriam Fornage,Maria Grazia Franzosi,Philippe M. Frossard,Stephen F. Garner,Anuj Goel,Alison H. Goodall,Christian Hengstenberg,Sarah E. Hunt,John J.P. Kastelein,Olaf H. Klungel,Harald Klüterr,Kerstin Koch,Inke R. König,Angad S. Kooner,Reijo Laaksonen,Mark Lathrop,Mingyao Li,Kiang Liu,Ruth McPherson,Muntaser D. Musameh,Solomon K. Musani,Christopher P. Nelson,Christopher J. O'Donnell,Halit Ongen,George J. Papanicolaou,Annette Peters,Bas J M Peters,Simon C. Potter,Bruce M. Psaty,Liming Qu,Daniel J. Rader,Asif Rasheed,Catherine M. Rice,James Scott,Udo Seedorf,Joban Sehmi,Nona Sotoodehnia,Klaus Stark,Jonathan Stephens,C. Ellen van der Schoot,Yvonne T. van der Schouw,Unnur Thorsteinsdottir,Maciej Tomaszewski,Pim van der Harst,Ramachandran S. Vasan,Arthur A.M. Wilde,Christina Willenborg,Bernhard R. Winkelmann,Moazzam Zaidi,Weihua Zhang,Andreas Ziegler,Paul I.W. de Bakker,Wolfgang Koenig,Winfried März,Mieke D. Trip,Muredach P. Reilly,Sekar Kathiresan,Heribert Schunkert,Anders Hamsten,Alistair S. Hall,Jaspal S. Kooner,Simon G. Thompson,John R. Thompson,Panos Deloukas,Willem H. Ouwehand,Hugh Watkins,John Danesh,Nilesh J. Samani,Timothy A. Barnes,Timothy A. Barnes,Suzanne Rafelt,Nienke Bruinsma,Lukas R.C. Dekker,José P. Henriques,Karel T. Koch,Karel T. Koch,Robbert J. de Winter,Marco Alings,Cor F. Allaart,Anton P.M. Gorgels,Freek W. Verheugt,Martina Mueller,Christa Meisinger,Stephanie DerOhannessian,Nehal N. Mehta,Jane F. Ferguson,Hakon Hakonarson,William H. Matthai,Robert L. Wilensky,Jemma C. Hopewell,Sarah Parish,Pamela Linksted,J. Notman,Hector M. González,A. Young,T. Ostley,A. Munday,N. Goodwin,V. Verdon,Svati H. Shah,Laura K. Cobb,Cathryn Edwards,Carol A. Mathews,R. Gunter,J. Benham,Christopher Davies,M. Cobb,J. Crowther,Arthur Mark Richards,M. Silver,S. Tochlin,S. Mozley,Sarah Clark,M. Radley,K. Kourellias,Per Georg Olsson,Simona Barlera,Gianni Tognoni,Stephan Rust,Gerd Assmann,Simon Heath,Diana Zelenika,Ivo Gut,Fiona Green,John F. Peden,Anette Aly,Karolina Anner,Karin Björklund,Gun Blomgren,Barbro Cederschiöld,Karin Danell-Toverud,Per Eriksson,Ulla Grundstedt,Merja Heinonen,Mai Lis Hellénius,Ferdinand M. van't Hooft,Karin Husman,Jacob Lagercrantz,Anita Larsson,Malin Larsson,Magnus Mossfeldt,Anders Mälarstig,Gunnar O Olsson,Maria Sabater-Lleal,Bengt Sennblad,Angela Silveira,Rona J. Strawbridge,Birgitta Söderholm,John Öhrvik,Khan Shah Zaman,Nadeem Hayat Mallick,Muhammad Azhar,Abdus Samad,M. Ishaq,Nabi Shah,Maria Samuel,Muredach P. Reilly,Muredach P. Reilly,Hilma Holm,Michael Preuss,Alexandre F.R. Stewart,Maja Barbalić,Christian Gieger,Devin Absher,Zouhair Aherrahrou,Hooman Allayee,David Altshuler,Sonia S. Anand,Karl Andersen,Jeffrey L. Anderson,Diego Ardissino,Lewis C. Becker,Diane M. Becker,Klaus Berger,Joshua C. Bis,S. Matthijs Boekholdt,Morris J. Brown,Mary Susan Burnett,Ian Buysschaert,John F. Carlquist,Li Chen,Robert W. Davies,George Dedoussis,Abbas Dehghan,Serkalem Demissie,Joseph M. Devaney,Ron Do,Angela Doering,Nour Eddine El Mokhtari,Stephen G. Ellis,Roberto Elosua,James C. Engert,Stephen E. Epstein,Ulf de Faire,Marcus Fischer,Aaron R. Folsom,Jennifer Freyer,Bruna Gigante,Domenico Girelli,Solveig Gretarsdottir,Vilmundur Gudnason,Jeffrey R. Gulcher,Stephanie Tennstedt,Eran Halperin,Naomi Hammond,Stanley L. Hazen,Albert Hofman,Benjamin D. Horne,Thomas Illig,Carlos Iribarren,Gregory T. Jones,J. Wouter Jukema,Michael A. Kaiser,Lee M. Kaplan,Kay-Tee Khaw,Joshua W. Knowles,G. Kolovou,Augustine Kong,Diether Lambrechts,Karin Leander,Wolfgang Lieb,Guillaume Lettre,Christina Loley,Andrew J. Lotery,Pier Mannuccio Mannucci,Seraya Maouche,Nicola Martinelli,Pascal P. McKeown,Thomas Meitinger,Olle Melander,Pier Angelica Merlini,Vincent Mooser,Thomas M. Morgan,Thomas W. Mühleisen,Joseph B. Muhlestein,Kiran Musunuru,Janja Nahrstaedt,Markus M. Nöthen,Oliviero Olivieri,Flora Peyvandi,Riyaz S. Patel,Christopher Patterson,Arshed A. Quyyumi,Loukianos S. Rallidis,Frits R. Roosendaal,Diana Rubin,Veikko Salomaa,M. Lourdes Sampietro,M. S. Sandhu,Eric E. Schadt,Arne Schäfer,Arne Schillert,Stefan Schreiber,Jürgen Schrezenmeir,Stephen M. Schwartz,David S. Siscovick,Mohan U. Sivananthan,Albert V. Smith,Tamara B. Smith,Jaapjan D. Snoep,John A. Spertus,Kari Stefansson,Kathy Stirrups,Monika Stoll,W.H. Wilson Tang,Gudmundur Thorgeirsson,Gudmar Thorleifsson,André G. Uitterlinden,Andre M. van Rij,Benjamin F. Voight,Nicholas J. Wareham,George A. Wells,H.-Erich Wichmann,Jaqueline C M Witteman,Benjamin J. Wright,Shu Ye,Thomas Quertermous,Stefan Blankenberg,Robert Roberts,N. Charlotte Onland-Moret,Jessica van Setten,W. M. Monique Verschuren,Jolanda M. A. Boer,Cisca Wijmenga,Marten H. Hofker,Anke-Hilse Maitland-van der Zee,Anthonius de Boer,Diederick E. Grobbee,Tony Attwood,Stephanie Belz,Peter S. Braund,Peter S. Braund,Jason D. Cooper,Abi Crisp-Hihn,Nicola Foad,Jay Gracey,Emma Gray,Rhian Gwilliams,Susanne Heimerl,Jennifer Jolley,Unni Krishnan,Heather Lloyd-Jones,Ingrid Lugauer,Per Lundmark,Jasbir S. Moore,David Muir,Elizabeth Murray,Jessica Neudert,David Niblett,Karen O'Leary,Helen Pollard,Angela Rankin,Catherine M. Rice,Hendrik B. Sager,Jennifer G. Sambrook,Gerd Schmitz,Michael Scholz,Laura Schroeder,Ann Christine Syvannen,Chris Wallace +355 more
TL;DR: This large-scale gene-centric analysis has identified several novel genes for CAD that relate to diverse biochemical and cellular functions and clarified the literature with regard to many previously suggested genes.
Journal ArticleDOI
Using genome-wide pathway analysis to unravel the etiology of complex diseases.
Clara C. Elbers,Kristel R. van Eijk,Lude Franke,Lude Franke,Flip Mulder,Yvonne T. van der Schouw,Cisca Wijmenga,N. Charlotte Onland-Moret +7 more
TL;DR: This study analyzed data from two GWAS on type 2 diabetes and found that incorporating gene networks and pathway classification tools into the analysis can point toward significantly overrepresented molecular pathways, which cannot be picked up using traditional single‐locus analyses.
Journal ArticleDOI
Homocysteine and Coronary Heart Disease: Meta- analysis of MTHFR Case-Control Studies, Avoiding Publication Bias
Robert Clarke,Derrick A Bennett,Sarah Parish,Petra Verhoef,Mariska Dötsch-Klerk,Mark Lathrop,Peng Xu,Børge G. Nordestgaard,Hilma Holm,Jemma C. Hopewell,Danish Saleheen,Toshihiro Tanaka,Sonia S. Anand,John C. Chambers,Marcus E. Kleber,Willem H. Ouwehand,Yoshiji Yamada,Clara C. Elbers,Bas J M Peters,Alexandre F.R. Stewart,Muredach M. Reilly,Barbara Thorand,Salim Yusuf,James C. Engert,Themistocles L. Assimes,Jaspal S. Kooner,John Danesh,Hugh Watkins,Nilesh J. Samani,Rory Collins,Richard Peto +30 more
TL;DR: A meta-analysis of unpublished datasets suggests that an increase in homocysteine levels is not likely to result in a increase in risk of coronary heart disease.