German Red Cross

About: German Red Cross is a healthcare organization based out in Berlin, Germany. It is known for research contribution in the topics: Transplantation & Mesenchymal stem cell. The organization has 653 authors who have published 1146 publications receiving 40111 citations. The organization is also known as: Deutsches Rotes Kreuz & DRK.

Introduction of principles of blood management to healthy donor bone marrow harvesting.

Abstract: Background and objectives Patient blood (more accurately: haemoglobin, Hb) management (PBM) aims to optimize endogenous Hb production and to minimize iatrogenic Hb loss while maintaining patient safety and optimal effectiveness of medical interventions. PBM was adopted as policy for patients by the World Health Organization (WHO), and, all the more, should be applied to healthy donors. Materials and methods Observational data from 489 bone marrow (BM) donors were retrospectively analysed, and principles of patient blood management were applied to healthy volunteer BM donations. Results and conclusion We managed to render BM aspiration safe for donors, notably completely avoiding the collection of autologous blood units and blood transfusions through iron management, establishment and curation of high-yield aspiration technique, limitation of collection volume to 1·5% of donor body weight and development of volume prediction algorithms for the requested cell dose.

Immunologic reconstitution following hematopoietic stem cell transplantation despite lymph node paucity in NF-κB-inducing kinase deficiency.

Abstract: This case demonstrates successful immune reconstitution following hematopoietic stem cell transplantation in NIK deficiency.

Design Modifications and Optimization of a Commercially Available Knee Simulator

Abstract: To determine the wear behavior of knee endoprostheses, implants are tested in knee simulators before being introduced to the market. Implants may undergo mechanical failure and wear debris is generated. The magnitude and morphology of this debris are determined to gain information about its biological reactivity. In this study, we describe the modifications made to the AMTI multistation knee simulator. The simulator is not capable to ensure a medially biased load distribution as required per ISO 14243, and therefore the usage of the simulator is limited. Thus, simulator modifications were made to implement a wear test as outlined in ISO 14243, and to improve both user-friendliness of operation and cost of simulation. In particular, this involved modifying the implant holders and controlling implant kinematics during the simulation. For component design, a 3D computer-aided design software was used. After the manufacturing of all components had been completed, the redesigned system was put into operation. In a final wear test, functionality and conformance with the ISO standard were tested for the modified simulator. After implementation of design modifications, it is possible to run wear tests with a medially biased load distribution according to ISO 14243.

Time-resolved and spatio-temporal analysis of complex cognitive processes and their role in disorders like developmental dyscalculia

Abstract: The aim of this article is to report on the importance and challenges of a time-resolved and spatio-temporal analysis of fMRI data from complex cognitive processes and associated disorders using a study on developmental dyscalculia (DD). Participants underwent fMRI while judging the incorrectness of multiplication results, and the data were analyzed using a sequence of methods, each of which progressively provided more a detailed picture of the spatio-temporal aspect of this disease. Healthy subjects and subjects with DD performed alike behaviorally, though they exhibited parietal disparities using traditional “voxel-based” group analyses. Further and more detailed differences, however, surfaced with a “time-resolved” examination of the neural responses during the experiment. While performing intergroup comparisons, a third group of subjects with dyslexia but with no arithmetic difficulties was included to test the specificity of the analysis and strengthen the statistical base with overall 58 subjects. Surprisingly, the analysis showed a functional dissimilarity during an initial reading phase for the group of dyslexic but otherwise normal subjects, with respect to controls, though only numerical digits and no alphabetic characters were presented. Thus, our results suggest that “time-resolved multivariate” analysis of complex experimental paradigms has the ability to yield powerful new clinical insights about abnormal brain function. Similarly, a detailed compilation of aberrations in the functional cascade may have much greater potential to delineate the core processing problems in mental disorders. © 2012 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 22, 81–96, 2012 © 2012 Wiley Periodicals, Inc.