Institution
German Red Cross
Healthcare•Berlin, Germany•
About: German Red Cross is a healthcare organization based out in Berlin, Germany. It is known for research contribution in the topics: Transplantation & Mesenchymal stem cell. The organization has 653 authors who have published 1146 publications receiving 40111 citations. The organization is also known as: Deutsches Rotes Kreuz & DRK.
Topics: Transplantation, Mesenchymal stem cell, Population, Stem cell, Antigen
Papers published on a yearly basis
Papers
More filters
••
TL;DR: Five different implant designs were investigated in an experimental set-up and the long-term titanium release was measured, and the modular connections were inspected for corrosion processes and signs of fretting.
Abstract: Modular neck implants are an attractive treatment tool in total hip replacement. Concerns remain about the mechanical stability and metal ion release caused by the modular connection. Five different implant designs were investigated in an experimental set-up. In vivo conditions were simulated and the long-term titanium release was measured. Finally, the modular connections were inspected for corrosion processes and signs of fretting. No mechanical failure or excessive corrosion could be identified for the implants tested. The titanium releases measured were extremely low compared to in vivo and in vitro studies and were not in a critical range.
98 citations
••
TL;DR: The yield of NAT after testing more than 3.6 million donations in central Europe is reported and HCV and HIV‐1 NAT of all blood donations was initiated at institutions in January 1997.
98 citations
••
TL;DR: In this paper, a histopathological study was carried out on 27 patients with chronic inflammatory liver disease and clinical and biochemical evidence of cholestasis who had either mitochondrial antibodies against mitochondrial antigen fractions of 1.19 density (PBC antigen) or 1.13 density (CAH-PBC mixed-type antigen)
Abstract: A histopathological study was carried out on 27 patients with chronic inflammatory liver disease and clinical and/or biochemical evidence of cholestasis who had either mitochondrial antibodies against mitochondrial antigen fractions of 1.19 density (“PBC antigen”; 14 cases) or of 1.13 density (“CAH-PBC mixed-type antigen”; 13 cases). For comparison, the liver biopsies of 17 patients with chronic-aggressive hepatitis (CAH) and antinuclear and/or anti-smooth muscle antibodies but without cholestasis and mitochondrial antibodies, were evaluated. The 14 patients with mitochondrial antibodies against the PBC antigen showed the typical histological features of primary biliary cirrhosis (PBC). The 13 patients with mitochondrial antibodies against the CAH-PBC mixed-type antigen had heterogenous liver alterations. In 11 cases highly active CAH and/or active postnecrotic cirrhosis (AC) were found both with augmented ductular proliferation. Some of these cases showed distinct criteria of PBC as early bile duct lesions or absence of regular bile ducts. The liver histology of one case corresponded to classical PBC; another case to chronic persistent hepatitis. The CAH-patients without cholestasis and mitochondrial antibodies only occasionally showed bile duct proliferation. In conclusion, a high correlation was found between mitochondrial antibodies against the CAH-PBC mixed-type antigen and highly active CAH or early AC with augmented ductular proliferation. This represents an overlapping of CAH and PBC. In contrast, the cases with antibodies reacting to the PBC antigen showed the slowly progressive liver changes of typical PBC.
96 citations
••
McMaster University1, Charité2, Ghent University3, University of Genoa4, Creighton University5, Erasmus University Rotterdam6, Teikyo University7, University of Cape Town8, Imperial College London9, Federal University of Bahia10, Georgia Regents University11, University of South Florida12, National Institutes of Health13, Seconda Università degli Studi di Napoli14, Laval University15, Universidade Federal de Minas Gerais16, University of Oslo17, Leiden University18, University of Porto19, University of Amsterdam20, University of Helsinki21, Hacettepe University22, Medical University of Łódź23, Guangzhou Medical University24, Tishreen University25, University of Barcelona26, University of Chicago27, Monash University28, National and Kapodistrian University of Athens29, Nippon Medical School30, University of Aberdeen31, Medical University of Warsaw32, University of Manitoba33, Celal Bayar University34, Transilvania University of Brașov35, French Institute of Health and Medical Research36, University of Modena and Reggio Emilia37, University of Tennessee Health Science Center38, University of Ghana39, University of Wisconsin-Madison40, University of British Columbia41, University of Montpellier42, University of Manchester43, Aarhus University44, Vilnius University45, University of Washington46, University of Paris-Sud47, University of St Andrews48, Washington University in St. Louis49, Seoul National University50, University of Poitiers51, Université de Montréal52, University of Dundee53, University of Sharjah54, University of Mississippi55, Boston Children's Hospital56, University of California, San Diego57, Federal University of São Paulo58, German Red Cross59, Jagiellonian University60, Chiba University61, American Pharmacists Association62, Sofia Medical University63, University of Nevada, Reno64, Finnish Institute of Occupational Health65, Catholic University of Leuven66, Radboud University Nijmegen67, University of Rostock68, National University of Singapore69, Karolinska Institutet70, University of North Carolina at Chapel Hill71, University of Minnesota72, Catholic University of Cordoba73
TL;DR: Development and implementation of guidelines in allergic rhinitis – an ARIA‐GA2LEN paper.
Abstract: The links between asthma and rhinitis are well characterized. The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines stress the importance of these links and provide guidance for their prevention and treatment. Despite effective treatments being available, too few patients receive appropriate medical care for both diseases. Most patients with rhinitis and asthma consult primary care physicians and therefore these physicians are encouraged to understand and use ARIA guidelines. Patients should also be informed about these guidelines to raise their awareness of optimal care and increase control of the two related diseases. To apply these guidelines, clinicians and patients need to understand how and why the recommendations were made. The goal of the ARIA guidelines is to provide recommendations about the best management options for most patients in most situations. These recommendations should be based on the best available evidence. Making recommendations requires the assessment of the quality of available evidence, deciding on the balance between benefits and downsides, consideration of patients’ values and preferences, and, if applicable, resource implications. Guidelines must be updated as new management options become available or important new evidence emerges. Transparent reporting of guidelines facilitates understanding and acceptance, but implementation strategies need to be improved.
96 citations
••
TL;DR: Partly automated GMP-generation of CAR T cells from critically small blood samples was feasible with a new stimulation protocol that leads to high functionality and expansion potential, balanced CD4/CD8 ratios and a conversion to a Tcm/Tscm phenotype.
Abstract: Relapsed/refractory B-precursor acute lymphoblastic leukemia (pre-B ALL) remains a major therapeutic challenge. Chimeric antigen receptor (CAR) T cells are promising treatment options. Central memory T cells (Tcm) and stem cell-like memory T cells (Tscm) are known to promote sustained proliferation and persistence after T-cell therapy, constituting essential preconditions for treatment efficacy. Therefore, we set up a protocol for anti-CD19 CAR T-cell generation aiming at high Tcm/Tscm numbers. 100 ml peripheral blood from pediatric pre-B ALL patients was processed including CD4+/CD8+-separation, T-cell activation with modified anti-CD3/-CD28 reagents and transduction with a 4-1BB-based second generation CAR lentiviral vector. The process was performed on a closed, automated device requiring additional manual/open steps under clean room conditions. The clinical situation of these critically ill and refractory patients with leukemia leads to inconsistent cellular compositions at start of the procedure including high blast counts and low T-cell numbers with exhausted phenotype. Nevertheless, a robust T-cell product was achieved (mean CD4+ = 50%, CD8+ = 39%, transduction = 27%, Tcm = 50%, Tscm = 46%). Strong proliferative potential (up to > 100-fold), specific cytotoxicity and low expression of co-inhibitory molecules were documented. CAR T cells significantly released TH1 cytokines IFN-γ, TNF-α and IL-2 upon target-recognition. In conclusion, partly automated GMP-generation of CAR T cells from critically small blood samples was feasible with a new stimulation protocol that leads to high functionality and expansion potential, balanced CD4/CD8 ratios and a conversion to a Tcm/Tscm phenotype.
96 citations
Authors
Showing all 658 results
Name | H-index | Papers | Citations |
---|---|---|---|
Johannes Oldenburg | 72 | 583 | 18790 |
Bodo Niggemann | 71 | 279 | 19475 |
Norbert Weissmann | 71 | 384 | 21187 |
Hubert Schrezenmeier | 69 | 360 | 16215 |
Triantafyllos Chavakis | 65 | 242 | 13247 |
Klaus Schwarz | 58 | 209 | 13407 |
Willy A. Flegel | 50 | 233 | 6742 |
Rainer M. Bohle | 49 | 235 | 6923 |
Torsten Tonn | 48 | 151 | 11328 |
Daniel Ricklin | 46 | 144 | 10713 |
Erhard Seifried | 44 | 254 | 7967 |
Pamela S. Becker | 42 | 257 | 6256 |
Karen Bieback | 41 | 135 | 10010 |
Halvard Bonig | 41 | 216 | 4828 |
Julia Kzhyshkowska | 40 | 126 | 5963 |