Gettysburg College

About: Gettysburg College is a education organization based out in Gettysburg, Pennsylvania, United States. It is known for research contribution in the topics: Population & Politics. The organization has 1223 authors who have published 2348 publications receiving 52162 citations. The organization is also known as: Pennsylvania College.

Racial Metaphors: Interpreting Sex and AIDS in Africa

Abstract: Western preconceptions regarding African sexuality distorted early research on the social context of AIDS in Africa and limited the scope of preventive policies. Key works cited repeatedly in the social science and policy literature constructed a hypersexualized pan-African culture as the main reason for the high prevalence of HIV in sub-Saharan Africa. Africans were portrayed as the social 'Other' in works marked by sweeping generalizations and innuendo, rather than useful comparative data on sexual behaviour. Although biomedical studies demonstrate the role of numerous factors that influence HIV transmission among poor people, a narrowly behavioural explanation dominated the AIDS-in-Africa discourse for over a decade and still circumscribes preventive strategies in Africa and elsewhere.

Targeting antioxidant pathways with ferrocenylated N-heterocyclic carbene supported gold(i) complexes in A549 lung cancer cells

Abstract: Ferrocene containing N-heterocyclic carbene (NHC) ligated gold(I) complexes of the type [Au(NHC)2]+ were prepared and found to be capable of regulating the formation of reactive oxygen species (ROS) via multiple mechanisms. Single crystal X-ray analysis of bis(1-(ferrocenylmethyl)-3-mesitylimidazol-2-ylidene)-gold(I) chloride (5) and bis(1,3-di(ferrocenylmethyl)imidazol-2-ylidene)-gold(I) chloride (6) revealed a quasi-linear geometry around the gold(I) centers (i.e., the C–Au–C bond angle were measured to be ∼177° and all the Au–Ccarbene bonds distances were in the range of 2.00 (7)–2.03 (1) A). A series of cell studies indicated that cell proliferation inhibition and ROS generation were directly proportional to the amount of ferrocene contained within the [Au(NHC)2]+ complexes (IC50 of 6 < 5 < bis(1-benzyl-3-mesitylimidazol-2-ylidene)-gold(I) chloride (4)). Complexes 4–6 were also confirmed to inhibit thioredoxin reductase as inferred from lipoate reduction assays and increased chelatable intracellular zinc concentrations. RNA microarray gene expression assays revealed that 6 induces endoplasmic reticulum stress response pathways as a result of ROS increase.

Electoral Participation, Ideology, and Party Politics in Post-Communist Europe

Abstract: The relationship between voter participation and party fortunes has received much attention in the voting behavior literature. Specifically, a number of studies on the advanced industrial democracies postulate that left-of-center parties benefit from higher turnout. This article extends that argument to a quite different context: the economically and politically volatile post-communist world. Using aggregate data from 15 post-communist countries between 1990 and 1999, we test the turnout-party vote linkage. We find that, indeed, increased turnout benefits left parties, particularly the successor communist parties, while adversely affecting conservative and nationalist parties.

The Price of Leadership: Campaign Money and the Polarization of Congressional Parties

Abstract: We argue that the leadership selection system, which now gives significant weight to fundraising, helps explain the continuing polarization of the congressional parties. Focusing first on elected party leadership posts, we demonstrate that members will select ideologically extreme leaders over “ideological middlemen” when extremists redistribute more money than their more centrist opponents. We then show that redistributing campaign money also helps ideologues win posts in the extended party leadership, though appointment to such posts by the top leaders (rather than by the caucus) makes the role of money and ideology more complex. Specifically, we demonstrate that top leaders, who are now ideologues themselves, reward the contributions of ideologically like-minded members more heavily than those of ideologically dissimilar members. This produces a more polarized leadership in Congress.