Hospital for Sick Children

About: Hospital for Sick Children is a healthcare organization based out in Toronto, Ontario, Canada. It is known for research contribution in the topics: Population & Medicine. The organization has 4097 authors who have published 3746 publications receiving 129066 citations. The organization is also known as: Sick Kids Hospital & SickKids.

Adolescent dating aggression in Canada and Italy: A cross-national comparison

Abstract: This study compared rates of dating aggression among 16-year-old adolescents in Canada and Italy, as well as differential associations with dyadic risk factors. 664 Canadians (297 boys, 367 girls) and 578 Italians (315 boys, 263 girls) indicated the frequency of physical aggression towards a romantic partner. They also rated the level of conflict and power imbalance in their romantic relationship. The results revealed comparable rates of physical dating aggression in the two countries for both boys and girls. Dyadic risk factors were also significant, with levels of conflict associated with dating aggression in both countries, and power imbalance uniquely linked in Italy. Overall, the results point to dating aggression as a global problem among youth.

Children of immigrants. The adjustment of Ugandan Asian primary-school children in Canada.

Abstract: The study examines the psychological and academic adjustment to Canada of 51 Ugandan Asian primary school-aged children and their families. Twenty-six percent of all the children showed significant...

A critical appraisal of radiographic scoring systems for assessment of juvenile idiopathic arthritis

Abstract: Assessing structural damage to joints over time is essential for evaluating the effectiveness of therapeutic interventions for patients with inflammatory arthritis. Although radiography is able to quantify joint damage, the changes found with conventional radiography early in the disease course are nonspecific, and late radiographic changes are often irreversible. Although many clinical trials on drug development for children still use radiographic scales as endpoints for the study, more specific therapies have been developed for juvenile idiopathic arthritis (JIA) that would enable imaging to “fine-tune” patients to placement into specific treatment algorithms. As a result, new imaging scales to identify early abnormalities are clearly needed. Many pediatric rheumatology centers around the world persistently apply adult-designed radiographic scoring systems to evaluate the progression of JIA. Few pediatric-targeted radiographic scales are available for assessment of progression of JIA in growing joints, and the clinimetric and psychometric properties of such scales have been poorly investigated. We present a critique to the evaluative, discriminative, and predictive roles of the van der Heijde modification of Sharp’s radiographic method, a scale originally designed to assess damage to joints of adults with rheumatoid arthritis, when it is applied to a pediatric population. We discuss the advantages and drawbacks of this radiographic scoring system for assessing growing joints and the ability of MRI to overcome inadequacies of conventional radiography.

Perivascular epithelioid cell tumor of the orbit: a case report and review of the literature.

Abstract: We present a unique case of a perivascular epithelioid cell tumor (PEComa) in the orbit of a 9-year-old female patient. The entity of PEComas has been described only recently. Characteristic histologic features and an immunohistochemical profile of negativity for epithelial markers and positivity for melanogenesis-related markers define the tumors. In children and young adults, this tumor has a predilection for the falciform ligament and ligamentum teres of the liver. It is associated with, but not exclusive to, tuberous sclerosis. To the best of our knowledge, this is the first reported case of a PEComa of the orbit in a child or adult. The main differential diagnoses for this melanin pigment-producing lesion include melanoma and pigmented paraganglioma. The histologic features, immunohistochemical profile, ultrastructural studies, and molecular studies led us to favor a diagnosis of PEComa. The prognosis of this entity is undetermined due largely to the small number of reported cases.