Kangwon National University

About: Kangwon National University is a education organization based out in Chuncheon, South Korea. It is known for research contribution in the topics: Population & Catalysis. The organization has 9836 authors who have published 20002 publications receiving 393562 citations. The organization is also known as: KNU.

Effects of sophoraflavanone G, a prenylated flavonoid from Sophora flavescens, on cyclooxygenase-2 and in vivo inflammatory response.

Abstract: Previously, several prenylated flavonoids having a C-8 lavandulyl moiety were found to inhibit cyclooxygenase-1 (COX-1) as well as 5-lipoxygenase (5-LOX), and sophoraflavanone G was the most potent inhibitor against these eicosanoid generating enzymes among 19 prenylated flavonoids tested. In this investigation, effects of sophoraflavanone G on COX-2 induction from RAW 264.7 cells and in vivo inflammatory response were studied. Sophoraflavanone G inhibited prostaglandin E2 (PGE2) production from lipopolysaccharide (LPS)-treated RAW cells by COX-2 down-regulation at 1-50 uM. Other prenylated flavonoids including kuraridin and sanggenon D also down-regulated COX-2 induction at 10-25 uM, while kurarinone and echinoisoflavanone did not. In addition, sophoraflavanone G showed in vivo anti-inflammatory activity against mouse croton oil-induced ear edema and rat carrageenan paw edema via oral (2-250 mg/kg) or topical administration (10-250 microg/ear). Although the potencies of inhibition were far less than that of a reference drug, prednisolone, this compound showed higher anti-inflammatory activity when applied topically, suggesting a potential use for several eicosanoid-related skin inflammation such as atopic dermatitis.

A Balun-BPF Using a Dual Mode Ring Resonator

Abstract: In this letter, a Balun-bandpass filter (BPF) is proposed by using a dual-mode ring resonator. The Balun-BPF is not a simply combined or integrated component of a BPF and a Balun but a single BPF with the balun function. We obtained the proper balanced outputs and two-pole BPF characteristic by symmetrically placing the output ports at lambda/2 distance from each other on the dual-mode ring resonator. The fabricated Balun-BPF has a bandwidth of 40 MHz and an insertion loss of 2.4 dB at a center frequency of 2.45 GHz. The differences between the two outputs are 180-184deg in phase and within 1dB in magnitude. The measured frequency responses agree well with simulated ones.

Regulation of caspases by nitric oxide.

Abstract: Nitric oxide can prevent or induce apoptosis depending on its concentration, cell type, and the oxidative milieu Nitric oxide inhibits apoptosis and inflammation by S-nitrosylation of the active site cysteine of caspases, the central effector molecules of cell death as well as maturation of IL-1beta and IL-18 The ability of nitric oxide to S-nitrosylate caspases depends on multiple factors including the presence of free iron and intracellular redox potential There are no known direct effects of nitric oxide on promoting caspase activation or activity However, nitric oxide has been shown to promote apoptotic pathways in numerous cell types through the indirect activation of caspases In this article we review the relationship of nitric oxide and caspase activity, modulation of this effect by iron, and clinical implications for the use of nitric oxide in regulating inflammation and apoptosis

Synthesis of Pyrazines from Rhodium-Catalyzed Reaction of 2H-Azirines with N-Sulfonyl 1,2,3-Triazoles

Abstract: An efficient synthetic route to a wide range of trisubstituted pyrazines is developed from Rh-catalyzed reaction of 2H-azirines with N-sulfonyl-1,2,3-triazoles through the elimination of nitrogen molecule and arylsulfinic acid. The present reaction proceeds through formation of in situ generated dihydropyrazines.