Institution
Kangwon National University
Education•Chuncheon, South Korea•
About: Kangwon National University is a education organization based out in Chuncheon, South Korea. It is known for research contribution in the topics: Population & Catalysis. The organization has 9836 authors who have published 20002 publications receiving 393562 citations. The organization is also known as: KNU.
Topics: Population, Catalysis, Large Hadron Collider, Gene, Signal transduction
Papers published on a yearly basis
Papers
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TL;DR: The data suggest that surfactin may have anti‐cancer properties as a result of its ability to downregulate the cell cycle and suppress its survival.
156 citations
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TL;DR: In this paper, the authors evaluated the effectiveness of eggshell and calcined eggshell on lead (Pb) immobilization in a shooting range soil, and found that the 5% additions of eggs and calcine-eggshell significantly decreased the TCLP-Pb concentration by 68.8% due mainly to increasing soil pH.
156 citations
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TL;DR: Although gene deletion of TRPC3 or TRPC6 alone did not protect against hypertrophy or dysfunction from pressure overload, combined deletion was protective, supporting the value of dual inhibition and further development of this pharmaceutical class may yield a useful therapeutic agent for heart disease management.
Abstract: Chronic neurohormonal and mechanical stresses are central features of heart disease. Increasing evidence supports a role for the transient receptor potential canonical channels TRPC3 and TRPC6 in this pathophysiology. Channel expression for both is normally very low but is increased by cardiac disease, and genetic gain- or loss-of-function studies support contributions to hypertrophy and dysfunction. Selective small-molecule inhibitors remain scarce, and none target both channels, which may be useful given the high homology among them and evidence of redundant signaling. Here we tested selective TRPC3/6 antagonists (GSK2332255B and GSK2833503A; IC50, 3–21 nM against TRPC3 and TRPC6) and found dose-dependent blockade of cell hypertrophy signaling triggered by angiotensin II or endothelin-1 in HEK293T cells as well as in neonatal and adult cardiac myocytes. In vivo efficacy in mice and rats was greatly limited by rapid metabolism and high protein binding, although antifibrotic effects with pressure overload were observed. Intriguingly, although gene deletion of TRPC3 or TRPC6 alone did not protect against hypertrophy or dysfunction from pressure overload, combined deletion was protective, supporting the value of dual inhibition. Further development of this pharmaceutical class may yield a useful therapeutic agent for heart disease management.
155 citations
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TL;DR: In this article, the particle surface of Li[Ni 1/3 Co1/3 Mn 1/ 3 ]O 2 was modified by AlF 3 as a new coating material to improve the electrochemical properties in the high cutoff voltage of 4.5 V.
155 citations
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TL;DR: The current results suggest that curcumin is a promising agent for the prevention and treatment of both NO and microglial cell-mediated neurodegenerative disorders.
155 citations
Authors
Showing all 9904 results
Name | H-index | Papers | Citations |
---|---|---|---|
Marco Zanetti | 145 | 1439 | 104610 |
Teruki Kamon | 142 | 2034 | 115633 |
G. Della Ricca | 133 | 1598 | 92678 |
Anna Kropivnitskaya | 128 | 1221 | 80563 |
Filip Thyssen | 125 | 827 | 69781 |
Giacomo Fedi | 122 | 814 | 66889 |
Shi Xue Dou | 122 | 2028 | 74031 |
Anna Zanetti | 120 | 1488 | 71375 |
Aldo Penzo | 120 | 1223 | 80085 |
Stefano Belforte | 118 | 1070 | 69606 |
Matteo Marone | 115 | 540 | 53662 |
Vieri Candelise | 113 | 975 | 61581 |
Soon-Kwon Nam | 111 | 537 | 54979 |
Andrea Schizzi | 107 | 475 | 47634 |
Michael R. Wasielewski | 107 | 766 | 49082 |