Institution
Kangwon National University
Education•Chuncheon, South Korea•
About: Kangwon National University is a education organization based out in Chuncheon, South Korea. It is known for research contribution in the topics: Population & Catalysis. The organization has 9836 authors who have published 20002 publications receiving 393562 citations. The organization is also known as: KNU.
Topics: Population, Catalysis, Large Hadron Collider, Gene, Signal transduction
Papers published on a yearly basis
Papers
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TL;DR: In this article, spatial and temporal patterns of changes in extreme events of temperature and precipitation at 143 weather stations in ten Asia-Pacific Network (APN) countries and their associations with changes in climate means are examined for the 1955-2007 period.
Abstract: In this study, spatial and temporal patterns of changes in extreme events of temperature and precipitation at 143 weather stations in ten Asia-Pacific Network (APN) countries and their associations with changes in climate means are examined for the 1955–2007 period. Averaged over the APN region, annual frequency of cool nights (days) has decreased by 6.4 days/decade (3.3 days/decade), whereas the frequency of warm nights (days) has increased by 5.4 days/decade (3.9 days/decade). The change rates in the annual frequency of warm nights (days) over the last 20 years (1988–2007) have exceeded those over the full 1955–2007 period by a factor of 1.8 (3.4). Seasonally, the frequencies of summer warm nights and days are changing more rapidly per unit change in mean temperatures than the corresponding frequencies for cool nights and days. However, normalization of the extreme and mean series shows that the rate of changes in extreme temperature events are generally less than that of mean temperatures, except for winter cold nights which are changing as rapidly as the winter mean minimum temperature. These results indicate that there have been seasonally and diurnally asymmetric changes in extreme temperature events relative to recent increases in temperature means in the APN region.
There are no systematic, regional trends over the study period in total precipitation, or in the frequency and duration of extreme precipitation events. Statistically significant trends in extreme precipitation events are observed at fewer than 30% of all weather stations, with no spatially coherent pattern of change, whereas statistically significant changes in extreme temperature events have occurred at more than 70% of all weather stations, forming strongly coherent spatial patterns. Copyright © 2009 Royal Meteorological Society
300 citations
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TL;DR: In this paper, a search for events with jets and missing transverse energy is performed in a data sample of pp collisions collected at 7 TeV by the CMS experiment at the LHC.
Abstract: A search for events with jets and missing transverse energy is performed in a data sample of pp collisions collected at sqrt(s) = 7 TeV by the CMS experiment at the LHC. The analyzed data sample corresponds to an integrated luminosity of 1.14 inverse femtobarns. In this search, a kinematic variable, alphaT, is used as the main discriminator between events with genuine and misreconstructed missing transverse energy. No excess of events over the standard model expectation is found. Exclusion limits in the parameter space of the constrained minimal supersymmetric extension of the standard model are set. In this model, squark masses below 1.1 TeV are excluded at 95% CL. Gluino masses below 1.1 TeV are also ruled out at 95% CL for values of the universal scalar mass parameter below 500 GeV.
300 citations
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TL;DR: The results highlight the utility of exome-sequencing technology in finding causal mutations in nuclear families with dominantly inherited traits otherwise intractable by linkage analysis.
Abstract: Whole-exome sequencing was performed in a family affected by dominantly inherited inflammatory disease characterized by recurrent blistering skin lesions, bronchiolitis, arthralgia, ocular inflammation, enterocolitis, absence of autoantibodies, and mild immunodeficiency. Exome data from three samples, including the affected father and daughter and unaffected mother, were filtered for the exclusion of reported variants, along with benign variants, as determined by PolyPhen-2. A total of eight transcripts were identified as possible candidate genes. We confirmed a variant, c.2120C>A (p.Ser707Tyr), within PLCG2 as the only de novo variant that was present in two affected family members and not present in four unaffected members. PLCG2 encodes phospholipase Cγ2 (PLCγ2), an enzyme with a critical regulatory role in various immune and inflammatory pathways. The p.Ser707Tyr substitution is located in an autoinhibitory SH2 domain that is crucial for PLCγ2 activation. Overexpression of the altered p.Ser707Tyr protein and ex vivo experiments using affected individuals’ leukocytes showed clearly enhanced PLCγ2 activity, suggesting increased intracellular signaling in the PLCγ2-mediated pathway. Recently, our laboratory identified in individuals with cold-induced urticaria and immune dysregulation PLCG2 exon-skipping mutations resulting in protein products with constitutive phospholipase activity but with reduced intracellular signaling at physiological temperatures. In contrast, the p.Ser707Tyr substitution in PLCγ2 causes a distinct inflammatory phenotype that is not provoked by cold temperatures and that has different end-organ involvement and increased intracellular signaling at physiological temperatures. Our results highlight the utility of exome-sequencing technology in finding causal mutations in nuclear families with dominantly inherited traits otherwise intractable by linkage analysis.
300 citations
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TL;DR: In this article, the performance of anaerobic digesters using a mixture of apple waste (AW) and swine manure (SM) was evaluated using both batch and continuous digesters.
298 citations
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Harvard University1, University of Groningen2, Laval University3, University of Leicester4, University of Nottingham5, National Institutes of Health6, University of North Carolina at Chapel Hill7, St George's, University of London8, Johns Hopkins University9, Anschutz Medical Campus10, University of Colorado Denver11, University of Washington12, Group Health Cooperative13, Utrecht University14, GlaxoSmithKline15, University of Nebraska Medical Center16, AstraZeneca17, University of Manchester18, University of British Columbia19, Boston University20, Kangwon National University21, University of Ulsan22, Erasmus University Rotterdam23, Lovelace Respiratory Research Institute24, University of Virginia25, Columbia University26, University of Bergen27, Ghent University28, Wake Forest University29, University of California, San Francisco30, University College London31, Seoul National University32, University of Edinburgh33, Glenfield Hospital34
TL;DR: In the combined meta-analysis, 22 loci associated at genome-wide significance are identified, including 13 new associations with COPD, including 12 associated with lung function in general population samples, while 4 are new.
Abstract: Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. We performed a genetic association study in 15,256 cases and 47,936 controls, with replication of select top results (P < 5 × 10(-6)) in 9,498 cases and 9,748 controls. In the combined meta-analysis, we identified 22 loci associated at genome-wide significance, including 13 new associations with COPD. Nine of these 13 loci have been associated with lung function in general population samples, while 4 (EEFSEC, DSP, MTCL1, and SFTPD) are new. We noted two loci shared with pulmonary fibrosis (FAM13A and DSP) but that had opposite risk alleles for COPD. None of our loci overlapped with genome-wide associations for asthma, although one locus has been implicated in joint susceptibility to asthma and obesity. We also identified genetic correlation between COPD and asthma. Our findings highlight new loci associated with COPD, demonstrate the importance of specific loci associated with lung function to COPD, and identify potential regions of genetic overlap between COPD and other respiratory diseases.
292 citations
Authors
Showing all 9904 results
Name | H-index | Papers | Citations |
---|---|---|---|
Marco Zanetti | 145 | 1439 | 104610 |
Teruki Kamon | 142 | 2034 | 115633 |
G. Della Ricca | 133 | 1598 | 92678 |
Anna Kropivnitskaya | 128 | 1221 | 80563 |
Filip Thyssen | 125 | 827 | 69781 |
Giacomo Fedi | 122 | 814 | 66889 |
Shi Xue Dou | 122 | 2028 | 74031 |
Anna Zanetti | 120 | 1488 | 71375 |
Aldo Penzo | 120 | 1223 | 80085 |
Stefano Belforte | 118 | 1070 | 69606 |
Matteo Marone | 115 | 540 | 53662 |
Vieri Candelise | 113 | 975 | 61581 |
Soon-Kwon Nam | 111 | 537 | 54979 |
Andrea Schizzi | 107 | 475 | 47634 |
Michael R. Wasielewski | 107 | 766 | 49082 |