Institution
Kazan Federal University
Education•Kazan’, Russia•
About: Kazan Federal University is a education organization based out in Kazan’, Russia. It is known for research contribution in the topics: Population & Chemistry. The organization has 9868 authors who have published 14390 publications receiving 135726 citations. The organization is also known as: Kazan (Volga region) Federal University & Kazan State University.
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the role of the high-mobility-group AT-hook protein 2 (HMGA2) during lung development was decrypted by analyzing the lung of Hmga2-deficient mice.
Abstract: The high-mobility-group (HMG) proteins are the most abundant non-histone chromatin-associated proteins. HMG proteins are present at high levels in various undifferentiated tissues during embryonic development and their levels are strongly reduced in the corresponding adult tissues, where they have been implicated in maintaining and activating stem/progenitor cells. Here we deciphered the role of the high-mobility-group AT-hook protein 2 (HMGA2) during lung development by analyzing the lung of Hmga2-deficient mice (Hmga2
−/−
). We found that Hmga2 is expressed in the mouse embryonic lung at the distal airways. Analysis of Hmga2
−/−
mice showed that Hmga2 is required for proper cell proliferation and distal epithelium differentiation during embryonic lung development. Hmga2 knockout led to enhanced canonical WNT signaling due to an increased expression of secreted WNT glycoproteins Wnt2b, Wnt7b and Wnt11 as well as a reduction of the WNT signaling antagonizing proteins GATA-binding protein 6 and frizzled homolog 2. Analysis of siRNA-mediated loss-of-function experiments in embryonic lung explant culture confirmed the role of Hmga2 as a key regulator of distal lung epithelium differentiation and supported the causal involvement of enhanced canonical WNT signaling in mediating the effect of Hmga2-loss-of-fuction. Finally, we found that HMGA2 directly regulates Gata6 and thereby modulates Fzd2 expression. Our results support that Hmga2 regulates canonical WNT signaling at different points of the pathway. Increased expression of the secreted WNT glycoproteins might explain a paracrine effect by which Hmga2-knockout enhanced cell proliferation in the mesenchyme of the developing lung. In addition, HMGA2-mediated direct regulation of Gata6 is crucial for fine-tuning the activity of WNT signaling in the airway epithelium. Our results are the starting point for future studies investigating the relevance of Hmga2-mediated regulation of WNT signaling in the adult lung within the context of proper balance between differentiation and self-renewal of lung stem/progenitor cells during lung regeneration in both homeostatic turnover and repair after injury.
52 citations
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TL;DR: New acetylcholinesterase (AChE) biosensor based on unsubstituted pillar [5]arene (P[5]A) as electron mediator was developed and successfully used for highly sensitive detection of organophosphate and carbamate pesticides.
52 citations
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TL;DR: A series of 12 asphaltene samples extracted from heavy oils and the oxidized bitumen of different origin has been studied with high-frequency W-band (94 GHz) pulsed electron paramagnetic resonance (EPR) spectroscopy.
Abstract: A series of 12 asphaltene samples extracted from heavy oils and the oxidized bitumen of different origin has been studied with high-frequency W-band (94 GHz) pulsed electron paramagnetic resonance (EPR) spectroscopy. Transverse (T2e) and longitudinal (T1e) relaxation times of the free radical (FR) and the vanadyl porphyrin (VO2+) were measured for each sample. A significant contribution of the spectral diffusion to T2e has been revealed and ascribed to the dipole–dipole interaction between the FR and VO2+. This indicates that the distance between the FR and VO2+ does not exceed a few nanometers, which means, in turn, that VO2+ can participate in construction of the asphaltene aggregates via the intermolecular interactions.
52 citations
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TL;DR: An electrochemical aptasensor for ochratoxin A (OTA) detection has been developed on the base of a gold electrode covered with electropolymerized neutral red and silver nanoparticles obtained by chemical reduction with macrocyclic ligands bearing catechol fragments as mentioned in this paper.
Abstract: An electrochemical aptasensor for ochratoxin A (OTA) detection has been developed on the base of a gold electrode covered with electropolymerized neutral red and silver nanoparticles obtained by chemical reduction with macrocyclic ligands bearing catechol fragments. Thiolated aptamers against OTA were covalently attached to silver nanoparticles via AgS bonding. The interaction with OTA induced the conformational switch of the aptamer, which caused increase of the charge transfer resistance measured by EIS in the presence of ferricyanide ions. The LOD achieved (0.05 nM) was comparable to other electrochemical aptasensors employing sophisticated assembling technique and enzyme amplification of the signal. The aptasensor was validated in spiked beer samples. The recovery of the OTA determination was found to be 66.3 14.1 % for light beer and 64.3 1.8 % for dark beer.
52 citations
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TL;DR: Different aspects of applications of electron paramagnetic resonance (EPR) based techniques including high frequency (HF) electron spin echo (ESE), electron-nuclear double resonance (ENDOR) and optically detected magnetic resonance (ODMR) approaches to study diamond nanostructures are examined in this article.
Abstract: Different aspects of applications of electron paramagnetic resonance (EPR) based techniques including high frequency (HF) electron spin echo (ESE), electron-nuclear double resonance (ENDOR) and optically detected magnetic resonance (ODMR) approaches to study diamond nanostructures are examined.
52 citations
Authors
Showing all 10096 results
Name | H-index | Papers | Citations |
---|---|---|---|
Richard G. Pestell | 130 | 479 | 54210 |
Alexander Spiridonov | 126 | 1198 | 77296 |
V. Stolyarov | 119 | 238 | 79004 |
Sergei D. Odintsov | 112 | 609 | 62524 |
Hans-Uwe Simon | 96 | 461 | 51698 |
Yuri Lvov | 89 | 342 | 27397 |
Alexei A. Starobinsky | 88 | 340 | 42331 |
Yakov Kuzyakov | 87 | 667 | 37050 |
V. E. Semenov | 74 | 372 | 22577 |
John W. Weisel | 73 | 323 | 17866 |
Klaus T. Preissner | 72 | 333 | 21289 |
Alexander Tropsha | 71 | 288 | 22898 |
Roland Winter | 68 | 468 | 15193 |
Christoph Schick | 68 | 443 | 16664 |
Marat Gilfanov | 62 | 350 | 14987 |